6DNE
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![BU of 6dne by Molmil](/molmil-images/mine/6dne) | Crystal structure of human Bromodomain-containing protein 4 (BRD4) bromodomain with MS660 | 分子名称: | Bromodomain-containing protein 4, N,N'-[ethane-1,2-diylbis(oxyethane-2,1-diyl)]bis{2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetamide} | 著者 | Ren, C, Zhou, M.M. | 登録日 | 2018-06-06 | 公開日 | 2018-07-18 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.958 Å) | 主引用文献 | Spatially constrained tandem bromodomain inhibition bolsters sustained repression of BRD4 transcriptional activity for TNBC cell growth. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6DJC
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![BU of 6djc by Molmil](/molmil-images/mine/6djc) | Crystal structure of human Bromodomain-containing protein 4 (BRD4) bromodomain with MS645 | 分子名称: | 1,2-ETHANEDIOL, Bromodomain-containing protein 4, N,N'-(decane-1,10-diyl)bis{2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetamide} | 著者 | Ren, C, Zhou, M.M. | 登録日 | 2018-05-25 | 公開日 | 2018-07-25 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | 主引用文献 | Spatially constrained tandem bromodomain inhibition bolsters sustained repression of BRD4 transcriptional activity for TNBC cell growth. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6DUV
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![BU of 6duv by Molmil](/molmil-images/mine/6duv) | Crystal structure of the second bromodomain of human BRD4 in complex with MS417 inhibitor | 分子名称: | 1,2-ETHANEDIOL, Bromodomain-containing protein 4, methyl [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate | 著者 | Babault, N, Zhou, M.M. | 登録日 | 2018-06-22 | 公開日 | 2019-06-26 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Role of Bound Water Molecules in Differential Recognition of Di-Acetylated Histone Peptides by the BRD4 Bromodomains To be published
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4X3K
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![BU of 4x3k by Molmil](/molmil-images/mine/4x3k) | |
4X3U
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![BU of 4x3u by Molmil](/molmil-images/mine/4x3u) | Crystal structure of chromobox homolog 7 (CBX7) chromodomain with Suramin | 分子名称: | 8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFON IC ACID, Chromobox protein homolog 7 | 著者 | Ren, C, Zhou, M.M. | 登録日 | 2014-12-01 | 公開日 | 2015-03-04 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Small-Molecule Modulators of Methyl-Lysine Binding for the CBX7 Chromodomain. Chem.Biol., 22, 2015
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4X3S
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![BU of 4x3s by Molmil](/molmil-images/mine/4x3s) | Crystal structure of chromobox homology 7 (CBX7) with SETDB1-1170me3 Peptide | 分子名称: | CITRIC ACID, Chromobox protein homolog 7, FE (III) ION, ... | 著者 | Ren, C, Plotnikov, A.N, Zhou, M.M. | 登録日 | 2014-12-01 | 公開日 | 2015-03-04 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Small-Molecule Modulators of Methyl-Lysine Binding for the CBX7 Chromodomain. Chem.Biol., 22, 2015
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4X3T
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![BU of 4x3t by Molmil](/molmil-images/mine/4x3t) | Crystal structure of chromobox homolog 7 (CBX7) chromodomain with MS37452 | 分子名称: | 1,2-ETHANEDIOL, 1-[4-(2,3-dimethoxybenzoyl)piperazin-1-yl]-2-(3-methylphenoxy)ethanone, Chromobox protein homolog 7, ... | 著者 | Ren, C, Jakoncic, J, Zhou, M.M. | 登録日 | 2014-12-01 | 公開日 | 2015-03-04 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | 主引用文献 | Small-Molecule Modulators of Methyl-Lysine Binding for the CBX7 Chromodomain. Chem.Biol., 22, 2015
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3LJW
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![BU of 3ljw by Molmil](/molmil-images/mine/3ljw) | Crystal Structure of the Second Bromodomain of Human Polybromo | 分子名称: | ACETATE ION, Protein polybromo-1, SODIUM ION | 著者 | Charlop-Powers, Z, Zhou, M.M, Zeng, L, Zhang, Q. | 登録日 | 2010-01-26 | 公開日 | 2010-05-19 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.501 Å) | 主引用文献 | Structural insights into selective histone H3 recognition by the human Polybromo bromodomain 2. Cell Res., 20, 2010
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3KMT
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![BU of 3kmt by Molmil](/molmil-images/mine/3kmt) | |
3KMJ
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![BU of 3kmj by Molmil](/molmil-images/mine/3kmj) | |
3KMA
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![BU of 3kma by Molmil](/molmil-images/mine/3kma) | |
1WUG
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![BU of 1wug by Molmil](/molmil-images/mine/1wug) | complex structure of PCAF bromodomain with small chemical ligand NP1 | 分子名称: | Histone acetyltransferase PCAF, N-(3-AMINOPROPYL)-4-METHYL-2-NITROBENZENAMINE | 著者 | Zeng, L, Li, J, Muller, M, Yan, S, Mujtaba, S, Pan, C, Wang, Z, Zhou, M.M. | 登録日 | 2004-12-07 | 公開日 | 2005-08-16 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Selective small molecules blocking HIV-1 Tat and coactivator PCAF association J.Am.Chem.Soc., 127, 2005
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1WUM
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![BU of 1wum by Molmil](/molmil-images/mine/1wum) | Complex structure of PCAF bromodomain with small chemical ligand NP2 | 分子名称: | Histone acetyltransferase PCAF, N-(3-AMINOPROPYL)-2-NITROBENZENAMINE | 著者 | Zeng, L, Li, J, Muller, M, Yan, S, Mujtaba, S, Pan, C, Wang, Z, Zhou, M.M. | 登録日 | 2004-12-08 | 公開日 | 2005-08-16 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Selective small molecules blocking HIV-1 Tat and coactivator PCAF association J.Am.Chem.Soc., 127, 2005
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1SZV
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![BU of 1szv by Molmil](/molmil-images/mine/1szv) | Structure of the Adaptor Protein p14 reveals a Profilin-like Fold with Novel Function | 分子名称: | Late endosomal/lysosomal Mp1 interacting protein | 著者 | Qian, C, Zhang, Q, Wang, X, Zeng, L, Farooq, A, Zhou, M.M. | 登録日 | 2004-04-06 | 公開日 | 2005-03-15 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure of the Adaptor Protein p14 Reveals a Profilin-like Fold with Distinct Function J.Mol.Biol., 347, 2005
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2RNW
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![BU of 2rnw by Molmil](/molmil-images/mine/2rnw) | The Structural Basis for Site-Specific Lysine-Acetylated Histone Recognition by the Bromodomains of the Human Transcriptional Co-Activators PCAf and CBP | 分子名称: | Histone H3, Histone acetyltransferase PCAF | 著者 | Zeng, L, Zhang, Q, Gerona-Navarro, G, Zhou, M.M. | 登録日 | 2008-02-03 | 公開日 | 2008-05-06 | 最終更新日 | 2023-11-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural Basis of Site-Specific Histone Recognition by the Bromodomains of Human Coactivators PCAF and CBP/p300 Structure, 16, 2008
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2RNX
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![BU of 2rnx by Molmil](/molmil-images/mine/2rnx) | The Structural Basis for Site-Specific Lysine-Acetylated Histone Recognition by the Bromodomains of the HUman Transcriptional Co-Activators PCAF and CBP | 分子名称: | Histone H3, Histone acetyltransferase PCAF | 著者 | Zeng, L, Zhang, Q, Gerona-Navarro, G, Zhou, M.M. | 登録日 | 2008-02-03 | 公開日 | 2008-05-06 | 最終更新日 | 2023-11-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural Basis of Site-Specific Histone Recognition by the Bromodomains of Human Coactivators PCAF and CBP/p300 Structure, 16, 2008
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2RNY
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![BU of 2rny by Molmil](/molmil-images/mine/2rny) | Complex Structures of CBP Bromodomain with H4 ack20 Peptide | 分子名称: | CREB-binding protein, Histone H4 | 著者 | Zeng, L, Zhang, Q, Gerona-Navarro, G, Zhou, M.M. | 登録日 | 2008-02-03 | 公開日 | 2008-05-06 | 最終更新日 | 2023-11-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural Basis of Site-Specific Histone Recognition by the Bromodomains of Human Coactivators PCAF and CBP/p300 Structure, 16, 2008
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2G46
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2D82
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![BU of 2d82 by Molmil](/molmil-images/mine/2d82) | Target Structure-Based Discovery of Small Molecules that Block Human p53 and CREB Binding Protein (CBP) Association | 分子名称: | 9-ACETYL-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-ONE, CREB-binding protein | 著者 | Sachchidanand, Resnick-Silverman, L, Yan, S, Mujtaba, S, Liu, W.J, Zeng, L, Manfredi, J.J, Zhou, M.M. | 登録日 | 2005-12-01 | 公開日 | 2006-04-04 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Target structure-based discovery of small molecules that block human p53 and CREB binding protein association Chem.Biol., 13, 2006
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5EJW
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![BU of 5ejw by Molmil](/molmil-images/mine/5ejw) | Crystal structure of chromobox homolog 7 (CBX7) chromodomain with MS351 | 分子名称: | (1~{R})-2-[2-azanylidene-3-[(2-methylphenyl)methyl]benzimidazol-1-yl]-1-(3,4-dichlorophenyl)ethanol, Chromobox protein homolog 7 | 著者 | Ren, C, Zhou, M.M. | 登録日 | 2015-11-02 | 公開日 | 2016-03-09 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure-Guided Discovery of Selective Antagonists for the Chromodomain of Polycomb Repressive Protein CBX7. Acs Med.Chem.Lett., 7, 2016
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