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PDB: 809 件
8GJK
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BU of 8gjk by Molmil
Multi-drug efflux pump RE-CmeB bound with ampicillin
分子名称: (2R,4S)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Efflux pump membrane transporter
著者Zhang, Z.
登録日2023-03-16
公開日2023-05-31
最終更新日2023-10-04
実験手法ELECTRON MICROSCOPY (3.16 Å)
主引用文献Cryo-Electron Microscopy Structures of a Campylobacter Multidrug Efflux Pump Reveal a Novel Mechanism of Drug Recognition and Resistance.
Microbiol Spectr, 11, 2023
8GJL
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BU of 8gjl by Molmil
multi-drug efflux pump RE-CmeB bound with Ciprofloxacin
分子名称: 1-CYCLOPROPYL-6-FLUORO-4-OXO-7-PIPERAZIN-1-YL-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID, Efflux pump membrane transporter
著者Zhang, Z.
登録日2023-03-16
公開日2023-05-31
最終更新日2023-10-04
実験手法ELECTRON MICROSCOPY (3.44 Å)
主引用文献Cryo-Electron Microscopy Structures of a Campylobacter Multidrug Efflux Pump Reveal a Novel Mechanism of Drug Recognition and Resistance.
Microbiol Spectr, 11, 2023
8GJJ
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BU of 8gjj by Molmil
Multi-drug efflux pump RE-CmeB Apo form
分子名称: Efflux pump membrane transporter
著者Zhang, Z.
登録日2023-03-15
公開日2023-05-31
最終更新日2023-10-04
実験手法ELECTRON MICROSCOPY (3.08 Å)
主引用文献Cryo-Electron Microscopy Structures of a Campylobacter Multidrug Efflux Pump Reveal a Novel Mechanism of Drug Recognition and Resistance.
Microbiol Spectr, 11, 2023
6LW1
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BU of 6lw1 by Molmil
Cryo-EM structure of TLR7/Cpd-7 (DSR-139970) complex in open form
分子名称: 2-ethoxy-8-(5-fluoranylpyridin-3-yl)-6-methyl-9-[[4-[[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]phenyl]methyl]purine, Toll-like receptor 7
著者Zhang, Z, Ohto, U, Shimizu, T.
登録日2020-02-06
公開日2020-11-11
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Structural analysis reveals TLR7 dynamics underlying antagonism.
Nat Commun, 11, 2020
8GK4
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BU of 8gk4 by Molmil
Multi-drug efflux pump RE-CmeB bound with Chloramphenicol
分子名称: CHLORAMPHENICOL, Efflux pump membrane transporter
著者Zhang, Z.
登録日2023-03-17
公開日2023-05-31
最終更新日2023-10-04
実験手法ELECTRON MICROSCOPY (3.12 Å)
主引用文献Cryo-Electron Microscopy Structures of a Campylobacter Multidrug Efflux Pump Reveal a Novel Mechanism of Drug Recognition and Resistance.
Microbiol Spectr, 11, 2023
8GK0
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BU of 8gk0 by Molmil
Multi-drug efflux pump RE-CmeB bound with Erythromycin
分子名称: ERYTHROMYCIN A, Efflux pump membrane transporter
著者Zhang, Z.
登録日2023-03-16
公開日2023-06-07
最終更新日2023-10-04
実験手法ELECTRON MICROSCOPY (3.44 Å)
主引用文献Cryo-Electron Microscopy Structures of a Campylobacter Multidrug Efflux Pump Reveal a Novel Mechanism of Drug Recognition and Resistance.
Microbiol Spectr, 11, 2023
4GE2
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BU of 4ge2 by Molmil
Crystal structure of human protein tyrosine phosphatase PTPN9 (MEG2) complex with compound 3
分子名称: N-acetyl-4-[difluoro(phosphono)methyl]-L-phenylalanyl-N~5~-(3-iodobenzoyl)-L-ornithinamide, Tyrosine-protein phosphatase non-receptor type 9
著者Zhang, Z.-Y, Liu, S, Zhang, S.
登録日2012-08-01
公開日2012-10-31
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A Highly Selective and Potent PTP-MEG2 Inhibitor with Therapeutic Potential for Type 2 Diabetes.
J.Am.Chem.Soc., 134, 2012
8F4R
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BU of 8f4r by Molmil
Gentamicin bound aminoglycoside efflux pump AcrD
分子名称: (2R,3R,4R,5R)-2-((1S,2S,3R,4S,6R)-4,6-DIAMINO-3-((2R,3R,6S)-3-AMINO-6-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-2-HYDR OXYCYCLOHEXYLOXY)-5-METHYL-4-(METHYLAMINO)-TETRAHYDRO-2H-PYRAN-3,5-DIOL, Efflux pump membrane transporter
著者Zhang, Z.
登録日2022-11-11
公開日2022-12-28
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3.06 Å)
主引用文献Cryo-EM Structures of AcrD Illuminate a Mechanism for Capturing Aminoglycosides from Its Central Cavity.
Mbio, 14, 2023
8F56
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BU of 8f56 by Molmil
Dimer of aminoglycoside efflux pump AcrD treated with gentamicin
分子名称: Efflux pump membrane transporter
著者Zhang, Z.
登録日2022-11-11
公開日2022-12-28
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (2.98 Å)
主引用文献Cryo-EM Structures of AcrD Illuminate a Mechanism for Capturing Aminoglycosides from Its Central Cavity.
Mbio, 14, 2023
8F4N
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BU of 8f4n by Molmil
Dimer of aminoglycoside efflux pump AcrD
分子名称: Efflux pump membrane transporter
著者Zhang, Z.
登録日2022-11-11
公開日2022-12-28
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (2.95 Å)
主引用文献Cryo-EM Structures of AcrD Illuminate a Mechanism for Capturing Aminoglycosides from Its Central Cavity.
Mbio, 14, 2023
4GE5
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BU of 4ge5 by Molmil
Crystal structure of human protein tyrosine phosphatase PTPN9 (MEG2) complex with compound 5
分子名称: N-(4-bromo-3-methylbenzoyl)-4-[difluoro(phosphono)methyl]-L-phenylalanyl-N~5~-(3-iodobenzoyl)-L-ornithinamide, Tyrosine-protein phosphatase non-receptor type 9
著者Zhang, Z.-Y, Liu, S, Zhang, S.
登録日2012-08-01
公開日2012-10-31
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A Highly Selective and Potent PTP-MEG2 Inhibitor with Therapeutic Potential for Type 2 Diabetes.
J.Am.Chem.Soc., 134, 2012
4LK2
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BU of 4lk2 by Molmil
Crystal structure of RNA splicing effector Prp5
分子名称: NICKEL (II) ION, Pre-mRNA-processing ATP-dependent RNA helicase PRP5
著者Zhang, Z.-M, Li, J, Yang, F, Xu, Y, Zhou, J.
登録日2013-07-05
公開日2013-12-11
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.12 Å)
主引用文献Crystal structure of Prp5p reveals interdomain interactions that impact spliceosome assembly.
Cell Rep, 5, 2013
8HGW
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BU of 8hgw by Molmil
Crystal structure of MehpH in complex with MBP
分子名称: 1-BUTANOL, Monoalkyl phthalate hydrolase, PHTHALIC ACID
著者Zhang, Z.M, Wang, Y.J, Chen, Y.B.
登録日2022-11-15
公開日2023-03-15
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.80001163 Å)
主引用文献Molecular insights into the catalytic mechanism of plasticizer degradation by a monoalkyl phthalate hydrolase.
Commun Chem, 6, 2023
8HGV
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BU of 8hgv by Molmil
Crystal structure of monoalkyl phthalate hydrolase MehpH
分子名称: Monoethylhexylphthalate hydrolase
著者Zhang, Z.M, Wang, Y.J, Chen, Y.B.
登録日2022-11-15
公開日2023-03-15
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.30006242 Å)
主引用文献Molecular insights into the catalytic mechanism of plasticizer degradation by a monoalkyl phthalate hydrolase.
Commun Chem, 6, 2023
5C6D
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BU of 5c6d by Molmil
Crystal structure of USP7 in complex with UHRF1
分子名称: E3 ubiquitin-protein ligase UHRF1, Ubiquitin carboxyl-terminal hydrolase 7
著者Zhang, Z.-M, Song, J.
登録日2015-06-22
公開日2015-09-09
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.292 Å)
主引用文献An Allosteric Interaction Links USP7 to Deubiquitination and Chromatin Targeting of UHRF1.
Cell Rep, 12, 2015
4LJY
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BU of 4ljy by Molmil
Crystal structure of RNA splicing effector Prp5 in complex with ADP
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Zhang, Z.-M, Li, J, Yang, F, Xu, Y, Zhou, J.
登録日2013-07-05
公開日2013-12-11
最終更新日2019-12-25
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Crystal structure of Prp5p reveals interdomain interactions that impact spliceosome assembly.
Cell Rep, 5, 2013
8K3J
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BU of 8k3j by Molmil
Structure of human CNTN2 immunoglobulin domains 1-6 homo-dimer
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Contactin-2, ...
著者Zhang, Z.Z.
登録日2023-07-16
公開日2024-07-17
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structure of human CNTN2 immunoglobulin domains 1-6 homo-dimer
To Be Published
5H4I
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BU of 5h4i by Molmil
Unlinked NS2B-NS3 Protease from Zika Virus in complex with a compound fragment
分子名称: ACETATE ION, NS2B cofactor, NS3 protease, ...
著者Zhang, Z.Z, Li, Y.
登録日2016-10-31
公開日2016-12-14
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.004 Å)
主引用文献Crystal structure of unlinked NS2B-NS3 protease from Zika virus
Science, 354, 2016
8FFK
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BU of 8ffk by Molmil
Klebsiella pneumoniae AcrB multidrug efflux pump apo form
分子名称: Efflux pump membrane transporter
著者Zhang, Z.
登録日2022-12-08
公開日2023-04-05
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (2.82 Å)
主引用文献Cryo-EM Structures of the Klebsiella pneumoniae AcrB Multidrug Efflux Pump.
Mbio, 14, 2023
8FFS
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BU of 8ffs by Molmil
Erythromycin bound Klebsiella pneumoniae AcrB multidrug efflux pump
分子名称: ERYTHROMYCIN A, Efflux pump membrane transporter
著者Zhang, Z.
登録日2022-12-09
公開日2023-04-05
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (2.96 Å)
主引用文献Cryo-EM Structures of the Klebsiella pneumoniae AcrB Multidrug Efflux Pump.
Mbio, 14, 2023
6WGN
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BU of 6wgn by Molmil
Crystal structure of K-Ras(G12D) GppNHp bound to cyclic peptide ligand KD2
分子名称: Cyclic Peptide KD2, GTPase KRas, MAGNESIUM ION, ...
著者Zhang, Z, Gao, R, Hu, Q, Peacock, H, Peacock, D.M, Shokat, K.M, Suga, H.
登録日2020-04-06
公開日2020-10-14
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.601 Å)
主引用文献GTP-State-Selective Cyclic Peptide Ligands of K-Ras(G12D) Block Its Interaction with Raf.
Acs Cent.Sci., 6, 2020
8K1W
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BU of 8k1w by Molmil
Crystal structure of PLA2 from Saccharothrix espanaensis
分子名称: PLA2
著者Zhang, Z.M, Wang, F.
登録日2023-07-11
公開日2024-07-24
実験手法X-RAY DIFFRACTION (1.30193019 Å)
主引用文献Crystal structure of PLA2 from Saccharothrix espanaensis
To Be Published
4RDD
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BU of 4rdd by Molmil
Co-crystal structure of SHP2 in complex with a Cefsulodin derivative
分子名称: 1-({(2R)-4-carboxy-2-[(R)-carboxy{[(2R)-2-phenyl-2-sulfoacetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazin-5-yl}methyl)pyridinium, Tyrosine-protein phosphatase non-receptor type 11
著者Zhang, Z.Y, Yu, Z.H, He, R, Zhang, R.Y.
登録日2014-09-18
公開日2015-07-01
最終更新日2015-12-16
実験手法X-RAY DIFFRACTION (1.601 Å)
主引用文献Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors.
ACS Med Chem Lett, 6, 2015
4GE6
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BU of 4ge6 by Molmil
Crystal structure of human protein tyrosine phosphatase PTPN9 (MEG2) complex with compound 7
分子名称: N-(4-bromo-3-methylbenzoyl)-4-[difluoro(phosphono)methyl]-L-phenylalanyl-N~5~-(3-iodobenzoyl)-L-ornithyl-3-{[(4-hydroxy-3-methoxyphenyl)acetyl]amino}-D-alaninamide, Tyrosine-protein phosphatase non-receptor type 9
著者Zhang, Z.-Y, Liu, S, Zhang, S.
登録日2012-08-01
公開日2012-10-31
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献A Highly Selective and Potent PTP-MEG2 Inhibitor with Therapeutic Potential for Type 2 Diabetes.
J.Am.Chem.Soc., 134, 2012
4N3X
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BU of 4n3x by Molmil
Crystal structure of Rabex-5 CC domain
分子名称: Rab5 GDP/GTP exchange factor
著者Zhang, Z, Zhang, T, Ding, J.
登録日2013-10-08
公開日2014-07-23
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5
Elife, 3, 2014

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