6WGN

Crystal structure of K-Ras(G12D) GppNHp bound to cyclic peptide ligand KD2

Summary for 6WGN

• Entry DOI: 10.2210/pdb6wgn/pdb
• Descriptor: GTPase KRas, Cyclic Peptide KD2, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (5 entities in total)
• Functional Keywords: inhibitor, k-ras, selective, cyclic peptide, signaling protein, signaling protein-inhibitor complex, signaling protein/inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 65224.00

Authors

Zhang, Z.,Gao, R.,Hu, Q.,Peacock, H.,Peacock, D.M.,Shokat, K.M.,Suga, H. (deposition date: 2020-04-06, release date: 2020-10-14, Last modification date: 2023-10-18)

• Primary citation: Zhang, Z.,Gao, R.,Hu, Q.,Peacock, H.,Peacock, D.M.,Dai, S.,Shokat, K.M.,Suga, H.; GTP-State-Selective Cyclic Peptide Ligands of K-Ras(G12D) Block Its Interaction with Raf.; Acs Cent.Sci., 6:1753-1761, 2020; PubMed: 33145412; DOI: 10.1021/acscentsci.0c00514

Experimental method

X-RAY DIFFRACTION (1.601 Å)