6WGN
Crystal structure of K-Ras(G12D) GppNHp bound to cyclic peptide ligand KD2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C | GTPase KRas | polymer | 169 | 19307.7 | 3 | UniProt (P01116) Pfam (PF00071) In PDB | Homo sapiens (Human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 2 | E, F, G | Cyclic Peptide KD2 | polymer | 15 | 1887.2 | 3 | Homo sapiens | ||
| 3 | A, B, C | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 3 | Chemie (GNP) | |||
| 4 | A, B, C | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 5 | water | water | 18.0 | 574 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 169 (UniProt: P01116)
| PDB | External Database | Details |
|---|---|---|
| Asp 12 | Gly 12 | engineered mutation |
| Ser 51 | Cys 51 | engineered mutation |
| Leu 80 | Cys 80 | engineered mutation |
| Ser 118 | Cys 118 | engineered mutation |
| Gly 151 | Arg 151 | conflict |
| Asp 153 | Glu 153 | conflict |
| Lys 165 | Gln 165 | conflict |
| His 166 | Tyr 166 | conflict |
| Lys 167 | Arg 167 | conflict |
| Glu 168 | Leu 168 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 63584.5 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1639.5 | |
| All* | Total formula weight | 65224.0 |
