6WGN
Crystal structure of K-Ras(G12D) GppNHp bound to cyclic peptide ligand KD2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005525 | molecular_function | GTP binding |
| A | 0007165 | biological_process | signal transduction |
| A | 0016020 | cellular_component | membrane |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005525 | molecular_function | GTP binding |
| B | 0007165 | biological_process | signal transduction |
| B | 0016020 | cellular_component | membrane |
| C | 0003924 | molecular_function | GTPase activity |
| C | 0005525 | molecular_function | GTP binding |
| C | 0007165 | biological_process | signal transduction |
| C | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 28 |
| Details | binding site for residue GNP A 201 |
| Chain | Residue |
| A | ASP12 |
| A | ASP30 |
| A | GLU31 |
| A | TYR32 |
| A | ASN116 |
| A | LYS117 |
| A | ASP119 |
| A | LEU120 |
| A | SER145 |
| A | ALA146 |
| A | LYS147 |
| A | GLY13 |
| A | MG202 |
| A | HOH311 |
| A | HOH318 |
| A | HOH346 |
| A | HOH359 |
| A | HOH370 |
| A | HOH401 |
| A | HOH409 |
| A | HOH415 |
| A | VAL14 |
| A | GLY15 |
| A | LYS16 |
| A | SER17 |
| A | ALA18 |
| A | PHE28 |
| A | VAL29 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 202 |
| Chain | Residue |
| A | SER17 |
| A | GNP201 |
| A | HOH346 |
| A | HOH359 |
| A | HOH401 |
| site_id | AC3 |
| Number of Residues | 28 |
| Details | binding site for residue GNP B 201 |
| Chain | Residue |
| B | ASP12 |
| B | GLY13 |
| B | VAL14 |
| B | GLY15 |
| B | LYS16 |
| B | SER17 |
| B | ALA18 |
| B | PHE28 |
| B | ASP30 |
| B | GLU31 |
| B | ASN116 |
| B | LYS117 |
| B | ASP119 |
| B | LEU120 |
| B | SER145 |
| B | ALA146 |
| B | LYS147 |
| B | MG202 |
| B | HOH310 |
| B | HOH327 |
| B | HOH347 |
| B | HOH353 |
| B | HOH398 |
| B | HOH403 |
| B | HOH405 |
| B | HOH406 |
| B | HOH414 |
| B | HOH427 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 202 |
| Chain | Residue |
| B | SER17 |
| B | GNP201 |
| B | HOH327 |
| B | HOH353 |
| B | HOH398 |
| site_id | AC5 |
| Number of Residues | 26 |
| Details | binding site for residue GNP C 201 |
| Chain | Residue |
| C | ASP12 |
| C | GLY13 |
| C | VAL14 |
| C | GLY15 |
| C | LYS16 |
| C | SER17 |
| C | ALA18 |
| C | ASN116 |
| C | LYS117 |
| C | ASP119 |
| C | LEU120 |
| C | SER145 |
| C | ALA146 |
| C | LYS147 |
| C | MG202 |
| C | HOH312 |
| C | HOH321 |
| C | HOH333 |
| C | HOH340 |
| C | HOH372 |
| C | HOH396 |
| C | HOH399 |
| C | HOH413 |
| C | HOH423 |
| C | HOH427 |
| C | HOH432 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue MG C 202 |
| Chain | Residue |
| C | SER17 |
| C | GNP201 |
| C | HOH333 |
| C | HOH372 |
| C | HOH399 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | binding site for Di-peptide GLY E 0 and DTY E 1 |
| Chain | Residue |
| C | TYR96 |
| E | PHE2 |
| E | THR10 |
| E | PHE11 |
| E | CYS13 |
| E | HOH107 |
| E | HOH108 |
| C | ASP92 |
| C | HIS95 |
| site_id | AC8 |
| Number of Residues | 14 |
| Details | binding site for Di-peptide DTY E 1 and PHE E 2 |
| Chain | Residue |
| C | ASP92 |
| C | HIS95 |
| C | TYR96 |
| C | GLN99 |
| E | GLY0 |
| E | VAL3 |
| E | ASN4 |
| E | PHE8 |
| E | ARG9 |
| E | THR10 |
| E | PHE11 |
| E | HOH103 |
| E | HOH107 |
| E | HOH112 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for Di-peptide GLY F 0 and DTY F 1 |
| Chain | Residue |
| A | ASP92 |
| A | TYR96 |
| F | PHE2 |
| F | THR10 |
| F | PHE11 |
| F | CYS13 |
| F | HOH106 |
| site_id | AD1 |
| Number of Residues | 14 |
| Details | binding site for Di-peptide DTY F 1 and PHE F 2 |
| Chain | Residue |
| A | ASP92 |
| A | HIS95 |
| A | TYR96 |
| A | GLN99 |
| F | GLY0 |
| F | VAL3 |
| F | ASN4 |
| F | PHE8 |
| F | ARG9 |
| F | THR10 |
| F | PHE11 |
| F | HOH103 |
| F | HOH106 |
| F | HOH109 |
| site_id | AD2 |
| Number of Residues | 9 |
| Details | binding site for Di-peptide GLY G 0 and DTY G 1 |
| Chain | Residue |
| B | ASP92 |
| B | HIS95 |
| B | TYR96 |
| G | PHE2 |
| G | THR10 |
| G | PHE11 |
| G | CYS13 |
| G | HOH113 |
| G | HOH114 |
| site_id | AD3 |
| Number of Residues | 15 |
| Details | binding site for Di-peptide DTY G 1 and PHE G 2 |
| Chain | Residue |
| B | GLN43 |
| B | ASP92 |
| B | HIS95 |
| B | TYR96 |
| B | GLN99 |
| B | HOH326 |
| G | GLY0 |
| G | VAL3 |
| G | ASN4 |
| G | PHE8 |
| G | ARG9 |
| G | THR10 |
| G | PHE11 |
| G | HOH109 |
| G | HOH113 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 36 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22431598","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22566140","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34380736","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35522713","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylmethionine; in GTPase KRas; alternate","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"N-acetylthreonine; in GTPase KRas, N-terminally processed","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"22711838","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
