6LW1

Cryo-EM structure of TLR7/Cpd-7 (DSR-139970) complex in open form

Summary for 6LW1

• Entry DOI: 10.2210/pdb6lw1/pdb
• EMDB information: 30002
• Descriptor: Toll-like receptor 7, 2-ethoxy-8-(5-fluoranylpyridin-3-yl)-6-methyl-9-[[4-[[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]phenyl]methyl]purine (2 entities in total)
• Functional Keywords: tlr7, antagonist, immune system
• Biological source: Macaca mulatta (Rhesus macaque)
• Total number of polymer chains: 2
• Total formula weight: 190466.33

Authors

Zhang, Z.,Ohto, U.,Shimizu, T. (deposition date: 2020-02-06, release date: 2020-11-11)

• Primary citation: Tojo, S.,Zhang, Z.,Matsui, H.,Tahara, M.,Ikeguchi, M.,Kochi, M.,Kamada, M.,Shigematsu, H.,Tsutsumi, A.,Adachi, N.,Shibata, T.,Yamamoto, M.,Kikkawa, M.,Senda, T.,Isobe, Y.,Ohto, U.,Shimizu, T.; Structural analysis reveals TLR7 dynamics underlying antagonism.; Nat Commun, 11:5204-5204, 2020; PubMed: 33060576; DOI: 10.1038/s41467-020-19025-z

Experimental method

ELECTRON MICROSCOPY (2.8 Å)