6LW1

Cryo-EM structure of TLR7/Cpd-7 (DSR-139970) complex in open form

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Toll-like receptor 7	polymer	823	94745.6	2	UniProt (B3Y653) Pfam (PF13855)	Macaca mulatta (Rhesus macaque)
2	C, D (A, B)	2-ethoxy-8-(5-fluoranylpyridin-3-yl)-6-methyl-9-[[4-[[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]phenyl]methyl]purine	non-polymer		487.6	2	Chemie (EX3)

Sequence modifications

A, B: 27 - 839 (UniProt: B3Y653)

PDB	External Database	Details
Arg 23	-	expression tag
Ser 24	-	expression tag
Pro 25	-	expression tag
Trp 26	-	expression tag
Gln 167	Asn 167	engineered mutation
Gln 389	Asn 389	engineered mutation
Leu 440	Ser 440	engineered mutation
Val 441	Glu 441	engineered mutation
Pro 442	Val 442	engineered mutation
Arg 443	Gly 443	engineered mutation
Gly 444	Phe 444	engineered mutation
Ser 445	Cys 445	engineered mutation
Gln 488	Asn 488	engineered mutation
Gln 799	Asn 799	engineered mutation
Glu 840	-	expression tag
Phe 841	-	expression tag
Leu 842	-	expression tag
Val 843	-	expression tag
Pro 844	-	expression tag
Arg 845	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	189491.2
Non-Polymers*	Number of molecules	2
	Total formula weight	975.1
All*	Total formula weight	190466.3

*Water molecules are not included.