8F4R
Gentamicin bound aminoglycoside efflux pump AcrD
Summary for 8F4R
Entry DOI | 10.2210/pdb8f4r/pdb |
EMDB information | 28857 |
Descriptor | Efflux pump membrane transporter, (2R,3R,4R,5R)-2-((1S,2S,3R,4S,6R)-4,6-DIAMINO-3-((2R,3R,6S)-3-AMINO-6-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-2-HYDR OXYCYCLOHEXYLOXY)-5-METHYL-4-(METHYLAMINO)-TETRAHYDRO-2H-PYRAN-3,5-DIOL (2 entities in total) |
Functional Keywords | aminoglycoside efflux pump, acrd, e.coli, membrane protein |
Biological source | Escherichia coli |
Total number of polymer chains | 3 |
Total formula weight | 339869.22 |
Authors | Zhang, Z. (deposition date: 2022-11-11, release date: 2022-12-28, Last modification date: 2024-06-19) |
Primary citation | Zhang, Z.,Morgan, C.E.,Cui, M.,Yu, E.W. Cryo-EM Structures of AcrD Illuminate a Mechanism for Capturing Aminoglycosides from Its Central Cavity. Mbio, 14:e0338322-e0338322, 2023 Cited by PubMed: 36625574DOI: 10.1128/mbio.03383-22 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.06 Å) |
Structure validation
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