6A0P
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![BU of 6a0p by Molmil](/molmil-images/mine/6a0p) | Crystal structure of Usutu virus envelope protein in the pre-fusion state | Descriptor: | Envelope protein | Authors: | Lu, G, Chen, Z, Ye, F, Lin, S, Yang, F, Cheng, Y. | Deposit date: | 2018-06-06 | Release date: | 2018-12-26 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of Usutu virus envelope protein in the pre-fusion state Virol. J., 15, 2018
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4X6R
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![BU of 4x6r by Molmil](/molmil-images/mine/4x6r) | An Isoform-specific Myristylation Switch Targets RIIb PKA Holoenzymes to Membranes | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | Authors: | Zhang, P, Ye, F, Bastidas, A.C, Kornev, A.P, Ginsberg, M.H, Wu, J, Taylor, S.S. | Deposit date: | 2014-12-09 | Release date: | 2015-07-22 | Last modified: | 2020-06-24 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes. Structure, 23, 2015
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4X6Q
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![BU of 4x6q by Molmil](/molmil-images/mine/4x6q) | An Isoform-specific Myristylation Switch Targets RIIb PKA Holoenzymes to Membranes | Descriptor: | cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase type II-beta regulatory subunit | Authors: | Zhang, P, Ye, F, Bastidas, A.C, Kornev, A.P, Ginsberg, M.H, Taylor, S.S. | Deposit date: | 2014-12-08 | Release date: | 2015-07-22 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes. Structure, 23, 2015
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3STA
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![BU of 3sta by Molmil](/molmil-images/mine/3sta) | Crystal structure of ClpP in tetradecameric form from Staphylococcus aureus | Descriptor: | ATP-dependent Clp protease proteolytic subunit | Authors: | Zhang, J, Ye, F, Lan, L, Jiang, H, Luo, C, Yang, C.-G. | Deposit date: | 2011-07-09 | Release date: | 2011-09-07 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Structural switching of Staphylococcus aureus Clp protease: a key to understanding protease dynamics J.Biol.Chem., 286, 2011
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3ST9
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![BU of 3st9 by Molmil](/molmil-images/mine/3st9) | Crystal structure of ClpP in heptameric form from Staphylococcus aureus | Descriptor: | ATP-dependent Clp protease proteolytic subunit, CALCIUM ION, GLYCEROL, ... | Authors: | Zhang, J, Ye, F, Lan, L, Jiang, H, Luo, C, Yang, C.-G. | Deposit date: | 2011-07-09 | Release date: | 2011-09-07 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.43 Å) | Cite: | Structural switching of Staphylococcus aureus Clp protease: a key to understanding protease dynamics J.Biol.Chem., 286, 2011
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6JHY
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![BU of 6jhy by Molmil](/molmil-images/mine/6jhy) | |
6JFW
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![BU of 6jfw by Molmil](/molmil-images/mine/6jfw) | Crystal structure of PA0833 periplasmic domain from Pseudomonas aeruginosa reveals an unexpected enlarged peptidoglycan binding pocket | Descriptor: | PA0833-PD protein | Authors: | Lin, X, Ye, F, Lin, S, Yang, F.L, Chen, Z.M, Cao, Y, Chen, Z.J, Gu, J, Lu, G.W. | Deposit date: | 2019-02-12 | Release date: | 2019-03-20 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.002 Å) | Cite: | Crystal structure of PA0833 periplasmic domain from Pseudomonas aeruginosa reveals an unexpected enlarged peptidoglycan binding pocket. Biochem. Biophys. Res. Commun., 511, 2019
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4R8G
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![BU of 4r8g by Molmil](/molmil-images/mine/4r8g) | Crystal Structure of Myosin-1c tail in complex with Calmodulin | Descriptor: | Calmodulin, SULFATE ION, Unconventional myosin-Ic | Authors: | Lu, Q, Li, J, Ye, F, Zhang, M. | Deposit date: | 2014-09-02 | Release date: | 2014-12-03 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (3.503 Å) | Cite: | Structure of myosin-1c tail bound to calmodulin provides insights into calcium-mediated conformational coupling. Nat.Struct.Mol.Biol., 22, 2015
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2M9H
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![BU of 2m9h by Molmil](/molmil-images/mine/2m9h) | |
2NA8
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![BU of 2na8 by Molmil](/molmil-images/mine/2na8) | Transmembrane Structure of the Cytokine Receptor Common Subunit beta | Descriptor: | Cytokine receptor common subunit beta | Authors: | Schmidt, T, Ye, F, Situ, A.J, An, W, Ginsberg, M.H, Ulmer, T.S. | Deposit date: | 2015-12-21 | Release date: | 2016-07-06 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | A Conserved Ectodomain-Transmembrane Domain Linker Motif Tunes the Allosteric Regulation of Cell Surface Receptors. J.Biol.Chem., 291, 2016
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2NA9
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![BU of 2na9 by Molmil](/molmil-images/mine/2na9) | Transmembrane Structure of the P441A Mutant of the Cytokine Receptor Common Subunit beta | Descriptor: | Cytokine receptor common subunit beta | Authors: | Schmidt, T, Ye, F, Situ, A.J, An, W, Ginsberg, M.H, Ulmer, T.S. | Deposit date: | 2015-12-21 | Release date: | 2016-07-06 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | A Conserved Ectodomain-Transmembrane Domain Linker Motif Tunes the Allosteric Regulation of Cell Surface Receptors. J.Biol.Chem., 291, 2016
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7C2J
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![BU of 7c2j by Molmil](/molmil-images/mine/7c2j) | Crystal structure of nsp16-nsp10 heterodimer from SARS-CoV-2 in complex with SAM (without additional SAM during crystallization) | Descriptor: | 2'-O-methyltransferase, Non-structural protein 10, S-ADENOSYLMETHIONINE, ... | Authors: | Lin, S, Chen, H, Ye, F, Chen, Z.M, Yang, F.L, Zheng, Y, Cao, Y, Qiao, J.X, Yang, S.Y, Lu, G.W. | Deposit date: | 2020-05-07 | Release date: | 2020-05-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.799 Å) | Cite: | Crystal structure of SARS-CoV-2 nsp10/nsp16 2'-O-methylase and its implication on antiviral drug design. Signal Transduct Target Ther, 5, 2020
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7C2I
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![BU of 7c2i by Molmil](/molmil-images/mine/7c2i) | Crystal structure of nsp16-nsp10 heterodimer from SARS-CoV-2 in complex with SAM (with additional SAM during crystallization) | Descriptor: | 2'-O-methyltransferase, Non-structural protein 10, S-ADENOSYLMETHIONINE, ... | Authors: | Lin, S, Chen, H, Ye, F, Chen, Z.M, Yang, F.L, Zheng, Y, Cao, Y, Qiao, J.X, Yang, S.Y, Lu, G.W. | Deposit date: | 2020-05-07 | Release date: | 2020-05-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of SARS-CoV-2 nsp10/nsp16 2'-O-methylase and its implication on antiviral drug design. Signal Transduct Target Ther, 5, 2020
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5TUB
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![BU of 5tub by Molmil](/molmil-images/mine/5tub) | Crystal Structure of the Shark TBC1D15 GAP Domain | Descriptor: | Shark TBC1D15 GTPase-activating Protein | Authors: | Chen, Y.-N, Wang, W, Cheng, D, Ge, Y, Gu, X, Zhou, X.E, Ye, F, Xu, H.E, Lv, Z. | Deposit date: | 2016-11-05 | Release date: | 2017-02-22 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Crystal structure of TBC1D15 GTPase-activating protein (GAP) domain and its activity on Rab GTPases. Protein Sci., 26, 2017
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5TUC
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![BU of 5tuc by Molmil](/molmil-images/mine/5tuc) | Crystal Structure of the Sus TBC1D15 GAP Domain | Descriptor: | Sus TBC1D15 GAP Domain | Authors: | Chen, Y.-N, Wang, W, Cheng, D, Ge, Y, Gu, X, Zhou, X.E, Ye, F, Xu, H.E, Lv, Z. | Deposit date: | 2016-11-05 | Release date: | 2017-02-22 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of TBC1D15 GTPase-activating protein (GAP) domain and its activity on Rab GTPases. Protein Sci., 26, 2017
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8JJP
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![BU of 8jjp by Molmil](/molmil-images/mine/8jjp) | G protein-coupled receptor 1 | Descriptor: | CHOLESTEROL, Chemerin-like receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Liu, A, Liu, Y, Chen, G, Ye, F. | Deposit date: | 2023-05-31 | Release date: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | G protein-coupled receptor 1 To Be Published
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5GUT
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![BU of 5gut by Molmil](/molmil-images/mine/5gut) | The crystal structure of mouse DNMT1 (731-1602) mutant - N1248A | Descriptor: | DNA (cytosine-5)-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ... | Authors: | Chen, S.J, Ye, F. | Deposit date: | 2016-08-31 | Release date: | 2017-09-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.099 Å) | Cite: | Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1. ACS Chem. Biol., 13, 2018
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7DIY
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![BU of 7diy by Molmil](/molmil-images/mine/7diy) | Crystal structure of SARS-CoV-2 nsp10 bound to nsp14-exoribonuclease domain | Descriptor: | MAGNESIUM ION, ZINC ION, nsp10 protein, ... | Authors: | Lin, S, Chen, H, Chen, Z.M, Yang, F.L, Ye, F, Zheng, Y, Yang, J, Lin, X, Sun, H.L, Wang, L.L, Wen, A, Cao, Y, Lu, G.W. | Deposit date: | 2020-11-19 | Release date: | 2021-05-19 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.693 Å) | Cite: | Crystal structure of SARS-CoV-2 nsp10 bound to nsp14-ExoN domain reveals an exoribonuclease with both structural and functional integrity. Nucleic Acids Res., 49, 2021
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7EFP
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![BU of 7efp by Molmil](/molmil-images/mine/7efp) | Structure of SARS-CoV-2 spike receptor-binding domain in complex with high affinity ACE2 mutant (S19W,N330Y) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, Spike glycoprotein | Authors: | Lu, G.W, Ye, F, Lin, X. | Deposit date: | 2021-03-22 | Release date: | 2021-11-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.698 Å) | Cite: | S19W, T27W, and N330Y mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular basis. Signal Transduct Target Ther, 6, 2021
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7EFR
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![BU of 7efr by Molmil](/molmil-images/mine/7efr) | Structure of SARS-CoV-2 spike receptor-binding domain in complex with high affinity ACE2 mutant (T27W,N330Y) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, Spike glycoprotein | Authors: | Lu, G.W, Ye, F, Lin, X. | Deposit date: | 2021-03-23 | Release date: | 2021-11-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.494 Å) | Cite: | S19W, T27W, and N330Y mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular basis. Signal Transduct Target Ther, 6, 2021
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4EJQ
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![BU of 4ejq by Molmil](/molmil-images/mine/4ejq) | Crystal structure of KIF1A C-CC1-FHA | Descriptor: | Kinesin-like protein KIF1A | Authors: | Huo, L, Yue, Y, Ren, J, Yu, J, Liu, J, Yu, Y, Ye, F, Xu, T, Zhang, M, Feng, W. | Deposit date: | 2012-04-06 | Release date: | 2012-10-03 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.893 Å) | Cite: | The CC1-FHA Tandem as a Central Hub for Controlling the Dimerization and Activation of Kinesin-3 KIF1A Structure, 20, 2012
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7DRT
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![BU of 7drt by Molmil](/molmil-images/mine/7drt) | Human Wntless in complex with Wnt3a | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Zhong, Q, Zhao, Y, Ye, F, Xiao, Z, Huang, G, Zhang, Y, Lu, P, Xu, W, Zhou, Q, Ma, D. | Deposit date: | 2020-12-29 | Release date: | 2021-07-14 | Last modified: | 2021-09-08 | Method: | ELECTRON MICROSCOPY (2.2 Å) | Cite: | Cryo-EM structure of human Wntless in complex with Wnt3a. Nat Commun, 12, 2021
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