4IG4
 
 | | Crystal structure of single mutant thermostable NPPase (N86S) from Geobacillus stearothermophilus | | Descriptor: | Thermostable NPPase | | Authors: | Guo, Z, Wang, F, Huang, J, Qiu, R, Yang, Z, Wang, Y, Gong, W, Ji, C. | | Deposit date: | 2012-12-16 | | Release date: | 2013-12-18 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.402 Å) | | Cite: | Crystal structure of thermostable NPPase from Geobacillus stearothermophilus
To be Published
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3IDX
 | | Crystal structure of HIV-gp120 core in complex with CD4-binding site antibody b13, space group C222 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Fab b13 heavy chain, ... | | Authors: | Chen, L, Kwon, Y.D, Zhou, T, Wu, X, O'Dell, S, Cavacini, L, Hessell, A.J, Pancera, M, Tang, M, Xu, L, Yang, Z.Y, Zhang, M.Y, Arthos, J, Burton, D.R, Dimitrov, D.S, Nabel, G.J, Posner, M, Sodroski, J, Wyatt, R, Mascola, J.R, Kwong, P.D. | | Deposit date: | 2009-07-22 | | Release date: | 2009-11-17 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural basis of immune evasion at the site of CD4 attachment on HIV-1 gp120.
Science, 326, 2009
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3IDY
 | | Crystal structure of HIV-gp120 core in complex with CD4-binding site antibody b13, space group C2221 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab b13 heavy chain, Fab b13 light chain, ... | | Authors: | Chen, L, Kwon, Y.D, Zhou, T, Wu, X, O'Dell, S, Cavacini, L, Hessell, A.J, Pancera, M, Tang, M, Xu, L, Yang, Z.Y, Zhang, M.Y, Arthos, J, Burton, D.R, Dimitrov, D.S, Nabel, G.J, Posner, M, Sodroski, J, Wyatt, R, Mascola, J.R, Kwong, P.D. | | Deposit date: | 2009-07-22 | | Release date: | 2009-11-17 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Structural basis of immune evasion at the site of CD4 attachment on HIV-1 gp120.
Science, 326, 2009
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5C7W
 | | 5'-monophosphate Z:P Guanine Riboswitch bound to hypoxanthine. | | Descriptor: | 5'-monophosphate Z:P guanine riboswitch, COBALT HEXAMMINE(III), HYPOXANTHINE | | Authors: | Hernandez, A.R, Shao, Y, Hoshika, S, Yang, Z, Shelke, S.A, Herrou, J, Kim, H.-J, Kim, M.-J, Piccirilli, J.A, Benner, S.A. | | Deposit date: | 2015-06-25 | | Release date: | 2015-08-12 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (3.22 Å) | | Cite: | A Crystal Structure of a Functional RNA Molecule Containing an Artificial Nucleobase Pair.
Angew.Chem.Int.Ed.Engl., 54, 2015
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5H7P
 | | NMR structure of the Vta1NTD-Did2(176-204) complex | | Descriptor: | Vacuolar protein sorting-associated protein VTA1, Vacuolar protein-sorting-associated protein 46 | | Authors: | Shen, J, Yang, Z, Wild, C.J. | | Deposit date: | 2016-11-20 | | Release date: | 2016-12-21 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | NMR studies on the interactions between yeast Vta1 and Did2 during the multivesicular bodies sorting pathway
Sci Rep, 6, 2016
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5C7U
 | | 5'-monophosphate wt Guanine Riboswitch bound to hypoxanthine. | | Descriptor: | 5'-monophosphate wt guanine riboswitch, COBALT HEXAMMINE(III), HYPOXANTHINE | | Authors: | Hernandez, A.R, Shao, Y, Hoshika, S, Yang, Z, Shelke, S.A, Herrou, J, Kim, H.-J, Kim, M.-J, Piccirilli, J.A, Benner, S.A. | | Deposit date: | 2015-06-24 | | Release date: | 2015-08-12 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3.05 Å) | | Cite: | A Crystal Structure of a Functional RNA Molecule Containing an Artificial Nucleobase Pair.
Angew.Chem.Int.Ed.Engl., 54, 2015
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1PJ4
 | | Crystal structure of human mitochondrial NAD(P)+-dependent malic enzyme in a pentary complex with natural substrate malate, ATP, Mn++, and allosteric activator fumarate. | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, D-MALATE, FUMARIC ACID, ... | | Authors: | Tao, X, Yang, Z, Tong, L. | | Deposit date: | 2003-05-31 | | Release date: | 2003-09-30 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structures of substrate complexes of malic enzyme and insights into the catalytic mechanism.
Structure, 11, 2003
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1PJ2
 | | Crystal structure of human mitochondrial NAD(P)+-dependent malic enzyme in a pentary complex with natural substrate malate, cofactor NADH, Mn++, and allosteric activator fumarate | | Descriptor: | (2S)-2-hydroxybutanedioic acid, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, FUMARIC ACID, ... | | Authors: | Tao, X, Yang, Z, Tong, L. | | Deposit date: | 2003-05-30 | | Release date: | 2003-11-11 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structures of substrate complexes of malic enzyme and insights into the catalytic mechanism.
Structure, 11, 2003
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1PJ3
 | | Crystal structure of human mitochondrial NAD(P)+-dependent malic enzyme in a pentary complex with natural substrate pyruvate, cofactor NAD+, Mn++, and allosteric activator fumarate. | | Descriptor: | FUMARIC ACID, MANGANESE (II) ION, NAD-dependent malic enzyme, ... | | Authors: | Tao, X, Yang, Z, Tong, L. | | Deposit date: | 2003-05-30 | | Release date: | 2003-11-11 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structures of substrate complexes of malic enzyme and insights into the catalytic mechanism.
Structure, 11, 2003
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3O5X
 | | Crystal structure of the oncogenic tyrosine phosphatase SHP2 complexed with a salicylic acid-based small molecule inhibitor | | Descriptor: | 3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3-triazol-4-yl}-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid, Tyrosine-protein phosphatase non-receptor type 11 | | Authors: | Zhang, Z.-Y, Zhang, X, He, Y, Liu, S, Yu, Z, Jiang, Z, Yang, Z, Dong, Y, Nabinger, S.C, Wu, L, Gunawan, A.M, Wang, L, Chan, R.J. | | Deposit date: | 2010-07-28 | | Release date: | 2010-08-11 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2).
J.Med.Chem., 53, 2010
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5IT5
 | | Thermus thermophilus PilB core ATPase region | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ATP binding motif-containing protein PilF, MAGNESIUM ION, ... | | Authors: | Mancl, J, Robinson, H, Black, W, Yang, Z, Schubot, F. | | Deposit date: | 2016-03-16 | | Release date: | 2016-10-19 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.648 Å) | | Cite: | Crystal Structure of a Type IV Pilus Assembly ATPase: Insights into the Molecular Mechanism of PilB from Thermus thermophilus.
Structure, 24, 2016
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6N3G
 | | Crystal structure of histone lysine methyltransferase SmyD2 in complex with polyethylene glycol | | Descriptor: | DODECAETHYLENE GLYCOL, ETHANOL, N-lysine methyltransferase SMYD2, ... | | Authors: | Perry, E, Spellmon, N, Brunzelle, J, Yang, Z. | | Deposit date: | 2018-11-15 | | Release date: | 2019-11-20 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.43 Å) | | Cite: | Crystal structure of histone lysine methyltransferase SmyD2 in complex with polyethylene glycol
To be Published
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3JZI
 | | Crystal structure of biotin carboxylase from E. Coli in complex with benzimidazole series | | Descriptor: | 7-amino-2-[(2-chlorobenzyl)amino]-1-{[(1S,2S)-2-hydroxycycloheptyl]methyl}-1H-benzimidazole-5-carboxamide, Biotin carboxylase | | Authors: | Cheng, C, Shipps, G.W, Yang, Z, Sun, B, Kawahata, N, Soucy, K, Soriano, A, Orth, P, Xiao, L, Mann, P, Black, T. | | Deposit date: | 2009-09-23 | | Release date: | 2009-11-03 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | Discovery and optimization of antibacterial AccC inhibitors.
Bioorg.Med.Chem.Lett., 19, 2009
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3DV2
 | | Crystal Structure of nicotinic acid mononucleotide adenylyltransferase from Bacillus anthracis | | Descriptor: | Nicotinate (Nicotinamide) nucleotide adenylyltransferase, SULFATE ION | | Authors: | Lu, S, Smith, C.D, Yang, Z, Pruett, P.S, Nagy, L, McCombs, D.P, DeLucas, L.J, Brouillette, W.J, Brouillette, C.G. | | Deposit date: | 2008-07-18 | | Release date: | 2008-11-04 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structure of nicotinic acid mononucleotide adenylyltransferase from Bacillus anthracis.
ACTA CRYSTALLOGR.,SECT.F, 64, 2008
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4Z0W
 | | Peptaibol gichigamin isolated from Tolypocladium sup_5 | | Descriptor: | PEPTAIBOL GICHIGAMIN | | Authors: | Du, L, Risinger, A.L, Mitchell, C.A, Stamps, B.W, Pan, N, King, J.B, Motley, J.L, Thomas, L.M, Yang, Z, Stevenson, B.S, Mooberry, S.L, Cichewicz, R.H. | | Deposit date: | 2015-03-26 | | Release date: | 2016-03-30 | | Last modified: | 2019-12-25 | | Method: | X-RAY DIFFRACTION (1.1 Å) | | Cite: | Peptaibol gichigamin isolated from Tolypocladium sup_5
TO BE PUBLISHED
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5AF0
 | | MAEL domain from Bombyx mori Maelstrom | | Descriptor: | MAELSTROM, ZINC ION | | Authors: | Chen, K, Campbell, E, Pandey, R.R, Yang, Z, McCarthy, A.A, Pillai, R.S. | | Deposit date: | 2015-01-13 | | Release date: | 2015-04-01 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.401 Å) | | Cite: | Metazoan Maelstrom is an RNA-Binding Protein that Has Evolved from an Ancient Nuclease Active in Protists.
RNA, 21, 2015
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1OD4
 | | Acetyl-CoA Carboxylase Carboxyltransferase Domain | | Descriptor: | ACETYL-COENZYME A CARBOXYLASE, ADENINE | | Authors: | Zhang, H, Yang, Z, Shen, Y, Tong, L. | | Deposit date: | 2003-02-12 | | Release date: | 2003-04-03 | | Last modified: | 2018-06-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase.
Science, 299, 2003
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4HBK
 | | Structure of the Aldose Reductase from Schistosoma japonicum | | Descriptor: | Aldo-keto reductase family 1, member B4 (Aldose reductase) | | Authors: | Liu, J, Cheng, J, Zhang, X, Yang, Z, Hu, W, Xu, Y. | | Deposit date: | 2012-09-28 | | Release date: | 2013-06-26 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Aldose reductase from Schistosoma japonicum: crystallization and structure-based inhibitor screening for discovering antischistosomal lead compounds.
Parasit Vectors, 6, 2013
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1OD2
 | | Acetyl-CoA Carboxylase Carboxyltransferase Domain | | Descriptor: | ACETYL COENZYME *A, ACETYL-COENZYME A CARBOXYLASE, ADENINE | | Authors: | Zhang, H, Yang, Z, Shen, Y, Tong, L. | | Deposit date: | 2003-02-12 | | Release date: | 2003-04-03 | | Last modified: | 2018-06-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase.
Science, 299, 2003
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5JZV
 | | The structure of D77G hCINAP-ADP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Adenylate kinase isoenzyme 6 | | Authors: | Liu, Y, Yang, Z, Yang, Y, Cai, X, Zheng, X. | | Deposit date: | 2016-05-17 | | Release date: | 2016-08-10 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.07 Å) | | Cite: | The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth.
Nat Commun, 7, 2016
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1PEG
 | | Structural basis for the product specificity of histone lysine methyltransferases | | Descriptor: | Histone H3, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION, ... | | Authors: | Zhang, X, Yang, Z, Khan, S.I, Horton, J.R, Tamaru, H, Selker, E.U, Cheng, X. | | Deposit date: | 2003-05-21 | | Release date: | 2003-08-05 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.59 Å) | | Cite: | Structural basis for the product specificity of histone lysine methyltransferases
Mol.Cell, 12, 2003
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1U2Z
 | | Crystal structure of histone K79 methyltransferase Dot1p from yeast | | Descriptor: | Histone-lysine N-methyltransferase, H3 lysine-79 specific, S-ADENOSYL-L-HOMOCYSTEINE | | Authors: | Sawada, K, Yang, Z, Horton, J.R, Collins, R.E, Zhang, X, Cheng, X. | | Deposit date: | 2004-07-20 | | Release date: | 2004-09-07 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structure of the conserved core of the yeast Dot1p, a nucleosomal histone H3 lysine 79 methyltransferase
J.Biol.Chem., 279, 2004
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7D77
 | | Cryo-EM structure of the cortisol-bound adhesion receptor GPR97-Go complex | | Descriptor: | (11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione, Adhesion G protein-coupled receptor G3; GPR97, CHOLESTEROL, ... | | Authors: | Ping, Y, Mao, C, Xiao, P, Zhao, R, Jiang, Y, Yang, Z, An, W, Shen, D, Yang, F, Zhang, H, Qu, C, Shen, Q, Tian, C, Li, Z, Li, S, Wang, G, Tao, X, Wen, X, Zhong, Y, Yang, J, Yi, F, Yu, X, Xu, E, Zhang, Y, Sun, J. | | Deposit date: | 2020-10-03 | | Release date: | 2021-02-03 | | Last modified: | 2021-02-10 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structures of the glucocorticoid-bound adhesion receptor GPR97-G o complex.
Nature, 589, 2021
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6BY7
 | | Folding DNA into a lipid-conjugated nano-barrel for controlled reconstitution of membrane proteins | | Descriptor: | DNA (26-MER), DNA (27-MER), DNA (29-MER), ... | | Authors: | Dong, Y, Chen, S, Zhang, S, Sodroski, J, Yang, Z, Liu, D, Mao, Y. | | Deposit date: | 2017-12-20 | | Release date: | 2018-02-28 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (7.5 Å) | | Cite: | Folding DNA into a Lipid-Conjugated Nanobarrel for Controlled Reconstitution of Membrane Proteins.
Angew. Chem. Int. Ed. Engl., 57, 2018
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7D76
 | | Cryo-EM structure of the beclomethasone-bound adhesion receptor GPR97-Go complex | | Descriptor: | (8~{S},9~{R},10~{S},11~{S},13~{S},14~{S},16~{S},17~{R})-9-chloranyl-10,13,16-trimethyl-11,17-bis(oxidanyl)-17-(2-oxidanylethanoyl)-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one, Adhesion G protein-coupled receptor G3; GPR97, CHOLESTEROL, ... | | Authors: | Ping, Y, Mao, C, Xiao, P, Zhao, R, Jiang, Y, Yang, Z, An, W, Shen, D, Yang, F, Zhang, H, Qu, C, Shen, Q, Tian, C, Li, Z, Li, S, Wang, G, Tao, X, Wen, X, Zhong, Y, Yang, J, Yi, F, Yu, X, Xu, E, Zhang, Y, Sun, J. | | Deposit date: | 2020-10-03 | | Release date: | 2021-02-03 | | Last modified: | 2021-02-10 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structures of the glucocorticoid-bound adhesion receptor GPR97-G o complex.
Nature, 589, 2021
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