6IH0

Aquifex aeolicus LpxC complex with ACHN-975

Summary for 6IH0

• Entry DOI: 10.2210/pdb6ih0/pdb
• Descriptor: UDP-3-O-acyl-N-acetylglucosamine deacetylase, N-[(2S)-3-azanyl-3-methyl-1-(oxidanylamino)-1-oxidanylidene-butan-2-yl]-4-[4-[(1R,2R)-2-(hydroxymethyl)cyclopropyl]buta -1,3-diynyl]benzamide, ZINC ION, ... (5 entities in total)
• Functional Keywords: inhibitor, complex, antibiotic, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Aquifex aeolicus (strain VF5)
• Total number of polymer chains: 1
• Total formula weight: 32741.78

Authors

Li, D.Y.,Fan, S.,Jin, Y.Y.,Zhang, C.,Lv, G.X.,Wu, G.T.,Yang, Z.Y. (deposition date: 2018-09-27, release date: 2019-01-30, Last modification date: 2023-11-22)

• Primary citation: Fan, S.,Li, D.,Yan, M.,Feng, X.,Lv, G.,Wu, G.,Jin, Y.,Wang, Y.,Yang, Z.; The Complex Structure of Protein AaLpxC from Aquifex aeolicus with ACHN-975 Molecule Suggests an Inhibitory Mechanism at Atomic-Level against Gram-Negative Bacteria; Molecules, 26:-, 2021; DOI: 10.3390/molecules26051451

Experimental method

X-RAY DIFFRACTION (1.21 Å)