5YLJ
| Crystal structure of T2R-TTL-Millepachine complex | Descriptor: | (E)-1-(5-methoxy-2,2-dimethyl-chromen-8-yl)-3-(4-methoxyphenyl)prop-2-en-1-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | Authors: | Yang, J.H, Chen, L.J. | Deposit date: | 2017-10-17 | Release date: | 2018-04-11 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin. J. Biol. Chem., 293, 2018
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5IFG
| Crystal structure of HigA-HigB complex from E. Coli | Descriptor: | Antitoxin HigA, mRNA interferase HigB | Authors: | Yang, J.S, Zhou, K, Gao, z.Q, Liu, Q.S, Dong, Y.H. | Deposit date: | 2016-02-26 | Release date: | 2017-03-01 | Method: | X-RAY DIFFRACTION (2.702 Å) | Cite: | Structural insight into the E. coli HigBA complex Biochem. Biophys. Res. Commun., 478, 2016
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8K2P
| Crystal structure of CtGST-F76A | Descriptor: | Glutathione S-transferase | Authors: | Yang, J, Xiao, J.Y, Lei, X.G. | Deposit date: | 2023-07-13 | Release date: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Enzymatic Degradation of Deoxynivalenol with the Engineered Detoxification Enzyme Fhb7. Jacs Au, 4, 2024
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8K2O
| Crystal structure of Fhb7-M10 | Descriptor: | Fhb7-M10 | Authors: | Yang, J, Lei, X.G, Xiao, J.Y. | Deposit date: | 2023-07-13 | Release date: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Enzymatic Degradation of Deoxynivalenol with the Engineered Detoxification Enzyme Fhb7. Jacs Au, 4, 2024
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7KIQ
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8IL3
| Cryo-EM structure of CD38 in complex with FTL004 | Descriptor: | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, Heavy chain, Light chain | Authors: | Yang, J, Wang, Y, Zhang, G. | Deposit date: | 2023-03-01 | Release date: | 2023-03-29 | Method: | ELECTRON MICROSCOPY (3.86 Å) | Cite: | FTL004, an anti-CD38 mAb with negligible RBC binding and enhanced pro-apoptotic activity, is a novel candidate for treatments of multiple myeloma and non-Hodgkin lymphoma. J Hematol Oncol, 15, 2022
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1RE5
| Crystal structure of 3-carboxy-cis,cis-muconate lactonizing enzyme from Pseudomonas putida | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 3-carboxy-cis,cis-muconate cycloisomerase, CITRIC ACID | Authors: | Yang, J, Wang, Y, Woolridge, E.M, Petsko, G.A, Kozarich, J.W, Ringe, D. | Deposit date: | 2003-11-06 | Release date: | 2004-06-08 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal Structure of 3-Carboxy-cis,cis-muconate Lactonizing Enzyme from Pseudomonas putida, a Fumarase Class II Type Cycloisomerase: Enzyme Evolution in Parallel Pathways. Biochemistry, 43, 2004
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8KFA
| Cryo-EM structure of HSV-1 gB with D48 Fab complex | Descriptor: | D48 heavy chain, D48 light chain, Envelope glycoprotein B | Authors: | Yang, J, Sun, C, Fang, X, Zeng, M, Liu, Z. | Deposit date: | 2023-08-15 | Release date: | 2024-01-03 | Method: | ELECTRON MICROSCOPY (3.04 Å) | Cite: | The structure of HSV-1 gB bound to a potent neutralizing antibody reveals a conservative antigenic domain across herpesviruses hlife, 2023
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1UTA
| Solution structure of the C-terminal RNP domain from the divisome protein FtsN | Descriptor: | CELL DIVISION PROTEIN FTSN | Authors: | Yang, J.-C, van den Ent, F, Neuhaus, D, Brevier, J, Lowe, J. | Deposit date: | 2003-12-04 | Release date: | 2004-09-24 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution Structure and Domain Architecture of the Divisome Protein Ftsn Mol.Microbiol., 52, 2004
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8H5T
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7SXO
| Yeast Lon (PIM1) with endogenous substrate | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Lon protease homolog, ... | Authors: | Yang, J, Song, A.S, Wiseman, R.L, Lander, G.C. | Deposit date: | 2021-11-24 | Release date: | 2022-01-12 | Last modified: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM structure of hexameric yeast Lon protease (PIM1) highlights the importance of conserved structural elements. J.Biol.Chem., 298, 2022
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2RMP
| RMP-pepstatin A complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MUCOROPEPSIN, PEPSTATIN, ... | Authors: | Yang, J, Quail, J.W. | Deposit date: | 1997-05-30 | Release date: | 1997-09-17 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure of the Rhizomucor miehei aspartic proteinase complexed with the inhibitor pepstatin A at 2.7 A resolution. Acta Crystallogr.,Sect.D, 55, 1999
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1NFQ
| Rv2002 gene product from Mycobacterium tuberculosis | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Androsterone, Putative oxidoreductase Rv2002 | Authors: | Yang, J.K, Park, M.S, Waldo, G.S, Suh, S.W, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2002-12-15 | Release date: | 2002-12-30 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Directed evolution approach to a structural genomics project: Rv2002 from Mycobacterium tuberculosis Proc.Natl.Acad.Sci.USA, 100, 2003
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1NFR
| Rv2002 gene product from Mycobacterium tuberculosis | Descriptor: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Putative oxidoreductase Rv2002 | Authors: | Yang, J.K, Park, M.S, Waldo, G.S, Suh, S.W, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2002-12-16 | Release date: | 2002-12-30 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Directed evolution approach to a structural genomics project: Rv2002 from Mycobacterium tuberculosis Proc.Natl.Acad.Sci.USA, 100, 2003
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3QAM
| Crystal Structure of Glu208Ala mutant of catalytic subunit of cAMP-dependent protein kinase | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Protein kinase inhibitor, ... | Authors: | Yang, J, Wu, J, Steichen, J, Taylor, S.S. | Deposit date: | 2011-01-11 | Release date: | 2011-12-07 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | A conserved Glu-Arg salt bridge connects coevolved motifs that define the eukaryotic protein kinase fold. J.Mol.Biol., 415, 2012
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3QAL
| Crystal Structure of Arg280Ala mutant of Catalytic subunit of cAMP-dependent Protein Kinase | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Protein kinase inhibitor, ... | Authors: | Yang, J, Wu, J, Steichen, J, Taylor, S.S. | Deposit date: | 2011-01-11 | Release date: | 2011-12-07 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | A conserved Glu-Arg salt bridge connects coevolved motifs that define the eukaryotic protein kinase fold. J.Mol.Biol., 415, 2012
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3R4L
| Human very long half life Plasminogen Activator Inhibitor type-1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Plasminogen activator inhibitor 1, beta-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Yang, J, Zheng, H, Han, Q, Skrzypczak-Jankun, E, Jankun, J. | Deposit date: | 2011-03-17 | Release date: | 2011-11-02 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Remarkable extension of PAI-1 half-life surprisingly brings no changes to its structure. Int.J.Mol.Med., 29, 2012
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3PYY
| Discovery and Characterization of a Cell-Permeable, Small-molecule c-Abl Kinase Activator that Binds to the Myristoyl Binding Site | Descriptor: | (5R)-5-[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]imidazolidine-2,4-dione, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, GLYCEROL, ... | Authors: | Yang, J, Campobasso, N, Biju, M.P, Fisher, K, Pan, X.Q, Cottom, J, Galbraith, S, Ho, T, Zhang, H, Hong, X, Ward, P, Hofmann, G, Siegfried, B. | Deposit date: | 2010-12-13 | Release date: | 2011-03-09 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Discovery and Characterization of a Cell-Permeable, Small-Molecule c-Abl Kinase Activator that Binds to the Myristoyl Binding Site. Chem.Biol., 18, 2011
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2Z61
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8J0P
| Chitin binding SusD-like protein AqSusD from a marine Bacteroidetes | Descriptor: | Chitin binding SusD-like protein | Authors: | Yang, J. | Deposit date: | 2023-04-11 | Release date: | 2023-11-01 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural insights of a SusD-like protein in marine Bacteroidetes bacteria reveal the molecular basis for chitin recognition and acquisition. Febs J., 291, 2024
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1RXT
| Crystal structure of human myristoyl-CoA:protein N-myristoyltransferase. | Descriptor: | COBALT (II) ION, Glycylpeptide N-tetradecanoyltransferase 1, SULFATE ION | Authors: | Yang, J, Wang, Y, Frey, G, Abeles, R.H, Petsko, G.A, Ringe, D. | Deposit date: | 2003-12-18 | Release date: | 2005-04-12 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of human myristoyl-CoA:protein N-myristoyltransferase To be Published
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3PUB
| Crystal structure of the Bombyx mori low molecular weight lipoprotein 7 (Bmlp7) | Descriptor: | 30kDa protein | Authors: | Yang, J.-P, Ma, X.-X, He, Y.-X, Li, W.-F, Kang, Y, Bao, R, Chen, Y, Zhou, C.-Z. | Deposit date: | 2010-12-03 | Release date: | 2011-06-01 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Crystal structure of the 30 K protein from the silkworm Bombyx mori reveals a new member of the beta-trefoil superfamily J.Struct.Biol., 175, 2011
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1NFF
| Crystal structure of Rv2002 gene product from Mycobacterium tuberculosis | Descriptor: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Putative oxidoreductase Rv2002 | Authors: | Yang, J.K, Park, M.S, Waldo, G.S, Suh, S.W, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2002-12-14 | Release date: | 2002-12-30 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Directed evolution approach to a structural genomics project: Rv2002 from Mycobacterium tuberculosis Proc.Natl.Acad.Sci.USA, 100, 2003
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8D9X
| Cryo-EM structure of human DELE1 in oligomeric form | Descriptor: | Maltodextrin-binding protein,DAP3-binding cell death enhancer 1 short form | Authors: | Yang, J, Lander, G.C. | Deposit date: | 2022-06-11 | Release date: | 2023-06-14 | Last modified: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | DELE1 oligomerization promotes integrated stress response activation. Nat.Struct.Mol.Biol., 30, 2023
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5YD0
| Crystal structure of Schlafen 13 (SLFN13) N'-domain | Descriptor: | Schlafen 8, ZINC ION | Authors: | Yang, J.-Y, Gao, S. | Deposit date: | 2017-09-09 | Release date: | 2018-03-28 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (3.182 Å) | Cite: | Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control Nat Commun, 9, 2018
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