5V43
| Engineered human IgG Fc domain aglyco801 | Descriptor: | Ig gamma-1 chain C region | Authors: | Yan, W, Marshall, N, Zhang, Y.J. | Deposit date: | 2017-03-08 | Release date: | 2017-06-21 | Last modified: | 2017-09-27 | Method: | X-RAY DIFFRACTION (2.32 Å) | Cite: | IgG Fc domains that bind C1q but not effector Fc gamma receptors delineate the importance of complement-mediated effector functions. Nat. Immunol., 18, 2017
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6OVG
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4Y5T
| Structure of FtmOx1 apo with metal Iron | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, COBALT (II) ION, FE (II) ION, ... | Authors: | Yan, W, Zhang, Y. | Deposit date: | 2015-02-12 | Release date: | 2015-11-04 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.949 Å) | Cite: | Endoperoxide formation by an alpha-ketoglutarate-dependent mononuclear non-haem iron enzyme. Nature, 527, 2015
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4Y5S
| Structure of FtmOx1 with a-Ketoglutarate as co-substrate | Descriptor: | 2-OXOGLUTARIC ACID, COBALT (II) ION, FE (II) ION, ... | Authors: | Yan, W, Zhang, Y. | Deposit date: | 2015-02-12 | Release date: | 2015-11-04 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.543 Å) | Cite: | Endoperoxide formation by an alpha-ketoglutarate-dependent mononuclear non-haem iron enzyme. Nature, 527, 2015
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6V65
| Crystal structure of KRAS(GMPPNP)-NF1(GRD)-SPRED1 complex | Descriptor: | FORMIC ACID, GTPase KRas, MAGNESIUM ION, ... | Authors: | Yan, W, Simanshu, D.K. | Deposit date: | 2019-12-04 | Release date: | 2020-07-15 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.763 Å) | Cite: | Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR. Cell Rep, 32, 2020
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6V6F
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5TT2
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5TSU
| Active conformation for Engineered human cystathionine gamma lyase (E59N, R119L, E339V) to depleting methionine | Descriptor: | CYSTEINE, Cystathionine gamma-lyase, METHIONINE, ... | Authors: | Yan, W, Zhang, Y. | Deposit date: | 2016-10-31 | Release date: | 2017-10-11 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural Snapshots of an Engineered Cystathionine-gamma-lyase Reveal the Critical Role of Electrostatic Interactions in the Active Site. Biochemistry, 56, 2017
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4JWH
| Crystal structure of spTrm10(Full length)-SAH complex | Descriptor: | S-ADENOSYL-L-HOMOCYSTEINE, tRNA (guanine(9)-N1)-methyltransferase | Authors: | Yan, W, Shao, Z. | Deposit date: | 2013-03-27 | Release date: | 2013-10-16 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate. Nucleic Acids Res., 42, 2014
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4JWJ
| Crystal structure of scTrm10(84)-SAH complex | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ... | Authors: | Yan, W, Shao, Z. | Deposit date: | 2013-03-27 | Release date: | 2013-10-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate. Nucleic Acids Res., 42, 2014
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3SQD
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4JWG
| Crystal structure of spTrm10(74) | Descriptor: | ACETIC ACID, tRNA (guanine(9)-N1)-methyltransferase | Authors: | Yan, W, Shao, Z. | Deposit date: | 2013-03-27 | Release date: | 2013-10-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate. Nucleic Acids Res., 42, 2014
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4JWF
| Crystal structure of spTrm10(74)-SAH complex | Descriptor: | ACETIC ACID, S-ADENOSYL-L-HOMOCYSTEINE, tRNA (guanine(9)-N1)-methyltransferase | Authors: | Yan, W, Shao, Z. | Deposit date: | 2013-03-27 | Release date: | 2013-10-16 | Last modified: | 2014-02-12 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate. Nucleic Acids Res., 42, 2014
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5V4E
| Engineered human IgG Fc domain glyco801 (Fc801) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Yan, W, Marshall, N, Zhang, Y.J. | Deposit date: | 2017-03-09 | Release date: | 2017-06-21 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.216 Å) | Cite: | IgG Fc domains that bind C1q but not effector Fc gamma receptors delineate the importance of complement-mediated effector functions. Nat. Immunol., 18, 2017
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5EIG
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7CKW
| Cryo-EM structure of Fenoldopam bound dopamine receptor DRD1-Gs signaling complex | Descriptor: | (1R)-6-chloranyl-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol, CHOLESTEROL, D(1A) dopamine receptor, ... | Authors: | Yan, W, Shao, W. | Deposit date: | 2020-07-20 | Release date: | 2021-03-03 | Method: | ELECTRON MICROSCOPY (3.22 Å) | Cite: | Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes. Cell, 184, 2021
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7X2E
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7CKX
| Cryo-EM structure of A77636 bound dopamine receptor DRD1-Gs signaling complex | Descriptor: | (1R,3S)-3-(1-adamantyl)-1-(aminomethyl)-3,4-dihydro-1H-isochromene-5,6-diol, CHOLESTEROL, D(1A) dopamine receptor, ... | Authors: | Yan, W, Shao, Z. | Deposit date: | 2020-07-20 | Release date: | 2021-03-03 | Method: | ELECTRON MICROSCOPY (3.54 Å) | Cite: | Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes. Cell, 184, 2021
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7CRH
| Cryo-EM structure of SKF83959 bound dopamine receptor DRD1-Gs signaling complex | Descriptor: | (1S)-6-chloranyl-3-methyl-1-(3-methylphenyl)-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol, D(1A) dopamine receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Yan, W, Shao, Z.H. | Deposit date: | 2020-08-13 | Release date: | 2021-03-03 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes. Cell, 184, 2021
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7CKY
| Cryo-EM structure of PW0464 bound dopamine receptor DRD1-Gs signaling complex | Descriptor: | 6-[4-[3-[bis(fluoranyl)methoxy]pyridin-2-yl]oxy-2-methyl-phenyl]-1,5-dimethyl-pyrimidine-2,4-dione, CHOLESTEROL, D(1A) dopamine receptor, ... | Authors: | Yan, W, Shao, Z. | Deposit date: | 2020-07-20 | Release date: | 2021-03-03 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes. Cell, 184, 2021
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7CKZ
| Cryo-EM structure of Dopamine and LY3154207 bound dopamine receptor DRD1-Gs signaling complex | Descriptor: | 2-[2,6-bis(chloranyl)phenyl]-1-[(1S,3R)-3-(hydroxymethyl)-1-methyl-5-(3-methyl-3-oxidanyl-butyl)-3,4-dihydro-1H-isoquinolin-2-yl]ethanone, CHOLESTEROL, D(1A) dopamine receptor, ... | Authors: | Yan, W, Shao, Z. | Deposit date: | 2020-07-20 | Release date: | 2021-03-03 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes. Cell, 184, 2021
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1T6W
| RATIONAL DESIGN OF A CALCIUM-BINDING ADHESION PROTEIN NMR, 20 STRUCTURES | Descriptor: | CALCIUM ION, hypothetical protein XP_346638 | Authors: | Yang, W, Wilkins, A.L, Ye, Y, Liu, Z.-R, Urbauer, J.L, Kearney, A, van der Merwe, P.A, Yang, J.J. | Deposit date: | 2004-05-07 | Release date: | 2005-02-15 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Design of a calcium-binding protein with desired structure in a cell adhesion molecule. J.Am.Chem.Soc., 127, 2005
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2IS2
| Crystal structure of UvrD-DNA binary complex | Descriptor: | 33-MER, DNA helicase II, FORMIC ACID, ... | Authors: | Yang, W, Lee, J.Y. | Deposit date: | 2006-10-16 | Release date: | 2007-01-09 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | UvrD helicase unwinds DNA one base pair at a time by a two-part power stroke. Cell(Cambridge,Mass.), 127, 2006
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2IS1
| Crystal structure of UvrD-DNA-SO4 complex | Descriptor: | 5'-D(*CP*GP*AP*GP*CP*AP*CP*TP*GP*C)-3', 5'-D(*GP*CP*AP*GP*TP*GP*CP*TP*CP*GP*TP*TP*TP*TP*TP*TP*T)-3', DNA helicase II, ... | Authors: | Yang, W, Lee, J.Y. | Deposit date: | 2006-10-16 | Release date: | 2007-01-09 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | UvrD helicase unwinds DNA one base pair at a time by a two-part power stroke. Cell(Cambridge,Mass.), 127, 2006
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2IS6
| Crystal structure of UvrD-DNA-ADPMgF3 ternary complex | Descriptor: | 5'-D(*CP*GP*AP*GP*CP*AP*CP*TP*GP*CP*AP*GP*TP*GP*CP*TP*CP*GP*TP*TP*GP*TP*TP*AP*T)-3', ADENOSINE-5'-DIPHOSPHATE, DNA helicase II, ... | Authors: | Yang, W, Lee, J.Y. | Deposit date: | 2006-10-16 | Release date: | 2007-01-09 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | UvrD helicase unwinds DNA one base pair at a time by a two-part power stroke. Cell(Cambridge,Mass.), 127, 2006
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