5YWH
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8HZ8
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1GDT
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7DA6
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7TVK
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7VMB
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7WWH
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8KHQ
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![BU of 8khq by Molmil](/molmil-images/mine/8khq) | Bifunctional sulfoxide synthase OvoA_Th2 in complex with histidine and cysteine | 分子名称: | 5-histidylcysteine sulfoxide synthase/putative 4-mercaptohistidine N1-methyltranferase, COBALT (II) ION, CYSTEINE, ... | 著者 | Wang, J, Ye, K, Wang, X.Y, Yan, W.P. | 登録日 | 2023-08-22 | 公開日 | 2023-12-06 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | Biochemical and Structural Characterization of OvoA Th2 : A Mononuclear Nonheme Iron Enzyme from Hydrogenimonas thermophila for Ovothiol Biosynthesis. Acs Catalysis, 13, 2023
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6P0Z
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![BU of 6p0z by Molmil](/molmil-images/mine/6p0z) | Crystal structure of N-acetylated KRAS (2-169) bound to GDP and Mg | 分子名称: | ACETYL GROUP, DI(HYDROXYETHYL)ETHER, GTPase KRas, ... | 著者 | Dharmaiah, S, Tran, T.H, Yan, W, Simanshu, D.K. | 登録日 | 2019-05-17 | 公開日 | 2019-07-31 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.011 Å) | 主引用文献 | Structures of N-terminally processed KRAS provide insight into the role of N-acetylation. Sci Rep, 9, 2019
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8JZ7
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![BU of 8jz7 by Molmil](/molmil-images/mine/8jz7) | Cryo-EM structure of MK-6892-bound HCAR2 in complex with Gi protein | 分子名称: | 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhao, C, Tian, X.W, Liu, Y, Cheng, L, Yan, W, Shao, Z.H. | 登録日 | 2023-07-04 | 公開日 | 2023-10-04 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Orthosteric ligand selectivity and allosteric probe dependence at Hydroxycarboxylic acid receptor HCAR2. Signal Transduct Target Ther, 8, 2023
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7YVR
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![BU of 7yvr by Molmil](/molmil-images/mine/7yvr) | Crystal Structure of L-Threonine Aldolase from Neptunomonas marina | 分子名称: | GLYCEROL, L-threonine aldolase | 著者 | He, Y.Z, Wang, J, Yan, W.P, Zhang, Y, Feng, Y. | 登録日 | 2022-08-19 | 公開日 | 2023-05-24 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Discovery and Engineering of the L-Threonine Aldolase from Neptunomonas marine for the Efficient Synthesis of beta-Hydroxy-alpha-amino Acids via C-C Formation Acs Catalysis, 2023
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7EXC
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![BU of 7exc by Molmil](/molmil-images/mine/7exc) | Crystal structure of T2R-TTL-1129A2 complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GLYCEROL, ... | 著者 | Yang, J.H, Yan, W. | 登録日 | 2021-05-26 | 公開日 | 2022-06-01 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Structure-Based Design and Synthesis of N-Substituted 3-Amino-beta-Carboline Derivatives as Potent alpha beta-Tubulin Degradation Agents J.Med.Chem., 65, 2022
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7Y67
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![BU of 7y67 by Molmil](/molmil-images/mine/7y67) | Cryo-EM structure of C089-bound C5aR1(I116A) mutant in complex with Gi protein | 分子名称: | C089 peptide, C5a anaphylatoxin chemotactic receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Feng, Y.Y, Zhao, C, Yan, W, Shao, Z.H. | 登録日 | 2022-06-18 | 公開日 | 2023-03-01 | 最終更新日 | 2023-04-19 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Mechanism of activation and biased signaling in complement receptor C5aR1. Cell Res., 33, 2023
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7Y64
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![BU of 7y64 by Molmil](/molmil-images/mine/7y64) | Cryo-EM structure of C5a-bound C5aR1 in complex with Gi protein | 分子名称: | C5a anaphylatoxin, C5a anaphylatoxin chemotactic receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Feng, Y.Y, Zhao, C, Yan, W, Shao, Z.H. | 登録日 | 2022-06-18 | 公開日 | 2023-03-01 | 最終更新日 | 2023-04-19 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Mechanism of activation and biased signaling in complement receptor C5aR1. Cell Res., 33, 2023
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7Y65
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![BU of 7y65 by Molmil](/molmil-images/mine/7y65) | Cryo-EM structure of C5a peptide-bound C5aR1 in complex with Gi protein | 分子名称: | C5a anaphylatoxin chemotactic receptor 1, C5apep peptide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Feng, Y.Y, Zhao, C, Yan, W, Shao, Z.H. | 登録日 | 2022-06-18 | 公開日 | 2023-03-01 | 最終更新日 | 2023-04-19 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Mechanism of activation and biased signaling in complement receptor C5aR1. Cell Res., 33, 2023
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7Y66
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![BU of 7y66 by Molmil](/molmil-images/mine/7y66) | Cryo-EM structure of BM213-bound C5aR1 in complex with Gi protein | 分子名称: | BM213 peptide, C5a anaphylatoxin chemotactic receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Feng, Y.Y, Zhao, C, Yan, W, Shao, Z.H. | 登録日 | 2022-06-18 | 公開日 | 2023-03-01 | 最終更新日 | 2023-04-19 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Mechanism of activation and biased signaling in complement receptor C5aR1. Cell Res., 33, 2023
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7CBZ
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![BU of 7cbz by Molmil](/molmil-images/mine/7cbz) | Crystal structure of T2R-TTL-A31 complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-[5-[4-[2-[4-(2-cyclopropylethanoyl)piperazin-1-yl]ethoxy]phenyl]pyridin-2-yl]-N-(phenylmethyl)ethanamide, CALCIUM ION, ... | 著者 | Yang, J.H, Yan, W. | 登録日 | 2020-06-15 | 公開日 | 2021-06-23 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | Design, Synthesis, and Bioactivity Evaluation of Dual-Target Inhibitors of Tubulin and Src Kinase Guided by Crystal Structure. J.Med.Chem., 64, 2021
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3RY0
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![BU of 3ry0 by Molmil](/molmil-images/mine/3ry0) | Crystal structure of TomN, a 4-Oxalocrotonate Tautomerase homologue in Tomaymycin biosynthetic pathway | 分子名称: | Putative tautomerase | 著者 | Zhang, Y, Yan, W.P, Li, W.Z, Whitman, C.P. | 登録日 | 2011-05-10 | 公開日 | 2011-08-17 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Kinetic, Crystallographic, and Mechanistic Characterization of TomN: Elucidation of a Function for a 4-Oxalocrotonate Tautomerase Homologue in the Tomaymycin Biosynthetic Pathway. Biochemistry, 50, 2011
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8SAI
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![BU of 8sai by Molmil](/molmil-images/mine/8sai) | Cryo-EM structure of GPR34-Gi complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Yong, X.H, Zhao, C, Yan, W, Shao, Z.H. | 登録日 | 2023-04-01 | 公開日 | 2023-10-04 | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | 主引用文献 | Cryo-EM structures of human GPR34 enable the identification of selective antagonists. Proc.Natl.Acad.Sci.USA, 120, 2023
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7EMJ
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![BU of 7emj by Molmil](/molmil-images/mine/7emj) | Crystal structure of T2R-TTL-Barbigerone complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 8,8-dimethyl-3-(2,4,5-trimethoxyphenyl)pyrano[2,3-f]chromen-4-one, CALCIUM ION, ... | 著者 | Yang, J.H, Yan, W. | 登録日 | 2021-04-14 | 公開日 | 2022-04-20 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | 主引用文献 | Crystal structure of tubulin-barbigerone complex enables rational design of potent anticancer agents with isoflavone skeleton. Phytomedicine, 109, 2023
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3JU5
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![BU of 3ju5 by Molmil](/molmil-images/mine/3ju5) | Crystal Structure of Dimeric Arginine Kinase at 1.75-A Resolution | 分子名称: | Arginine kinase, MAGNESIUM ION | 著者 | Wu, X, Ye, S, Guo, S, Yan, W, Bartlam, M, Rao, Z. | 登録日 | 2009-09-14 | 公開日 | 2009-09-29 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Structural basis for a reciprocating mechanism of negative cooperativity in dimeric phosphagen kinase activity Faseb J., 24, 2010
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3JU6
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![BU of 3ju6 by Molmil](/molmil-images/mine/3ju6) | Crystal Structure of Dimeric Arginine Kinase in Complex with AMPPNP and Arginine | 分子名称: | ARGININE, Arginine kinase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | 著者 | Wu, X, Ye, S, Guo, S, Yan, W, Bartlam, M, Rao, Z. | 登録日 | 2009-09-14 | 公開日 | 2009-09-29 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Structural basis for a reciprocating mechanism of negative cooperativity in dimeric phosphagen kinase activity Faseb J., 24, 2010
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3SHV
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6BOF
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3SHT
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