7EXC
Crystal structure of T2R-TTL-1129A2 complex
Summary for 7EXC
Entry DOI | 10.2210/pdb7exc/pdb |
Descriptor | Tubulin alpha-1B chain, N-[[3-(1,3-benzodioxol-5-yloxy)phenyl]methyl]-9H-pyrido[3,4-b]indol-3-amine, GUANOSINE-5'-DIPHOSPHATE, ... (13 entities in total) |
Functional Keywords | tubulin, cancer, cell cycle-inhibitor complex, cell cycle |
Biological source | Rattus norvegicus (Rat) More |
Total number of polymer chains | 6 |
Total formula weight | 270529.76 |
Authors | Yang, J.H.,Yan, W. (deposition date: 2021-05-26, release date: 2022-06-01, Last modification date: 2023-11-29) |
Primary citation | Li, Y.,Liu, Y.,Zhu, Z.,Yan, W.,Zhang, C.,Yang, Z.,Bai, P.,Tang, M.,Shi, M.,He, W.,Fu, S.,Liu, J.,Han, K.,Li, J.,Xie, L.,Ye, H.,Yang, J.,Chen, L. Structure-Based Design and Synthesis of N-Substituted 3-Amino-beta-Carboline Derivatives as Potent alpha beta-Tubulin Degradation Agents J.Med.Chem., 65:2675-2693, 2022 Cited by DOI: 10.1021/acs.jmedchem.1c02159PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.39 Å) |
Structure validation
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