Loading
PDBj
メニューPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 597 件

6OVG
DownloadVisualize
BU of 6ovg by Molmil
L-Methionine Depletion with an Engineered Human Enzyme Disrupts Prostate Cancer Metabolism
分子名称: Cystathionine gamma-lyase, SULFATE ION
著者Yan, W, Irani, S, Zhang, J.
登録日2019-05-07
公開日2020-04-22
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.719 Å)
主引用文献Enzyme-mediated depletion of serum l-Met abrogates prostate cancer growth via multiple mechanisms without evidence of systemic toxicity.
Proc.Natl.Acad.Sci.USA, 117, 2020
4Y5T
DownloadVisualize
BU of 4y5t by Molmil
Structure of FtmOx1 apo with metal Iron
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, COBALT (II) ION, FE (II) ION, ...
著者Yan, W, Zhang, Y.
登録日2015-02-12
公開日2015-11-04
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.949 Å)
主引用文献Endoperoxide formation by an alpha-ketoglutarate-dependent mononuclear non-haem iron enzyme.
Nature, 527, 2015
4Y5S
DownloadVisualize
BU of 4y5s by Molmil
Structure of FtmOx1 with a-Ketoglutarate as co-substrate
分子名称: 2-OXOGLUTARIC ACID, COBALT (II) ION, FE (II) ION, ...
著者Yan, W, Zhang, Y.
登録日2015-02-12
公開日2015-11-04
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.543 Å)
主引用文献Endoperoxide formation by an alpha-ketoglutarate-dependent mononuclear non-haem iron enzyme.
Nature, 527, 2015
5V4E
DownloadVisualize
BU of 5v4e by Molmil
Engineered human IgG Fc domain glyco801 (Fc801)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Yan, W, Marshall, N, Zhang, Y.J.
登録日2017-03-09
公開日2017-06-21
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3.216 Å)
主引用文献IgG Fc domains that bind C1q but not effector Fc gamma receptors delineate the importance of complement-mediated effector functions.
Nat. Immunol., 18, 2017
5V43
DownloadVisualize
BU of 5v43 by Molmil
Engineered human IgG Fc domain aglyco801
分子名称: Ig gamma-1 chain C region
著者Yan, W, Marshall, N, Zhang, Y.J.
登録日2017-03-08
公開日2017-06-21
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (2.32 Å)
主引用文献IgG Fc domains that bind C1q but not effector Fc gamma receptors delineate the importance of complement-mediated effector functions.
Nat. Immunol., 18, 2017
5TSU
DownloadVisualize
BU of 5tsu by Molmil
Active conformation for Engineered human cystathionine gamma lyase (E59N, R119L, E339V) to depleting methionine
分子名称: CYSTEINE, Cystathionine gamma-lyase, METHIONINE, ...
著者Yan, W, Zhang, Y.
登録日2016-10-31
公開日2017-10-11
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural Snapshots of an Engineered Cystathionine-gamma-lyase Reveal the Critical Role of Electrostatic Interactions in the Active Site.
Biochemistry, 56, 2017
6V65
DownloadVisualize
BU of 6v65 by Molmil
Crystal structure of KRAS(GMPPNP)-NF1(GRD)-SPRED1 complex
分子名称: FORMIC ACID, GTPase KRas, MAGNESIUM ION, ...
著者Yan, W, Simanshu, D.K.
登録日2019-12-04
公開日2020-07-15
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.763 Å)
主引用文献Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR.
Cell Rep, 32, 2020
6V6F
DownloadVisualize
BU of 6v6f by Molmil
Crystal structure of Q61L KRAS(GMPPNP)-NF1(GRD)-SPRED1(EVH1) complex
分子名称: FORMIC ACID, GTPase KRas, MAGNESIUM ION, ...
著者Yan, W, Simanshu, D.K.
登録日2019-12-05
公開日2020-07-15
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.542 Å)
主引用文献Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR.
Cell Rep, 32, 2020
5TT2
DownloadVisualize
BU of 5tt2 by Molmil
Inactive conformation of engineered human cystathionine gamma lyase (E59N, R119L, E339V) to depleting methionine
分子名称: Cystathionine gamma-lyase, SULFATE ION
著者Yan, W, Zhang, Y.
登録日2016-10-31
公開日2017-10-11
最終更新日2019-11-27
実験手法X-RAY DIFFRACTION (2.949 Å)
主引用文献Structural Snapshots of an Engineered Cystathionine-gamma-lyase Reveal the Critical Role of Electrostatic Interactions in the Active Site.
Biochemistry, 56, 2017
5EIG
DownloadVisualize
BU of 5eig by Molmil
Engineered human cystathionine gamma lyase (E59T, E339V) to deplet cysteine
分子名称: CYSTEINE, Cystathionine gamma-lyase, SULFATE ION
著者Yan, W, Zhang, J.
登録日2015-10-29
公開日2016-11-09
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Systemic Depletion of Serum L-Cyst(e)ine with an Engineered Human Enzyme Mediates Potent Induction of ROS and Cancer Ablation
To Be Published
3SQD
DownloadVisualize
BU of 3sqd by Molmil
Crystal structure of human PTIP BRCT5/6-gamma H2AX complex
分子名称: Histone H2A.x, PAX-interacting protein 1
著者Yan, W, Shao, Z.H.
登録日2011-07-05
公開日2011-11-09
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.153 Å)
主引用文献Crystal structure of human PTIP BRCT5/6-gamma H2AX
To be Published
4JWF
DownloadVisualize
BU of 4jwf by Molmil
Crystal structure of spTrm10(74)-SAH complex
分子名称: ACETIC ACID, S-ADENOSYL-L-HOMOCYSTEINE, tRNA (guanine(9)-N1)-methyltransferase
著者Yan, W, Shao, Z.
登録日2013-03-27
公開日2013-10-16
最終更新日2014-02-12
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate.
Nucleic Acids Res., 42, 2014
4JWH
DownloadVisualize
BU of 4jwh by Molmil
Crystal structure of spTrm10(Full length)-SAH complex
分子名称: S-ADENOSYL-L-HOMOCYSTEINE, tRNA (guanine(9)-N1)-methyltransferase
著者Yan, W, Shao, Z.
登録日2013-03-27
公開日2013-10-16
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate.
Nucleic Acids Res., 42, 2014
4JWJ
DownloadVisualize
BU of 4jwj by Molmil
Crystal structure of scTrm10(84)-SAH complex
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ...
著者Yan, W, Shao, Z.
登録日2013-03-27
公開日2013-10-16
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate.
Nucleic Acids Res., 42, 2014
4JWG
DownloadVisualize
BU of 4jwg by Molmil
Crystal structure of spTrm10(74)
分子名称: ACETIC ACID, tRNA (guanine(9)-N1)-methyltransferase
著者Yan, W, Shao, Z.
登録日2013-03-27
公開日2013-10-16
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate.
Nucleic Acids Res., 42, 2014
7CKW
DownloadVisualize
BU of 7ckw by Molmil
Cryo-EM structure of Fenoldopam bound dopamine receptor DRD1-Gs signaling complex
分子名称: (1R)-6-chloranyl-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol, CHOLESTEROL, D(1A) dopamine receptor, ...
著者Yan, W, Shao, W.
登録日2020-07-20
公開日2021-03-03
実験手法ELECTRON MICROSCOPY (3.22 Å)
主引用文献Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes.
Cell, 184, 2021
7CRH
DownloadVisualize
BU of 7crh by Molmil
Cryo-EM structure of SKF83959 bound dopamine receptor DRD1-Gs signaling complex
分子名称: (1S)-6-chloranyl-3-methyl-1-(3-methylphenyl)-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol, D(1A) dopamine receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Yan, W, Shao, Z.H.
登録日2020-08-13
公開日2021-03-03
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes.
Cell, 184, 2021
7CKY
DownloadVisualize
BU of 7cky by Molmil
Cryo-EM structure of PW0464 bound dopamine receptor DRD1-Gs signaling complex
分子名称: 6-[4-[3-[bis(fluoranyl)methoxy]pyridin-2-yl]oxy-2-methyl-phenyl]-1,5-dimethyl-pyrimidine-2,4-dione, CHOLESTEROL, D(1A) dopamine receptor, ...
著者Yan, W, Shao, Z.
登録日2020-07-20
公開日2021-03-03
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes.
Cell, 184, 2021
7CKZ
DownloadVisualize
BU of 7ckz by Molmil
Cryo-EM structure of Dopamine and LY3154207 bound dopamine receptor DRD1-Gs signaling complex
分子名称: 2-[2,6-bis(chloranyl)phenyl]-1-[(1S,3R)-3-(hydroxymethyl)-1-methyl-5-(3-methyl-3-oxidanyl-butyl)-3,4-dihydro-1H-isoquinolin-2-yl]ethanone, CHOLESTEROL, D(1A) dopamine receptor, ...
著者Yan, W, Shao, Z.
登録日2020-07-20
公開日2021-03-03
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes.
Cell, 184, 2021
7CKX
DownloadVisualize
BU of 7ckx by Molmil
Cryo-EM structure of A77636 bound dopamine receptor DRD1-Gs signaling complex
分子名称: (1R,3S)-3-(1-adamantyl)-1-(aminomethyl)-3,4-dihydro-1H-isochromene-5,6-diol, CHOLESTEROL, D(1A) dopamine receptor, ...
著者Yan, W, Shao, Z.
登録日2020-07-20
公開日2021-03-03
実験手法ELECTRON MICROSCOPY (3.54 Å)
主引用文献Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes.
Cell, 184, 2021
7X2E
DownloadVisualize
BU of 7x2e by Molmil
Structure of USH1C PDZ2 and coiled-coil in complex with CDHR2 C-terminal tail
分子名称: Cadherin-related family member 2, GLYCEROL, Harmonin
著者Yan, W, Chen, G, Li, J.
登録日2022-02-25
公開日2022-07-06
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structure of the Harmonin PDZ2 and coiled-coil domains in a complex with CDHR2 tail and its implications.
Faseb J., 36, 2022
3HF2
DownloadVisualize
BU of 3hf2 by Molmil
Crystal structure of the I401P mutant of cytochrome P450 BM3
分子名称: Bifunctional P-450/NADPH-P450 reductase, PROTOPORPHYRIN IX CONTAINING FE
著者Yang, W, Whitehouse, C.J.C, Bell, S.G, Bartlam, M, Wong, L.L, Rao, Z.
登録日2009-05-10
公開日2009-06-30
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献A Highly Active Single-Mutation Variant of P450(BM3) (CYP102A1)
Chembiochem, 10, 2009
1T6W
DownloadVisualize
BU of 1t6w by Molmil
RATIONAL DESIGN OF A CALCIUM-BINDING ADHESION PROTEIN NMR, 20 STRUCTURES
分子名称: CALCIUM ION, hypothetical protein XP_346638
著者Yang, W, Wilkins, A.L, Ye, Y, Liu, Z.-R, Urbauer, J.L, Kearney, A, van der Merwe, P.A, Yang, J.J.
登録日2004-05-07
公開日2005-02-15
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Design of a calcium-binding protein with desired structure in a cell adhesion molecule.
J.Am.Chem.Soc., 127, 2005
1RNH
DownloadVisualize
BU of 1rnh by Molmil
STRUCTURE OF RIBONUCLEASE H PHASED AT 2 ANGSTROMS RESOLUTION BY MAD ANALYSIS OF THE SELENOMETHIONYL PROTEIN
分子名称: RIBONUCLEASE HI, SULFATE ION
著者Yang, W, Hendrickson, W.A, Crouch, R.J, Satow, Y.
登録日1990-07-11
公開日1991-10-15
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of ribonuclease H phased at 2 A resolution by MAD analysis of the selenomethionyl protein.
Science, 249, 1990
1K0P
DownloadVisualize
BU of 1k0p by Molmil
NMR Structures of the Zinc Finger Domain of Human DNA Polymerase-alpha
分子名称: DNA polymerase alpha catalytic subunit
著者Yang, W.W, Evanics, F, Basu, S, Bose, R.N.
登録日2001-09-20
公開日2003-06-24
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Nuclear magnetic resonance structures of the zinc finger domain of human DNA polymerase-alpha.
Biochim.Biophys.Acta, 1651, 2003

222415

件を2024-07-10に公開中

PDB statisticsPDBj update infoContact PDBjnumon