6O9L
 
 | | Human holo-PIC in the closed state | | 分子名称: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | | 著者 | Yan, C.L, Dodd, T, He, Y, Tainer, J.A, Tsutakawa, S.E, Ivanov, I. | | 登録日 | 2019-03-14 | | 公開日 | 2019-05-29 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (7.2 Å) | | 主引用文献 | Transcription preinitiation complex structure and dynamics provide insight into genetic diseases.
Nat.Struct.Mol.Biol., 26, 2019
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6O9M
 | | Structure of the human apo TFIIH | | 分子名称: | CDK-activating kinase assembly factor MAT1, General transcription factor IIH subunit 1, General transcription factor IIH subunit 2, ... | | 著者 | Yan, C.L, Dodd, T, He, Y, Tainer, J.A, Tsutakawa, S.E, Ivanov, I. | | 登録日 | 2019-03-14 | | 公開日 | 2019-05-29 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | | 主引用文献 | Transcription preinitiation complex structure and dynamics provide insight into genetic diseases.
Nat.Struct.Mol.Biol., 26, 2019
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3JB9
 | | Cryo-EM structure of the yeast spliceosome at 3.6 angstrom resolution | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Yan, C, Hang, J, Wan, R, Huang, M, Wong, C, Shi, Y. | | 登録日 | 2015-08-09 | | 公開日 | 2015-09-23 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structure of a yeast spliceosome at 3.6-angstrom resolution
Science, 349, 2015
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5GM6
 | | Cryo-EM structure of the activated spliceosome (Bact complex) at 3.5 angstrom resolution | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Cold sensitive U2 snRNA suppressor 1, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Yan, C, Wan, R, Bai, R, Huang, G, Shi, Y. | | 登録日 | 2016-07-12 | | 公開日 | 2016-09-21 | | 最終更新日 | 2019-11-06 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structure of a yeast activated spliceosome at 3.5 angstrom resolution
Science, 353, 2016
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5WSG
 | | Cryo-EM structure of the Catalytic Step II spliceosome (C* complex) at 4.0 angstrom resolution | | 分子名称: | 3'-exon-intron, 3'-intron-lariat, 5'-exon, ... | | 著者 | Yan, C, Wan, R, Bai, R, Huang, G, Shi, Y. | | 登録日 | 2016-12-07 | | 公開日 | 2017-01-25 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Structure of a yeast step II catalytically activated spliceosome
Science, 355, 2017
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7E27
 | | Structure of PfFNT in complex with MMV007839 | | 分子名称: | (Z)-4,4,5,5,5-pentakis(fluoranyl)-1-(4-methoxy-2-oxidanyl-phenyl)-3-oxidanyl-pent-2-en-1-one, Formate-nitrite transporter | | 著者 | Yan, C.Y, Jiang, X, Deng, D, Peng, X, Wang, N, Zhu, A, Xu, H, Li, J. | | 登録日 | 2021-02-04 | | 公開日 | 2021-08-18 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (2.29 Å) | | 主引用文献 | Structural characterization of the Plasmodium falciparum lactate transporter PfFNT alone and in complex with antimalarial compound MMV007839 reveals its inhibition mechanism.
Plos Biol., 19, 2021
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7E26
 | | Structure of PfFNT in apo state | | 分子名称: | Formate-nitrite transporter | | 著者 | Yan, C.Y, Jiang, X, Deng, D, Peng, X, Wang, N, Zhu, A, Xu, H, Li, J. | | 登録日 | 2021-02-04 | | 公開日 | 2021-08-18 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (2.29 Å) | | 主引用文献 | Structural characterization of the Plasmodium falciparum lactate transporter PfFNT alone and in complex with antimalarial compound MMV007839 reveals its inhibition mechanism.
Plos Biol., 19, 2021
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3BTX
 | | X-ray structure of human ABH2 bound to dsDNA through active site cross-linking | | 分子名称: | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2, DNA (5'-D(*CP*TP*GP*TP*AP*TP*(2YR)P*AP*TP*TP*GP*CP*G)-3'), DNA (5'-D(*DTP*DCP*DGP*DCP*DAP*DAP*DTP*DAP*DAP*DTP*DAP*DCP*DA)-3'), ... | | 著者 | Yang, C.-G, Yi, C, He, C. | | 登録日 | 2007-12-31 | | 公開日 | 2008-04-22 | | 最終更新日 | 2021-10-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA.
Nature, 452, 2008
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7MEI
 | | Composite structure of EC+EC | | 分子名称: | DNA (74-MER), DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB3, ... | | 著者 | Yang, C, Murakami, K. | | 登録日 | 2021-04-06 | | 公開日 | 2022-03-02 | | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | | 主引用文献 | Structural visualization of de novo transcription initiation by Saccharomyces cerevisiae RNA polymerase II.
Mol.Cell, 82, 2022
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3ULL
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7MKA
 | | Structure of EC+EC (leading EC-focused) | | 分子名称: | DNA (40-MER), DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB3, ... | | 著者 | Yang, C, Murakami, K. | | 登録日 | 2021-04-22 | | 公開日 | 2022-04-27 | | 最終更新日 | 2023-05-17 | | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | | 主引用文献 | Structural visualization of de novo transcription initiation by Saccharomyces cerevisiae RNA polymerase II.
Mol.Cell, 82, 2022
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4FKZ
 | | Crystal structure of Bacillus subtilis UDP-GlcNAc 2-epimerase in complex with UDP-GlcNAc and UDP | | 分子名称: | UDP-N-acetylglucosamine 2-epimerase, URIDINE-5'-DIPHOSPHATE, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE | | 著者 | Yang, C.S, Chen, S.C, Kuan, S.M, Chen, Y.R, Liu, Y.H, Chen, Y. | | 登録日 | 2012-06-14 | | 公開日 | 2013-05-08 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | | 主引用文献 | Crystal structure of Bacillus subtilis UDP-GlcNAc 2-epimerase in complex with UDP-GlcNAc and UDP
To be Published
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7ML0
 | | RNA polymerase II pre-initiation complex (PIC1) | | 分子名称: | BJ4_G0050160.mRNA.1.CDS.1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB3, ... | | 著者 | Yang, C, Fujiwara, R, Kim, H.J, Gorbea Colon, J.J, Steimle, S, Garcia, B.A, Murakami, K. | | 登録日 | 2021-04-27 | | 公開日 | 2022-02-02 | | 最終更新日 | 2022-02-16 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural visualization of de novo transcription initiation by Saccharomyces cerevisiae RNA polymerase II.
Mol.Cell, 82, 2022
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7ML1
 | | RNA polymerase II pre-initiation complex (PIC2) | | 分子名称: | BJ4_G0050160.mRNA.1.CDS.1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB3, ... | | 著者 | Yang, C, Fujiwara, R, Kim, H.J, Gorbea Colon, J.J, Steimle, S, Garcia, B.A, Murakami, K. | | 登録日 | 2021-04-27 | | 公開日 | 2022-02-02 | | 最終更新日 | 2022-02-16 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Structural visualization of de novo transcription initiation by Saccharomyces cerevisiae RNA polymerase II.
Mol.Cell, 82, 2022
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7ML4
 | | RNA polymerase II initially transcribing complex (ITC) | | 分子名称: | BJ4_G0050160.mRNA.1.CDS.1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB3, ... | | 著者 | Yang, C, Fujiwara, R, Kim, H.J, Gorbea Colon, J.J, Steimle, S, Garcia, B.A, Murakami, K. | | 登録日 | 2021-04-27 | | 公開日 | 2022-02-02 | | 最終更新日 | 2022-03-09 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural visualization of de novo transcription initiation by Saccharomyces cerevisiae RNA polymerase II.
Mol.Cell, 82, 2022
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7ML3
 | | General transcription factor TFIIH (weak binding) | | 分子名称: | BJ4_G0050160.mRNA.1.CDS.1, General transcription and DNA repair factor IIH, General transcription and DNA repair factor IIH helicase subunit XPB, ... | | 著者 | Yang, C, Fujiwara, R, Kim, H.J, Gorbea Colon, J.J, Steimle, S, Garcia, B.A, Murakami, K. | | 登録日 | 2021-04-27 | | 公開日 | 2022-02-02 | | 最終更新日 | 2022-02-16 | | 実験手法 | ELECTRON MICROSCOPY (7.6 Å) | | 主引用文献 | Structural visualization of de novo transcription initiation by Saccharomyces cerevisiae RNA polymerase II.
Mol.Cell, 82, 2022
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7ML2
 | | RNA polymerase II pre-initiation complex (PIC3) | | 分子名称: | BJ4_G0004860.mRNA.1.CDS.1, BJ4_G0050160.mRNA.1.CDS.1, DNA-directed RNA polymerase II subunit RPB11, ... | | 著者 | Yang, C, Fujiwara, R, Kim, H.J, Gorbea Colon, J.J, Steimle, S, Garcia, B.A, Murakami, K. | | 登録日 | 2021-04-27 | | 公開日 | 2022-02-02 | | 最終更新日 | 2022-02-16 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural visualization of de novo transcription initiation by Saccharomyces cerevisiae RNA polymerase II.
Mol.Cell, 82, 2022
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7MK9
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3KRN
 | | Crystal Structure of C. elegans cell-death-related nuclease 5(CRN-5) | | 分子名称: | Protein C14A4.5, confirmed by transcript evidence | | 著者 | Yang, C.-C, Wang, Y.-T, Hsiao, Y.-Y, Doudeva, L.G, Chow, S.Y, Yuan, H.S. | | 登録日 | 2009-11-19 | | 公開日 | 2010-01-26 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (3.918 Å) | | 主引用文献 | Structural and biochemical characterization of CRN-5 and Rrp46: an exosome component participating in apoptotic DNA degradation
Rna, 16, 2010
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6K5H
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7CKK
 | | Structural complex of FTO bound with Dac51 | | 分子名称: | 2-{[2,6-dichloro-4-(3,5-dimethyl-1H-pyrazol-4-yl)phenyl]amino}-N-hydroxybenzamide, Alpha-ketoglutarate-dependent dioxygenase FTO, N-OXALYLGLYCINE | | 著者 | Yang, C, Gan, J. | | 登録日 | 2020-07-17 | | 公開日 | 2021-07-21 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance.
Cell Metab., 33, 2021
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2L4V
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3DFG
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6XXV
 | | Crystal Structure of a computationally designed Immunogen S2_1.2 in complex with its elicited antibody C57 | | 分子名称: | Antibody C57, Heavy Chain, Light Chain, ... | | 著者 | Yang, C, Sesterhenn, F, Correia, B.E, Pojer, F. | | 登録日 | 2020-01-28 | | 公開日 | 2020-04-22 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.20116425 Å) | | 主引用文献 | De novo protein design enables the precise induction of RSV-neutralizing antibodies.
Science, 368, 2020
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6YWC
 | | De novo designed protein 4E1H_95 in complex with 101F antibody | | 分子名称: | Antibody 101F, Heavy Chain, light chain, ... | | 著者 | Yang, C, Sesterhenn, F, Pojer, F, Correia, B.E. | | 登録日 | 2020-04-29 | | 公開日 | 2020-10-07 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Bottom-up de novo design of functional proteins with complex structural features.
Nat.Chem.Biol., 17, 2021
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