7CKK

Structural complex of FTO bound with Dac51

Summary for 7CKK

• Entry DOI: 10.2210/pdb7ckk/pdb
• Descriptor: Alpha-ketoglutarate-dependent dioxygenase FTO, N-OXALYLGLYCINE, 2-{[2,6-dichloro-4-(3,5-dimethyl-1H-pyrazol-4-yl)phenyl]amino}-N-hydroxybenzamide, ... (4 entities in total)
• Functional Keywords: inhibitor, complex, demethylase, rna binding protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 54916.63

Authors

Yang, C.,Gan, J. (deposition date: 2020-07-17, release date: 2021-07-21, Last modification date: 2023-11-29)

• Primary citation: Liu, Y.,Liang, G.,Xu, H.,Dong, W.,Dong, Z.,Qiu, Z.,Zhang, Z.,Li, F.,Huang, Y.,Li, Y.,Wu, J.,Yin, S.,Zhang, Y.,Guo, P.,Liu, J.,Xi, J.J.,Jiang, P.,Han, D.,Yang, C.G.,Xu, M.M.; Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance.; Cell Metab., 33:1221-1233.e11, 2021; PubMed: 33910046; DOI: 10.1016/j.cmet.2021.04.001

Experimental method

X-RAY DIFFRACTION (2.35 Å)