8X17
 
 | | Cryo-EM structure of adenosine receptor A3AR bound to CF102 | | Descriptor: | Adenosine receptor A3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Cai, H, Xu, Y, Xu, H.E. | | Deposit date: | 2023-11-06 | | Release date: | 2024-04-24 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (3.19 Å) | | Cite: | Cryo-EM structures of adenosine receptor A 3 AR bound to selective agonists.
Nat Commun, 15, 2024
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8F7W
 | | Gi bound kappa-opioid receptor in complex with dynorphin | | Descriptor: | CHOLESTEROL, Dynorphin, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Wang, Y, Zhuang, Y, DiBerto, J.F, Zhou, X.E, Schmitz, G.P, Yuan, Q, Jain, M.K, Liu, W, Melcher, K, Jiang, Y, Roth, B.L, Xu, H.E. | | Deposit date: | 2022-11-20 | | Release date: | 2022-12-14 | | Last modified: | 2023-02-01 | | Method: | ELECTRON MICROSCOPY (3.19 Å) | | Cite: | Structures of the entire human opioid receptor family.
Cell, 186, 2023
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8F7S
 | | Gi bound delta-opioid receptor in complex with deltorphin | | Descriptor: | CHOLESTEROL, Delta-type opioid receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Wang, Y, Zhuang, Y, DiBerto, J.F, Zhou, X.E, Schmitz, G.P, Yuan, Q, Jain, M.K, Liu, W, Melcher, K, Jiang, Y, Roth, B.L, Xu, H.E. | | Deposit date: | 2022-11-20 | | Release date: | 2022-12-14 | | Last modified: | 2023-02-01 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structures of the entire human opioid receptor family.
Cell, 186, 2023
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8F7Q
 | | Gi bound mu-opioid receptor in complex with beta-endorphin | | Descriptor: | Beta-endorphin, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Wang, Y, Zhuang, Y, DiBerto, J.F, Zhou, X.E, Schmitz, G.P, Yuan, Q, Jain, M.K, Liu, W, Melcher, K, Jiang, Y, Roth, B.L, Xu, H.E. | | Deposit date: | 2022-11-20 | | Release date: | 2022-12-14 | | Last modified: | 2023-02-01 | | Method: | ELECTRON MICROSCOPY (3.22 Å) | | Cite: | Structures of the entire human opioid receptor family.
Cell, 186, 2023
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8F7R
 | | Gi bound mu-opioid receptor in complex with endomorphin | | Descriptor: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Wang, Y, Zhuang, Y, DiBerto, J.F, Zhou, X.E, Schmitz, G.P, Yuan, Q, Jain, M.K, Liu, W, Melcher, K, Jiang, Y, Roth, B.L, Xu, H.E. | | Deposit date: | 2022-11-20 | | Release date: | 2022-12-14 | | Last modified: | 2023-02-01 | | Method: | ELECTRON MICROSCOPY (3.28 Å) | | Cite: | Structures of the entire human opioid receptor family.
Cell, 186, 2023
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8X79
 | | MRE-269 bound Prostacyclin Receptor G protein complex | | Descriptor: | 2-[4-[(5,6-diphenylpyrazin-2-yl)-propan-2-yl-amino]butoxy]ethanoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Wang, J.J, Jin, S, Zhang, H, Xu, Y, Hu, W, Jiang, Y, Chen, C, Wang, D.W, Xu, H.E, Wu, C. | | Deposit date: | 2023-11-23 | | Release date: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (2.41 Å) | | Cite: | Molecular recognition and activation of the prostacyclin receptor by anti-pulmonary arterial hypertension drugs.
Sci Adv, 10, 2024
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8XIQ
 | | Structure of L796778-SSTR3 G protein complex | | Descriptor: | G-alpha i, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Wang, Y, Xu, Y, Xu, H.E, Zhuang, Y. | | Deposit date: | 2023-12-19 | | Release date: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (2.71 Å) | | Cite: | Selective ligand recognition and activation of somatostatin receptors SSTR1 and SSTR3
To Be Published
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8XIR
 | | Structure of pasireotide-SSTR3 G protein complex | | Descriptor: | G-alpha i, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Wang, Y, Xu, Y, Xu, H.E, Zhuang, Y. | | Deposit date: | 2023-12-19 | | Release date: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (2.52 Å) | | Cite: | Selective ligand recognition and activation of somatostatin receptors SSTR1 and SSTR3
To Be Published
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6J4F
 | | Crystal structure of the AtWRKY2 domain | | Descriptor: | DNA (5'-D(*AP*GP*CP*CP*TP*TP*TP*GP*AP*CP*CP*AP*GP*CP*G)-3'), DNA (5'-D(*TP*CP*GP*CP*TP*GP*GP*TP*CP*AP*AP*AP*GP*GP*C)-3'), Probable WRKY transcription factor 2, ... | | Authors: | Xu, Y.P, Xu, H, Wang, B, Su, X.D. | | Deposit date: | 2019-01-08 | | Release date: | 2020-01-15 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structure of the AtWRKY2 domain
To Be Published
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5TO6
 | | Structure of the TPR oligomerization domain | | Descriptor: | Nucleoprotein TPR | | Authors: | Pal, K, Bandyopadhyay, A, Xu, Q, Zhou, X.E, Melcher, K, Xu, H.E. | | Deposit date: | 2016-10-16 | | Release date: | 2017-10-18 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural Basis of TPR-Mediated Oligomerization and Activation of Oncogenic Fusion Kinases.
Structure, 25, 2017
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5TO7
 | | Structure of the TPR oligomerization domain | | Descriptor: | Nucleoprotein TPR | | Authors: | Pal, K, Xu, Q, Zhou, X.E, Melcher, K, Xu, H.E. | | Deposit date: | 2016-10-16 | | Release date: | 2017-10-18 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural Basis of TPR-Mediated Oligomerization and Activation of Oncogenic Fusion Kinases.
Structure, 25, 2017
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3KAZ
 | | Crystal structure of abscisic acid receptor PYL2 | | Descriptor: | 1,3-BUTANEDIOL, Putative uncharacterized protein At2g26040 | | Authors: | Zhou, X.E, Melcher, K, Ng, L.-M, Soon, F.-F, Xu, Y, Suino-Powell, K.M, Kovach, A, Li, J, Xu, H.E. | | Deposit date: | 2009-10-19 | | Release date: | 2009-12-08 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Agate-latch-lock mechanism for hormone signalling by abscisic acid receptors
Nature, 462, 2009
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3KB3
 | | Crystal structure of abscisic acid-bound PYL2 in complex with HAB1 | | Descriptor: | (2Z,4E)-5-[(1S)-1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl]-3-methylpenta-2,4-dienoic acid, MAGNESIUM ION, Protein phosphatase 2C 16, ... | | Authors: | Zhou, X.E, Melcher, K, Soon, F.-F, Ng, L.-M, Xu, Y, Suino-Powell, K.M, Kovach, A, Li, J, Xu, H.E. | | Deposit date: | 2009-10-20 | | Release date: | 2009-12-08 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Agate-latch-lock mechanism for hormone signalling by abscisic acid receptors
Nature, 462, 2009
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1GCB
 | | GAL6, YEAST BLEOMYCIN HYDROLASE DNA-BINDING PROTEASE (THIOL) | | Descriptor: | GAL6 HG (EMTS) DERIVATIVE, GLYCEROL, MERCURY (II) ION, ... | | Authors: | Joshua-Tor, L, Xu, H.E, Johnston, S.A, Rees, D.C. | | Deposit date: | 1995-07-18 | | Release date: | 1995-10-15 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of a conserved protease that binds DNA: the bleomycin hydrolase, Gal6.
Science, 269, 1995
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8WZ2
 | | Structure of 26RFa-pyroglutamylated RFamide peptide receptor complex | | Descriptor: | G-alpha q, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Jin, S, Li, X, Xu, Y, Guo, S, Wu, C, Zhang, H, Yuan, Q, Xu, H.E, Xie, X, Jiang, Y. | | Deposit date: | 2023-11-01 | | Release date: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (2.73 Å) | | Cite: | Structural basis for recognition of 26RFa by the pyroglutamylated RFamide peptide receptor.
Cell Discov, 10, 2024
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8F7X
 | | Gi bound nociceptin receptor in complex with nociceptin peptide | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | Authors: | Wang, Y, Zhuang, Y, DiBerto, J.F, Zhou, X.E, Schmitz, G.P, Yuan, Q, Jain, M.K, Liu, W, Melcher, K, Jiang, Y, Roth, B.L, Xu, H.E. | | Deposit date: | 2022-11-20 | | Release date: | 2022-12-14 | | Last modified: | 2023-02-01 | | Method: | ELECTRON MICROSCOPY (3.28 Å) | | Cite: | Structures of the entire human opioid receptor family.
Cell, 186, 2023
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6PB0
 | | Cryo-EM structure of Urocortin 1-bound Corticotropin-releasing factor 1 receptor in complex with Gs protein and Nb35 | | Descriptor: | CHOLESTEROL, Corticotropin-releasing factor receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Ma, S, Shen, Q, Zhao, L.-H, Mao, C, Zhou, X.E, Shen, D.-D, de Waal, P.W, Bi, P, Li, C, Jiang, Y, Wang, M.-W, Sexton, P.M, Wootten, D, Melcher, K, Zhang, Y, Xu, H.E. | | Deposit date: | 2019-06-12 | | Release date: | 2020-02-12 | | Last modified: | 2020-02-19 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors.
Mol.Cell, 77, 2020
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6PB1
 | | Cryo-EM structure of Urocortin 1-bound Corticotropin-releasing factor 2 receptor in complex with Gs protein and Nb35 | | Descriptor: | CHOLESTEROL, Corticotropin-releasing factor receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Ma, S, Shen, Q, Zhao, L.-H, Mao, C, Zhou, X.E, Shen, D.-D, de Waal, P.W, Bi, P, Li, C, Jiang, Y, Wang, M.-W, Sexton, P.M, Wootten, D, Melcher, K, Zhang, Y, Xu, H.E. | | Deposit date: | 2019-06-12 | | Release date: | 2020-02-12 | | Last modified: | 2020-02-19 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors.
Mol.Cell, 77, 2020
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5DGY
 | | Crystal structure of rhodopsin bound to visual arrestin | | Descriptor: | Endolysin,Rhodopsin,S-arrestin | | Authors: | Zhou, X.E, Gao, X, Kang, Y, He, Y, de Waal, P.W, Suino-Powell, K.M, Wang, M, Melcher, K, Xu, H.E. | | Deposit date: | 2015-08-28 | | Release date: | 2016-03-23 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (7.7 Å) | | Cite: | X-ray laser diffraction for structure determination of the rhodopsin-arrestin complex.
Sci Data, 3, 2016
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5UWG
 | | The crystal structure of Fz4-CRD in complex with palmitoleic acid | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Frizzled-4, PALMITOLEIC ACID | | Authors: | Ke, J, DeBruine, Z.J, Gu, X, Brunzelle, J.S, Xu, H.E, Melcher, K. | | Deposit date: | 2017-02-21 | | Release date: | 2017-06-14 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.56 Å) | | Cite: | Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization.
Genes Dev., 31, 2017
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5CL1
 | | Complex structure of Norrin with human Frizzled 4 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Frizzled-4, Maltose-binding periplasmic protein,Norrin | | Authors: | Wang, Z, Ke, J, Shen, G, Cheng, Z, Xu, H.E, Xu, W. | | Deposit date: | 2015-07-16 | | Release date: | 2015-08-12 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3.8 Å) | | Cite: | Structural basis of the Norrin-Frizzled 4 interaction.
Cell Res., 25, 2015
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8YKW
 | | Cryo-EM structure of succinate receptor SUCR1 bound to succinic acid | | Descriptor: | Antibody fragment ScFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Li, C, Liu, H, Li, J, Zhu, H, Fu, W, Xu, H.E. | | Deposit date: | 2024-03-05 | | Release date: | 2024-05-29 | | Last modified: | 2024-08-14 | | Method: | ELECTRON MICROSCOPY (2.75 Å) | | Cite: | Molecular basis of ligand recognition and activation of the human succinate receptor SUCR1.
Cell Res., 34, 2024
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8YKV
 | | Cryo-EM structure of succinate receptor SUCR1 bound to compound 31 | | Descriptor: | (2~{S})-2-[[6-[4-(trifluoromethyloxy)phenyl]pyridin-2-yl]carbonylamino]butanedioic acid, Antibody fragment ScFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Li, C, Liu, H, Li, J, Zhu, H, Fu, W, Xu, H.E. | | Deposit date: | 2024-03-05 | | Release date: | 2024-05-29 | | Last modified: | 2024-08-14 | | Method: | ELECTRON MICROSCOPY (2.48 Å) | | Cite: | Molecular basis of ligand recognition and activation of the human succinate receptor SUCR1.
Cell Res., 34, 2024
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8YKX
 | | Cryo-EM structure of succinate receptor SUCR1 bound to maleic acid | | Descriptor: | Antibody fragment ScFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Li, C, Liu, H, Li, J, Zhu, H, Fu, W, Xu, H.E. | | Deposit date: | 2024-03-05 | | Release date: | 2024-05-29 | | Last modified: | 2024-08-14 | | Method: | ELECTRON MICROSCOPY (2.69 Å) | | Cite: | Molecular basis of ligand recognition and activation of the human succinate receptor SUCR1.
Cell Res., 34, 2024
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1FM6
 | | THE 2.1 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE HETERODIMER OF THE HUMAN RXRALPHA AND PPARGAMMA LIGAND BINDING DOMAINS RESPECTIVELY BOUND WITH 9-CIS RETINOIC ACID AND ROSIGLITAZONE AND CO-ACTIVATOR PEPTIDES. | | Descriptor: | (9cis)-retinoic acid, 2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL), ... | | Authors: | Gampe Jr, R.T, Montana, V.G, Lambert, M.H, Miller, A.B, Bledsoe, R.K, Milburn, M.V, Kliewer, S.A, Willson, T.M, Xu, H.E. | | Deposit date: | 2000-08-16 | | Release date: | 2001-02-16 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors.
Mol.Cell, 5, 2000
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