5TO6

Structure of the TPR oligomerization domain

Summary for 5TO6

Related5TO5 5TO7
DescriptorNucleoprotein TPR (2 entities in total)
Functional Keywordstpr oligomerization domain, receptor tyrosine kinase, met, oncogenic fusion kinases, cell cycle
Biological sourceHomo sapiens (Human)
Total number of polymer chains4
Total molecular weight67119.51
Authors
Pal, K.,Bandyopadhyay, A.,Xu, Q.,Zhou, X.E.,Melcher, K.,Xu, H.E. (deposition date: 2016-10-16, release date: 2017-10-18, Last modification date: 2019-05-01)
Primary citation
Pal, K.,Bandyopadhyay, A.,Zhou, X.E.,Xu, Q.,Marciano, D.P.,Brunzelle, J.S.,Yerrum, S.,Griffin, P.R.,Vande Woude, G.,Melcher, K.,Xu, H.E.
Structural Basis of TPR-Mediated Oligomerization and Activation of Oncogenic Fusion Kinases.
Structure, 25:867-877.e3, 2017
PubMed: 28528776 (PDB entries with the same primary citation)
DOI: 10.1016/j.str.2017.04.015
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.7 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.29220 0.2% 2.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution