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PDB: 404 results

3OXI
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Design and Synthesis of Disubstituted Thiophene and Thiazole Based Inhibitors of JNK for the Treatment of Neurodegenerative Diseases
Descriptor: Mitogen-activated protein kinase 10, Mitogen-activated protein kinase 8 interacting protein 1, methyl 3-[(thiophen-2-ylacetyl)amino]thiophene-2-carboxylate
Authors:Hom, R.K, Bowers, S, Sealy, J, Truong, A, Probst, G.D, Neitzel, M, Neitz, J, Fang, L, Brogley, L, Wu, J, Konradi, A.W, Sham, H, Toth, G, Pan, H, Yao, N, Artis, D.R.
Deposit date:2010-09-21
Release date:2011-05-04
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK.
Bioorg.Med.Chem.Lett., 20, 2010
3OXF
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BU of 3oxf by Molmil
Human lysine methyltransferase Smyd3 in complex with AdoHcy (Form I)
Descriptor: S-ADENOSYL-L-HOMOCYSTEINE, SET and MYND domain-containing protein 3, ZINC ION
Authors:Xu, S, Wu, J, Sun, B, Zhong, C, Ding, J.
Deposit date:2010-09-21
Release date:2011-02-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:Structural and biochemical studies of human lysine methyltransferase Smyd3 reveal the important functional roles of its post-SET and TPR domains and the regulation of its activity by DNA binding.
Nucleic Acids Res., 39, 2011
4FZ3
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BU of 4fz3 by Molmil
Crystal structure of SIRT3 in complex with acetyl p53 peptide coupled with 4-amino-7-methylcoumarin
Descriptor: NAD-dependent protein deacetylase sirtuin-3, mitochondrial, ZINC ION, ...
Authors:Liu, D, Wu, J, Zhang, D, Chen, K, Jiang, H, Liu, H.
Deposit date:2012-07-06
Release date:2013-03-20
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery and Mechanism Study of SIRT1 Activators that Promote the Deacetylation of Fluorophore-Labeled Substrate
J.Med.Chem., 56, 2013
1TMW
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BU of 1tmw by Molmil
Solution structure of Human Coactosin Like Protein D123N
Descriptor: Coactosin-like protein
Authors:Dai, H, Wu, J, Xu, Y, Tang, Y, Ding, H, Shi, Y.
Deposit date:2004-06-11
Release date:2005-06-28
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Study on Solution Structure and Its binding function to F-actin
To be Published
1U4A
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BU of 1u4a by Molmil
Solution structure of human SUMO-3 C47S
Descriptor: Ubiquitin-like protein SMT3A
Authors:Ding, H, Xu, Y, Dai, H, Tang, Y, Wu, J, Shi, Y.
Deposit date:2004-07-23
Release date:2005-03-08
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Solution Structure of Human SUMO-3 C47S and Its Binding Surface for Ubc9
Biochemistry, 44, 2005
1RZM
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BU of 1rzm by Molmil
Crystal structure of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (DAHPS) from Thermotoga maritima complexed with Cd2+, PEP and E4P
Descriptor: CADMIUM ION, ERYTHOSE-4-PHOSPHATE, PHOSPHOENOLPYRUVATE, ...
Authors:Shumilin, I.A, Bauerle, R, Wu, J, Woodard, R.W, Kretsinger, R.H.
Deposit date:2003-12-24
Release date:2004-08-10
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of the Reaction Complex of 3-Deoxy-d-arabino-heptulosonate-7-phosphate Synthase from Thermotoga maritima Refines the Catalytic Mechanism and Indicates a New Mechanism of Allosteric Regulation.
J.Mol.Biol., 341, 2004
4ZOU
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BU of 4zou by Molmil
Crystal structure of the BTB domain of SLX4
Descriptor: Structure-specific endonuclease subunit SLX4
Authors:Wan, B, Chen, Y, Wu, J, Liu, Y, Lei, M.
Deposit date:2015-05-07
Release date:2016-05-04
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The BTB domain is both a structural and functional pivot of the SLX4-nuclease complex
to be published
1RJI
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BU of 1rji by Molmil
Solution Structure of BmKX, a novel potassium channel blocker from the Chinese Scorpion Buthus martensi Karsch
Descriptor: potassium channel toxin KX
Authors:Cai, Z, Wu, J, Xu, Y, Wang, C.-G, Chi, C.-W, Shi, Y.
Deposit date:2003-11-19
Release date:2003-12-09
Last modified:2024-10-23
Method:SOLUTION NMR
Cite:A novel short-chain peptide BmKX from the Chinese scorpion Buthus martensi karsch, sequencing, gene cloning and structure determination
Toxicon, 45, 2005
5FO7
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BU of 5fo7 by Molmil
Crystal Structure of Human Complement C3b at 2.8 Angstrom resolution
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN
Authors:Forneris, F, Wu, J, Xue, X, Gros, P.
Deposit date:2015-11-18
Release date:2016-04-06
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 35, 2016
5FO8
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BU of 5fo8 by Molmil
Crystal Structure of Human Complement C3b in Complex with MCP (CCP1-4)
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COMPLEMENT C3, ...
Authors:Forneris, F, Wu, J, Xue, X, Gros, P.
Deposit date:2015-11-18
Release date:2016-04-06
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 35, 2016
7V99
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BU of 7v99 by Molmil
catalytic core of human telomerase holoenzyme
Descriptor: Histone H2A type 1-B/E, Histone H2B type 1-K, Primer DNA, ...
Authors:Wan, F, Ding, Y, Yang, L, Wu, Z, Wu, J, Lei, M.
Deposit date:2021-08-24
Release date:2022-03-30
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (3.54 Å)
Cite:Zipper head mechanism of telomere synthesis by human telomerase.
Cell Res., 31, 2021
5FO9
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BU of 5fo9 by Molmil
Crystal Structure of Human Complement C3b in Complex with CR1 (CCP15- 17)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN, ...
Authors:Forneris, F, Wu, J, Xue, X, Gros, P.
Deposit date:2015-11-18
Release date:2016-04-06
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 35, 2016
3OXL
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BU of 3oxl by Molmil
Human lysine methyltransferase Smyd3 in complex with AdoHcy (Form II)
Descriptor: S-ADENOSYL-L-HOMOCYSTEINE, SET and MYND domain-containing protein 3, ZINC ION
Authors:Xu, S, Wu, J, Sun, B, Zhong, C, Ding, J.
Deposit date:2010-09-21
Release date:2011-02-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structural and biochemical studies of human lysine methyltransferase Smyd3 reveal the important functional roles of its post-SET and TPR domains and the regulation of its activity by DNA binding
Nucleic Acids Res., 39, 2011
7V9A
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BU of 7v9a by Molmil
biogenesis module of human telomerase holoenzyme
Descriptor: H/ACA ribonucleoprotein complex subunit 1, H/ACA ribonucleoprotein complex subunit 2, H/ACA ribonucleoprotein complex subunit 3, ...
Authors:Wan, F, Ding, Y, Yang, L, Wu, Z, Wu, J, Lei, M.
Deposit date:2021-08-24
Release date:2022-03-30
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.94 Å)
Cite:Zipper head mechanism of telomere synthesis by human telomerase.
Cell Res., 31, 2021
7V2Y
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BU of 7v2y by Molmil
cryo-EM structure of yeast THO complex with Sub2
Descriptor: ATP-dependent RNA helicase SUB2, Protein TEX1, THO complex subunit 2, ...
Authors:Chen, C, Tan, M, Wu, Z, Wu, J, Lei, M.
Deposit date:2021-08-10
Release date:2022-07-27
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural and functional insights into R-loop prevention and mRNA export by budding yeast THO-Sub2 complex.
Sci Bull (Beijing), 66, 2021
7V2W
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BU of 7v2w by Molmil
protomer structure from the dimer of yeast THO complex
Descriptor: Protein TEX1, THO complex subunit 2, THO complex subunit HPR1, ...
Authors:Chen, C, Tan, M, Wu, Z, Wu, J, Lei, M.
Deposit date:2021-08-10
Release date:2022-07-27
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural and functional insights into R-loop prevention and mRNA export by budding yeast THO-Sub2 complex.
Sci Bull (Beijing), 66, 2021
6BYM
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BU of 6bym by Molmil
Crystal structure of the sterol-bound second StART domain of yeast Lam4
Descriptor: 25-HYDROXYCHOLESTEROL, Sterol-binding protein
Authors:Jentsch, J.A, Kiburu, I.N, Wu, J, Pandey, K, Boudker, O, Menon, A.K.
Deposit date:2017-12-20
Release date:2018-01-17
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis of sterol binding and transport by a yeast StARkin domain.
J. Biol. Chem., 293, 2018
4OV9
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BU of 4ov9 by Molmil
Structure of isopropylmalate synthase binding with alpha-isopropylmalate
Descriptor: (2S)-2-hydroxy-2-(propan-2-yl)butanedioic acid, ZINC ION, isopropylmalate synthase
Authors:Zhang, Z, Wu, J, Wang, C, Zhang, P.
Deposit date:2014-02-20
Release date:2014-08-20
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Subdomain II of alpha-isopropylmalate synthase is essential for activity: inferring a mechanism of feedback inhibition.
J.Biol.Chem., 289, 2014
5TVC
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BU of 5tvc by Molmil
Crystal structure of a chimeric acetylcholine binding protein from Aplysia californica (Ac-AChBP) containing loop C from the human alpha 3 nicotinic acetylcholine receptor in complex with (E,2S)-N-methyl-5-(5-phenoxy-3-pyridyl)pent-4-en-2-amine (TI-5312)
Descriptor: (E,2S)-N-methyl-5-(5-phenoxy-3-pyridyl)pent-4-en-2-amine, PENTAETHYLENE GLYCOL, SULFATE ION, ...
Authors:Bobango, J, Wu, J, Talley, I.T, Talley, T.T.
Deposit date:2016-11-08
Release date:2016-11-30
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.926 Å)
Cite:Crystal structure of a chimeric acetylcholine binding protein from Aplysia californica (Ac-AChBP) containing loop C from the human alpha 3 nicotinic acetylcholine receptor in complex with (E,2S)-N-methyl-5-(5-phenoxy-3-pyridyl)pent-4-en-2-amine (TI-5312)
To Be Published
1PSW
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BU of 1psw by Molmil
Structure of E. coli ADP-heptose lps heptosyltransferase II
Descriptor: ADP-HEPTOSE LPS HEPTOSYLTRANSFERASE II
Authors:Kniewel, R, Buglino, J, Solorzano, V, Wu, J, Lima, C.D, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2003-06-21
Release date:2003-07-08
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of E. coli ADP-heptose lps heptosyltransferase II
To be Published
1RI6
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BU of 1ri6 by Molmil
Structure of a putative isomerase from E. coli
Descriptor: putative isomerase ybhE
Authors:Lima, C.D, Kniewel, R, Solorzano, V, Wu, J, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2003-11-16
Release date:2003-11-25
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of a putative 7-bladed propeller isomerase
To be Published
6BYD
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BU of 6byd by Molmil
Crystal structure of the second StART domain of yeast Lam4
Descriptor: Membrane-anchored lipid-binding protein LAM4
Authors:Jentsch, J.A, Kiburu, I.N, Wu, J, Pandey, K, Boudker, O, Menon, A.K.
Deposit date:2017-12-20
Release date:2018-01-31
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.195 Å)
Cite:Structural basis of sterol binding and transport by a yeast StARkin domain.
J. Biol. Chem., 293, 2018
5FOB
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BU of 5fob by Molmil
Crystal Structure of Human Complement C3b in complex with Smallpox Inhibitor of Complement (SPICE)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, COMPLEMENT C3 BETA CHAIN, ...
Authors:Forneris, F, Wu, J, Xue, X, Gros, P.
Deposit date:2015-11-18
Release date:2016-04-06
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 35, 2016
7X5C
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BU of 7x5c by Molmil
Solution structure of Tetrahymena p75OB1-p50PBM
Descriptor: Telomerase associated protein p50PBM, Telomerase-associated protein p75OB1
Authors:Wu, B, Tang, T, Xue, H.J, Wu, J, Lei, M.
Deposit date:2022-03-04
Release date:2022-10-19
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Association of the CST complex and p50 in Tetrahymena is crucial for telomere maintenance
Structure, 2022
1SJ6
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BU of 1sj6 by Molmil
NMR Structure and Regulated Expression in APL Cell of Human SH3BGRL3
Descriptor: SH3 domain-binding glutamic acid-rich-like protein 3
Authors:Xu, C, Tang, Y, Xu, Y, Wu, J, Shi, Y, Zhang, Q, Zheng, P, Du, Y.
Deposit date:2004-03-03
Release date:2005-03-22
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:NMR structure and regulated expression in APL cell of human SH3BGRL3.
Febs Lett., 579, 2005

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