4FZ3
Crystal structure of SIRT3 in complex with acetyl p53 peptide coupled with 4-amino-7-methylcoumarin
Summary for 4FZ3
Entry DOI | 10.2210/pdb4fz3/pdb |
Descriptor | NAD-dependent protein deacetylase sirtuin-3, mitochondrial, peptide from Cellular tumor antigen p53, ZINC ION, ... (4 entities in total) |
Functional Keywords | zinc-binding motif, rossmann fold, nad-dependent deacetylase, mitochondrial, hydrolase-hydrolase substrate complex, hydrolase/hydrolase substrate |
Biological source | Homo sapiens (human) More |
Cellular location | Mitochondrion matrix: Q9NTG7 Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637 |
Total number of polymer chains | 2 |
Total formula weight | 32258.50 |
Authors | |
Primary citation | Wu, J.,Zhang, D.,Chen, L.,Li, J.,Wang, J.,Ning, C.,Yu, N.,Zhao, F.,Chen, D.,Chen, X.,Chen, K.,Jiang, H.,Liu, H.,Liu, D. Discovery and Mechanism Study of SIRT1 Activators that Promote the Deacetylation of Fluorophore-Labeled Substrate J.Med.Chem., 56:761-780, 2013 Cited by PubMed: 23316803DOI: 10.1021/jm301032j PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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