4PSQ
 
 | | Crystal Structure of Retinol-Binding Protein 4 (RBP4) in complex with a non-retinoid ligand | | 分子名称: | (1-benzyl-1H-imidazol-4-yl)[4-(2-chlorophenyl)piperazin-1-yl]methanone, 1,2-ETHANEDIOL, PHOSPHATE ION, ... | | 著者 | Wang, Z, Johnstone, S, Walker, N. | | 登録日 | 2014-03-07 | | 公開日 | 2014-07-02 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structure-assisted discovery of the first non-retinoid ligands for Retinol-Binding Protein 4.
Bioorg.Med.Chem.Lett., 24, 2014
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4JOL
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3LPY
 | | Crystal structure of the RRM domain of CyP33 | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Peptidyl-prolyl cis-trans isomerase E, SULFATE ION | | 著者 | Wang, Z, Patel, D.J. | | 登録日 | 2010-02-07 | | 公開日 | 2010-07-07 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression.
Cell(Cambridge,Mass.), 141, 2010
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3LQH
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3LQJ
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3LQI
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1A4L
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1A4M
 | | ADA STRUCTURE COMPLEXED WITH PURINE RIBOSIDE AT PH 7.0 | | 分子名称: | 6-HYDROXY-1,6-DIHYDRO PURINE NUCLEOSIDE, ADENOSINE DEAMINASE, ZINC ION | | 著者 | Wang, Z, Quiocho, F.A. | | 登録日 | 1998-01-31 | | 公開日 | 1998-10-14 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Complexes of adenosine deaminase with two potent inhibitors: X-ray structures in four independent molecules at pH of maximum activity.
Biochemistry, 37, 1998
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1PBP
 | | FINE TUNING OF THE SPECIFICITY OF THE PERIPLASMIC PHOSPHATE TRANSPORT RECEPTOR: SITE-DIRECTED MUTAGENESIS, LIGAND BINDING, AND CRYSTALLOGRAPHIC STUDIES | | 分子名称: | PHOSPHATE ION, PHOSPHATE-BINDING PROTEIN | | 著者 | Wang, Z, Choudhary, A, Ledvina, P.S, Quiocho, F.A. | | 登録日 | 1994-07-20 | | 公開日 | 1994-10-15 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Fine tuning the specificity of the periplasmic phosphate transport receptor. Site-directed mutagenesis, ligand binding, and crystallographic studies.
J.Biol.Chem., 269, 1994
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3FUR
 | | Crystal Structure of PPARg in complex with INT131 | | 分子名称: | 2,4-dichloro-N-[3,5-dichloro-4-(quinolin-3-yloxy)phenyl]benzenesulfonamide, CHLORIDE ION, Nuclear receptor coactivator 1, ... | | 著者 | Wang, Z, Liu, J, Walker, N. | | 登録日 | 2009-01-14 | | 公開日 | 2009-06-09 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | INT131: a selective modulator of PPAR gamma.
J.Mol.Biol., 386, 2009
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4QC2
 | | Crystal structure of lipopolysaccharide transport protein LptB in complex with ATP and Magnesium ions | | 分子名称: | ABC transporter related protein, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION | | 著者 | Wang, Z, Xiang, Q, Zhu, X, Dong, H, He, C, Wang, H, Zhang, Y, Wang, W, Dong, C. | | 登録日 | 2014-05-09 | | 公開日 | 2014-10-22 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | | 主引用文献 | Structural and functional studies of conserved nucleotide-binding protein LptB in lipopolysaccharide transport.
Biochem.Biophys.Res.Commun., 452, 2014
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1OVL
 | | Crystal Structure of Nurr1 LBD | | 分子名称: | BROMIDE ION, IODIDE ION, Orphan nuclear receptor NURR1 (MSE 414, ... | | 著者 | Wang, Z, Liu, J, Walker, N. | | 登録日 | 2003-03-26 | | 公開日 | 2003-06-03 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structure and Function of Nurr1 identifies a Class of Ligand-Independent Nuclear Receptors
Nature, 423, 2003
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8GT6
 | | human STING With agonist HB3089 | | 分子名称: | 1-[(2E)-4-{5-carbamoyl-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-7-[3-(morpholin-4-yl)propoxy]-1H-benzimidazol-1-yl}but-2-en-1-yl]-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-7-methyl-1H-furo[3,2-e]benzimidazole-5-carboxamide, Stimulator of interferon genes protein | | 著者 | Wang, Z, Yu, X. | | 登録日 | 2022-09-07 | | 公開日 | 2022-12-28 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.47 Å) | | 主引用文献 | Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation.
Cell Discov, 8, 2022
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8GSZ
 | | Structure of STING SAVI-related mutant V147L | | 分子名称: | Stimulator of interferon genes protein | | 著者 | Wang, Z, Yu, X. | | 登録日 | 2022-09-07 | | 公開日 | 2022-12-28 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.65 Å) | | 主引用文献 | Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation.
Cell Discov, 8, 2022
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5NG5
 | | multi-drug efflux; membrane transport; RND superfamily; Drug resistance | | 分子名称: | 6-[2-(3,4-dimethoxyphenyl)ethylsulfanyl]-8-[4-(2-methoxyethyl)piperazin-1-yl]-3,3-dimethyl-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile, Multidrug efflux pump accessory protein AcrZ, Multidrug efflux pump subunit AcrA, ... | | 著者 | Wang, Z, Fan, G, Hryc, C.F, Blaza, J.N, Serysheva, I.I, Schmid, M.F, Chiu, W, Luisi, B.F, Du, D. | | 登録日 | 2017-03-16 | | 公開日 | 2017-04-19 | | 最終更新日 | 2017-08-02 | | 実験手法 | ELECTRON MICROSCOPY (6.5 Å) | | 主引用文献 | An allosteric transport mechanism for the AcrAB-TolC Multidrug Efflux Pump.
Elife, 6, 2017
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6P6J
 | | Structure of YbtPQ importer with substrate Ybt-Fe bound | | 分子名称: | ABC transporter protein, FE (III) ION, inner membrane ABC-transporter, ... | | 著者 | Wang, Z, Hu, W, Zheng, H. | | 登録日 | 2019-06-04 | | 公開日 | 2020-03-04 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Pathogenic siderophore ABC importer YbtPQ adopts a surprising fold of exporter.
Sci Adv, 6, 2020
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1ZW8
 | | Solution structure of a ZAP1 zinc-responsive domain provides insights into metalloregulatory transcriptional repression in Saccharomyces cerevisiae | | 分子名称: | ZINC ION, Zinc-responsive transcriptional regulator ZAP1 | | 著者 | Wang, Z, Feng, L.S, Venkataraman, K, Matskevich, V.A, Parasuram, P, Laity, J.H. | | 登録日 | 2005-06-03 | | 公開日 | 2006-01-10 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of a Zap1 zinc-responsive domain provides insights into metalloregulatory transcriptional repression in Saccharomyces cerevisiae.
J.Mol.Biol., 357, 2006
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3FCO
 | | Crystal Structure of 11beta-Hydroxysteroid Dehydrogenase 1 (11b-HSD1) in Complex with Benzamide Inhibitor | | 分子名称: | Corticosteroid 11-beta-dehydrogenase isozyme 1, N-cyclopropyl-N-(cis-4-cyclopropyl-4-hydroxycyclohexyl)-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Wang, Z, Sudom, A, Walker, N.P. | | 登録日 | 2008-11-21 | | 公開日 | 2009-12-01 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Optimization of novel di-substituted cyclohexylbenzamide derivatives as potent 11 beta-HSD1 inhibitors.
Bioorg.Med.Chem.Lett., 19, 2009
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6EF4
 | | Crystal structure of mouse PP2A Aalpha P179R mutant | | 分子名称: | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform | | 著者 | Wang, Z, Shen, G, Xu, W. | | 登録日 | 2018-08-16 | | 公開日 | 2019-06-26 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | The Highly Recurrent PP2A A alpha-Subunit Mutation P179R Alters Protein Structure and Impairs PP2A Enzyme Function to Promote Endometrial Tumorigenesis.
Cancer Res., 79, 2019
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5HKP
 | | Crystal structure of mouse Tankyrase/human TRF1 complex | | 分子名称: | Tankyrase-1, Telomeric repeat-binding factor 1 | | 著者 | Wang, Z, Li, B, Rao, Z, Xu, W. | | 登録日 | 2016-01-14 | | 公開日 | 2016-03-23 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structure of a tankyrase 1-telomere repeat factor 1 complex.
Acta Crystallogr F Struct Biol Commun, 72, 2016
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3FRJ
 | | Crystal Structure of 11b-Hydroxysteroid Dehydrogenase-1 (11b-HSD1) in Complex with Piperidyl Benzamide Inhibitor | | 分子名称: | Corticosteroid 11-beta-Dehydrogenase, Isozyme 1, N-{1-[(1-carbamoylcyclopropyl)methyl]piperidin-4-yl}-N-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide, ... | | 著者 | Wang, Z, Sudom, A, Walker, N.P. | | 登録日 | 2009-01-08 | | 公開日 | 2009-06-16 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Discovery and optimization of piperidyl benzamide derivatives as a novel class of 11beta-HSD1 inhibitors.
Bioorg.Med.Chem.Lett., 19, 2009
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3GZ9
 | | Crystal Structure of Peroxisome Proliferator-Activated Receptor Delta (PPARd) in Complex with a Full Agonist | | 分子名称: | (2,3-dimethyl-4-{[2-(prop-2-yn-1-yloxy)-4-{[4-(trifluoromethyl)phenoxy]methyl}phenyl]sulfanyl}phenoxy)acetic acid, Peroxisome proliferator-activated receptor delta, heptyl beta-D-glucopyranoside | | 著者 | Wang, Z, Sudom, A, Walker, N.P. | | 登録日 | 2009-04-06 | | 公開日 | 2009-06-30 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Identification of a PPARdelta agonist with partial agonistic activity on PPARgamma.
Bioorg.Med.Chem.Lett., 19, 2009
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5CL1
 | | Complex structure of Norrin with human Frizzled 4 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Frizzled-4, Maltose-binding periplasmic protein,Norrin | | 著者 | Wang, Z, Ke, J, Shen, G, Cheng, Z, Xu, H.E, Xu, W. | | 登録日 | 2015-07-16 | | 公開日 | 2015-08-12 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | | 主引用文献 | Structural basis of the Norrin-Frizzled 4 interaction.
Cell Res., 25, 2015
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3H0A
 | | Crystal Structure of Peroxisome Proliferator-Activated Receptor Gamma (PPARg) and Retinoic Acid Receptor Alpha (RXRa) in Complex with 9-cis Retinoic Acid, Co-activator Peptide, and a Partial Agonist | | 分子名称: | 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethenyl]benzoic acid, Nuclear receptor coactivator 1, Co-activator Peptide, ... | | 著者 | Wang, Z, Sudom, A, Walker, N.P. | | 登録日 | 2009-04-08 | | 公開日 | 2009-06-09 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Identification of a PPARdelta agonist with partial agonistic activity on PPARgamma.
Bioorg.Med.Chem.Lett., 19, 2009
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3J7N
 | | Virus model of brome mosaic virus (second half data set) | | 分子名称: | Capsid protein | | 著者 | Wang, Z, Hryc, C, Bammes, B, Afonine, P.V, Jakana, J, Chen, D.H, Liu, X, Baker, M.L, Kao, C, Ludtke, S.J, Schmid, M.F, Adams, P.D, Chiu, W. | | 登録日 | 2014-07-18 | | 公開日 | 2014-09-10 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | An atomic model of brome mosaic virus using direct electron detection and real-space optimization.
Nat Commun, 5, 2014
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