3FRJ

Crystal Structure of 11b-Hydroxysteroid Dehydrogenase-1 (11b-HSD1) in Complex with Piperidyl Benzamide Inhibitor

Summary for 3FRJ

• Entry DOI: 10.2210/pdb3frj/pdb
• Descriptor: Corticosteroid 11-beta-Dehydrogenase, Isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-{1-[(1-carbamoylcyclopropyl)methyl]piperidin-4-yl}-N-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide, ... (4 entities in total)
• Functional Keywords: oxidoreductase, endoplasmic reticulum, glycoprotein, lipid metabolism, membrane, nadp, polymorphism, signal-anchor, steroid metabolism, transmembrane
• Biological source: Homo sapiens (human)
• Cellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein: P28845
• Total number of polymer chains: 2
• Total formula weight: 65614.06

Authors

Wang, Z.,Sudom, A.,Walker, N.P. (deposition date: 2009-01-08, release date: 2009-06-16, Last modification date: 2024-02-21)

• Primary citation: Rew, Y.,McMinn, D.L.,Wang, Z.,He, X.,Hungate, R.W.,Jaen, J.C.,Sudom, A.,Sun, D.,Tu, H.,Ursu, S.,Villemure, E.,Walker, N.P.,Yan, X.,Ye, Q.,Powers, J.P.; Discovery and optimization of piperidyl benzamide derivatives as a novel class of 11beta-HSD1 inhibitors.; Bioorg.Med.Chem.Lett., 19:1797-1801, 2009; PubMed: 19217779; DOI: 10.1016/j.bmcl.2009.01.058

Experimental method

X-RAY DIFFRACTION (2.3 Å)