3GZ9

Crystal Structure of Peroxisome Proliferator-Activated Receptor Delta (PPARd) in Complex with a Full Agonist

Summary for 3GZ9

Entry DOI	10.2210/pdb3gz9/pdb
Descriptor	Peroxisome proliferator-activated receptor delta, heptyl beta-D-glucopyranoside, (2,3-dimethyl-4-{[2-(prop-2-yn-1-yloxy)-4-{[4-(trifluoromethyl)phenoxy]methyl}phenyl]sulfanyl}phenoxy)acetic acid, ... (4 entities in total)
Functional Keywords	ppar, ppar delta, transcription, nuclear receptor fold, transcription regulation, hormone, growth factor receptor, complex, activator, alternative splicing, dna-binding, metal-binding, nucleus, receptor, zinc, zinc-finger
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	31487.54
Authors	Wang, Z.,Sudom, A.,Walker, N.P. (deposition date: 2009-04-06, release date: 2009-06-30, Last modification date: 2024-02-21)
Primary citation	Connors, R.V.,Wang, Z.,Harrison, M.,Zhang, A.,Wanska, M.,Hiscock, S.,Fox, B.,Dore, M.,Labelle, M.,Sudom, A.,Johnstone, S.,Liu, J.,Walker, N.P.,Chai, A.,Siegler, K.,Li, Y.,Coward, P. Identification of a PPARdelta agonist with partial agonistic activity on PPARgamma. Bioorg.Med.Chem.Lett., 19:3550-3554, 2009 Cited by PubMed Abstract: The discovery and optimization of a series of potent PPARdelta full agonists with partial agonistic activity against PPARgamma is described. PubMed: 19464171 DOI: 10.1016/j.bmcl.2009.04.151 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation