3GZ9
Crystal Structure of Peroxisome Proliferator-Activated Receptor Delta (PPARd) in Complex with a Full Agonist
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Peroxisome proliferator-activated receptor delta | polymer | 269 | 30692.7 | 1 | UniProt (Q03181) Pfam (PF00104) In PDB | Homo sapiens (human) | PPAR-delta, PPAR-beta, Nuclear receptor subfamily 1 group C member 2, Nuclear hormone receptor 1, NUC1, NUCI |
| 2 | A | heptyl beta-D-glucopyranoside | non-polymer | 278.3 | 1 | Chemie (B7G) | |||
| 3 | A | (2,3-dimethyl-4-{[2-(prop-2-yn-1-yloxy)-4-{[4-(trifluoromethyl)phenoxy]methyl}phenyl]sulfanyl}phenoxy)acetic acid | non-polymer | 516.5 | 1 | Chemie (D32) | |||
| 4 | water | water | 18.0 | 172 | Chemie (HOH) |
Sequence modifications
A: 207 - 475 (UniProt: Q03181)
| PDB | External Database | Details |
|---|---|---|
| Gly 307 | Ser 271 | engineered mutation |
| Leu 333 | Ile 297 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 30692.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 794.9 | |
| All* | Total formula weight | 31487.5 |
