6EF4

Crystal structure of mouse PP2A Aalpha P179R mutant

Summary for 6EF4

Entry DOI	10.2210/pdb6ef4/pdb
Descriptor	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (1 entity in total)
Functional Keywords	pp2a, aalpha, protein binding
Biological source	Mus musculus (Mouse)
Total number of polymer chains	1
Total formula weight	65509.50
Authors	Wang, Z.,Shen, G.,Xu, W. (deposition date: 2018-08-16, release date: 2019-06-26, Last modification date: 2023-10-11)
Primary citation	Taylor, S.E.,O'Connor, C.M.,Wang, Z.,Shen, G.,Song, H.,Leonard, D.,Sangodkar, J.,LaVasseur, C.,Avril, S.,Waggoner, S.,Zanotti, K.,Armstrong, A.J.,Nagel, C.,Resnick, K.,Singh, S.,Jackson, M.W.,Xu, W.,Haider, S.,DiFeo, A.,Narla, G. The Highly Recurrent PP2A A alpha-Subunit Mutation P179R Alters Protein Structure and Impairs PP2A Enzyme Function to Promote Endometrial Tumorigenesis. Cancer Res., 79:4242-4257, 2019 Cited by PubMed: 31142515 DOI: 10.1158/0008-5472.CAN-19-0218 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.4 Å)

Structure validation