6EF4
Crystal structure of mouse PP2A Aalpha P179R mutant
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000159 | cellular_component | protein phosphatase type 2A complex |
| A | 0000775 | cellular_component | chromosome, centromeric region |
| A | 0000785 | cellular_component | chromatin |
| A | 0004722 | molecular_function | protein serine/threonine phosphatase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005694 | cellular_component | chromosome |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006366 | biological_process | transcription by RNA polymerase II |
| A | 0006368 | biological_process | transcription elongation by RNA polymerase II |
| A | 0007059 | biological_process | chromosome segregation |
| A | 0007143 | biological_process | female meiotic nuclear division |
| A | 0016328 | cellular_component | lateral plasma membrane |
| A | 0019888 | molecular_function | protein phosphatase regulator activity |
| A | 0030425 | cellular_component | dendrite |
| A | 0032039 | cellular_component | integrator complex |
| A | 0034243 | biological_process | regulation of transcription elongation by RNA polymerase II |
| A | 0035331 | biological_process | negative regulation of hippo signaling |
| A | 0043005 | cellular_component | neuron projection |
| A | 0043025 | cellular_component | neuronal cell body |
| A | 0043029 | biological_process | T cell homeostasis |
| A | 0045202 | cellular_component | synapse |
| A | 0046982 | molecular_function | protein heterodimerization activity |
| A | 0051225 | biological_process | spindle assembly |
| A | 0051232 | biological_process | meiotic spindle elongation |
| A | 0051306 | biological_process | mitotic sister chromatid separation |
| A | 0051754 | biological_process | meiotic sister chromatid cohesion, centromeric |
| A | 0051898 | biological_process | negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| A | 0070262 | biological_process | peptidyl-serine dephosphorylation |
| A | 0090443 | cellular_component | FAR/SIN/STRIPAK complex |
| A | 0098978 | cellular_component | glutamatergic synapse |
| A | 0160232 | cellular_component | INTAC complex |
| A | 0160240 | biological_process | RNA polymerase II transcription initiation surveillance |
| A | 1903538 | biological_process | regulation of meiotic cell cycle process involved in oocyte maturation |
| A | 1990405 | molecular_function | protein antigen binding |
| A | 2001241 | biological_process | positive regulation of extrinsic apoptotic signaling pathway in absence of ligand |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 2","evidences":[{"source":"UniProtKB","id":"P30153","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 38 |
| Details | Repeat: {"description":"HEAT 3","evidences":[{"source":"UniProtKB","id":"P30153","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 4","evidences":[{"source":"UniProtKB","id":"P30153","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 38 |
| Details | Repeat: {"description":"HEAT 5","evidences":[{"source":"UniProtKB","id":"P30153","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 38 |
| Details | Repeat: {"description":"HEAT 6","evidences":[{"source":"UniProtKB","id":"P30153","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 38 |
| Details | Repeat: {"description":"HEAT 7","evidences":[{"source":"UniProtKB","id":"P30153","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"HEAT 8","evidences":[{"source":"UniProtKB","id":"P30153","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 38 |
| Details | Repeat: {"description":"HEAT 9","evidences":[{"source":"UniProtKB","id":"P30153","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 38 |
| Details | Repeat: {"description":"HEAT 10","evidences":[{"source":"UniProtKB","id":"P30153","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 38 |
| Details | Repeat: {"description":"HEAT 11","evidences":[{"source":"UniProtKB","id":"P30153","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 38 |
| Details | Repeat: {"description":"HEAT 12","evidences":[{"source":"UniProtKB","id":"P30153","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 38 |
| Details | Repeat: {"description":"HEAT 13","evidences":[{"source":"UniProtKB","id":"P30153","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 38 |
| Details | Repeat: {"description":"HEAT 14","evidences":[{"source":"UniProtKB","id":"P30153","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"23806337","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
