8GT6

human STING With agonist HB3089

Summary for 8GT6

• Entry DOI: 10.2210/pdb8gt6/pdb
• EMDB information: 34245
• Descriptor: Stimulator of interferon genes protein, 1-[(2E)-4-{5-carbamoyl-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-7-[3-(morpholin-4-yl)propoxy]-1H-benzimidazol-1-yl}but-2-en-1-yl]-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-7-methyl-1H-furo[3,2-e]benzimidazole-5-carboxamide (2 entities in total)
• Functional Keywords: agonist, human sting, immune system
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 85346.90

Authors

Wang, Z.,Yu, X. (deposition date: 2022-09-07, release date: 2022-12-28)

• Primary citation: Xie, Z.,Wang, Z.,Fan, F.,Zhou, J.,Hu, Z.,Wang, Q.,Wang, X.,Zeng, Q.,Zhang, Y.,Qiu, J.,Zhou, X.,Xu, H.,Bai, H.,Zhan, Z.,Ding, J.,Zhang, H.,Duan, W.,Yu, X.,Geng, M.; Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation.; Cell Discov, 8:133-133, 2022; PubMed: 36513640; DOI: 10.1038/s41421-022-00481-4

Experimental method

ELECTRON MICROSCOPY (3.47 Å)