8GSZ

Structure of STING SAVI-related mutant V147L

Summary for 8GSZ

• Entry DOI: 10.2210/pdb8gsz/pdb
• EMDB information: 34244
• Descriptor: Stimulator of interferon genes protein (1 entity in total)
• Functional Keywords: mutant, savi-related, immune system
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 84501.00

Authors

Wang, Z.,Yu, X. (deposition date: 2022-09-07, release date: 2022-12-28)

• Primary citation: Xie, Z.,Wang, Z.,Fan, F.,Zhou, J.,Hu, Z.,Wang, Q.,Wang, X.,Zeng, Q.,Zhang, Y.,Qiu, J.,Zhou, X.,Xu, H.,Bai, H.,Zhan, Z.,Ding, J.,Zhang, H.,Duan, W.,Yu, X.,Geng, M.; Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation.; Cell Discov, 8:133-133, 2022; PubMed: 36513640; DOI: 10.1038/s41421-022-00481-4

Experimental method

ELECTRON MICROSCOPY (3.65 Å)