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8GSZ

Structure of STING SAVI-related mutant V147L

Functional Information from GO Data
ChainGOidnamespacecontents
A0000045biological_processautophagosome assembly
A0000139cellular_componentGolgi membrane
A0000166molecular_functionnucleotide binding
A0000421cellular_componentautophagosome membrane
A0002218biological_processactivation of innate immune response
A0002221biological_processpattern recognition receptor signaling pathway
A0002230biological_processpositive regulation of defense response to virus by host
A0002753biological_processcytoplasmic pattern recognition receptor signaling pathway
A0005515molecular_functionprotein binding
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005741cellular_componentmitochondrial outer membrane
A0005768cellular_componentendosome
A0005776cellular_componentautophagosome
A0005777cellular_componentperoxisome
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006914biological_processautophagy
A0010468biological_processregulation of gene expression
A0015252molecular_functionproton channel activity
A0016239biological_processpositive regulation of macroautophagy
A0019901molecular_functionprotein kinase binding
A0030659cellular_componentcytoplasmic vesicle membrane
A0030667cellular_componentsecretory granule membrane
A0031410cellular_componentcytoplasmic vesicle
A0031625molecular_functionubiquitin protein ligase binding
A0032092biological_processpositive regulation of protein binding
A0032481biological_processpositive regulation of type I interferon production
A0032728biological_processpositive regulation of interferon-beta production
A0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
A0034220biological_processmonoatomic ion transmembrane transport
A0035438molecular_functioncyclic-di-GMP binding
A0035458biological_processcellular response to interferon-beta
A0035591molecular_functionsignaling adaptor activity
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0045087biological_processinnate immune response
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0048471cellular_componentperinuclear region of cytoplasm
A0050727biological_processregulation of inflammatory response
A0051091biological_processpositive regulation of DNA-binding transcription factor activity
A0051259biological_processprotein complex oligomerization
A0051607biological_processdefense response to virus
A0060340biological_processpositive regulation of type I interferon-mediated signaling pathway
A0061507molecular_function2',3'-cyclic GMP-AMP binding
A0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
A0061709biological_processreticulophagy
A0070972biological_processprotein localization to endoplasmic reticulum
A0071360biological_processcellular response to exogenous dsRNA
A0071407biological_processcellular response to organic cyclic compound
A0140374biological_processantiviral innate immune response
A0140896biological_processcGAS/STING signaling pathway
A1902554cellular_componentserine/threonine protein kinase complex
A1902600biological_processproton transmembrane transport
A1990231cellular_componentSTING complex
B0000045biological_processautophagosome assembly
B0000139cellular_componentGolgi membrane
B0000166molecular_functionnucleotide binding
B0000421cellular_componentautophagosome membrane
B0002218biological_processactivation of innate immune response
B0002221biological_processpattern recognition receptor signaling pathway
B0002230biological_processpositive regulation of defense response to virus by host
B0002753biological_processcytoplasmic pattern recognition receptor signaling pathway
B0005515molecular_functionprotein binding
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005741cellular_componentmitochondrial outer membrane
B0005768cellular_componentendosome
B0005776cellular_componentautophagosome
B0005777cellular_componentperoxisome
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006914biological_processautophagy
B0010468biological_processregulation of gene expression
B0015252molecular_functionproton channel activity
B0016239biological_processpositive regulation of macroautophagy
B0019901molecular_functionprotein kinase binding
B0030659cellular_componentcytoplasmic vesicle membrane
B0030667cellular_componentsecretory granule membrane
B0031410cellular_componentcytoplasmic vesicle
B0031625molecular_functionubiquitin protein ligase binding
B0032092biological_processpositive regulation of protein binding
B0032481biological_processpositive regulation of type I interferon production
B0032728biological_processpositive regulation of interferon-beta production
B0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
B0034220biological_processmonoatomic ion transmembrane transport
B0035438molecular_functioncyclic-di-GMP binding
B0035458biological_processcellular response to interferon-beta
B0035591molecular_functionsignaling adaptor activity
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0045087biological_processinnate immune response
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0048471cellular_componentperinuclear region of cytoplasm
B0050727biological_processregulation of inflammatory response
B0051091biological_processpositive regulation of DNA-binding transcription factor activity
B0051259biological_processprotein complex oligomerization
B0051607biological_processdefense response to virus
B0060340biological_processpositive regulation of type I interferon-mediated signaling pathway
B0061507molecular_function2',3'-cyclic GMP-AMP binding
B0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
B0061709biological_processreticulophagy
B0070972biological_processprotein localization to endoplasmic reticulum
B0071360biological_processcellular response to exogenous dsRNA
B0071407biological_processcellular response to organic cyclic compound
B0140374biological_processantiviral innate immune response
B0140896biological_processcGAS/STING signaling pathway
B1902554cellular_componentserine/threonine protein kinase complex
B1902600biological_processproton transmembrane transport
B1990231cellular_componentSTING complex
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues562
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:30842659
ChainResidueDetails
AMET1-GLY17
ALEU70-CYS91
AGLY135-SER379
BMET1-GLY17
BLEU70-CYS91
BGLY135-SER379

site_idSWS_FT_FI2
Number of Residues32
DetailsTRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:30842659
ChainResidueDetails
AALA18-TRP34
BALA18-TRP34

site_idSWS_FT_FI3
Number of Residues36
DetailsTOPO_DOM: Lumenal => ECO:0000269|PubMed:30842659
ChainResidueDetails
AGLY35-LEU44
ATYR107-PRO116
BGLY35-LEU44
BTYR107-PRO116

site_idSWS_FT_FI4
Number of Residues48
DetailsTRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:30842659
ChainResidueDetails
AARG45-GLU69
BARG45-GLU69

site_idSWS_FT_FI5
Number of Residues28
DetailsTRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:30842659
ChainResidueDetails
APRO92-TYR106
BPRO92-TYR106

site_idSWS_FT_FI6
Number of Residues34
DetailsTRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:30842659
ChainResidueDetails
APHE117-LEU134
BPHE117-LEU134

site_idSWS_FT_FI7
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:22728660, ECO:0007744|PDB:4F5Y
ChainResidueDetails
ASER162
BSER162

site_idSWS_FT_FI8
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:22579474, ECO:0000269|PubMed:22705373, ECO:0000269|PubMed:22728658, ECO:0000269|PubMed:22728659, ECO:0000269|PubMed:22728660, ECO:0007744|PDB:4EF4, ECO:0007744|PDB:4EMT, ECO:0007744|PDB:4F5D, ECO:0007744|PDB:4F5Y, ECO:0007744|PDB:4F9G
ChainResidueDetails
ATYR167
BTYR167

site_idSWS_FT_FI9
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:37379839, ECO:0007744|PDB:8GJX
ChainResidueDetails
AARG238
BARG238

site_idSWS_FT_FI10
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:22579474, ECO:0000269|PubMed:22705373, ECO:0000269|PubMed:22728658, ECO:0000269|PubMed:22728660, ECO:0007744|PDB:4EF4, ECO:0007744|PDB:4EMT, ECO:0007744|PDB:4F5Y, ECO:0007744|PDB:4F9G
ChainResidueDetails
ATHR263
BTHR263

site_idSWS_FT_FI11
Number of Residues6
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:37832545
ChainResidueDetails
ATHR229
ATHR354
ATHR356
BTHR229
BTHR354
BTHR356

site_idSWS_FT_FI12
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:37832545
ChainResidueDetails
ASER241
BSER241

site_idSWS_FT_FI13
Number of Residues2
DetailsMOD_RES: Phosphoserine; by MAP3K7 => ECO:0000269|PubMed:37832545
ChainResidueDetails
ASER355
BSER355

site_idSWS_FT_FI14
Number of Residues2
DetailsMOD_RES: Phosphoserine; by TBK1 => ECO:0000269|PubMed:18818105, ECO:0000269|PubMed:25636800
ChainResidueDetails
ASER358
BSER358

site_idSWS_FT_FI15
Number of Residues2
DetailsMOD_RES: Phosphoserine; by TBK1 => ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:32753499
ChainResidueDetails
ASER366
BSER366

site_idSWS_FT_FI16
Number of Residues2
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:Q3TBT3
ChainResidueDetails
ACYS88
BCYS88

site_idSWS_FT_FI17
Number of Residues2
DetailsLIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:29973723
ChainResidueDetails
ACYS91
BCYS91

site_idSWS_FT_FI18
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:19285439, ECO:0000269|PubMed:21074459
ChainResidueDetails
ALYS150
BLYS150

site_idSWS_FT_FI19
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000250|UniProtKB:Q3TBT3
ChainResidueDetails
ALYS338
BLYS338

site_idSWS_FT_FI20
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:31968013
ChainResidueDetails
ALYS236
BLYS236

227111

PDB entries from 2024-11-06

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