3FUR

Crystal Structure of PPARg in complex with INT131

Summary for 3FUR

DescriptorPeroxisome proliferator-activated receptor gamma, Nuclear receptor coactivator 1, 2,4-dichloro-N-[3,5-dichloro-4-(quinolin-3-yloxy)phenyl]benzenesulfonamide, ... (5 entities in total)
Functional Keywordsnuclear receptor, ppargamma, partial agonist, activator, alternative splicing, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphoprotein, polymorphism, receptor, transcription, transcription regulation, zinc, zinc-finger, int131, transcription-transcription regulator complex, transcription/transcription regulator
Biological sourceHomo sapiens (Human)
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Total number of polymer chains2
Total molecular weight32987.37
Authors
Wang, Z.,Liu, J.,Walker, N. (deposition date: 2009-01-14, release date: 2009-06-09, Last modification date: 2019-10-16)
Primary citation
Motani, A.,Wang, Z.,Weiszmann, J.,McGee, L.R.,Lee, G.,Liu, Q.,Staunton, J.,Fang, Z.,Fuentes, H.,Lindstrom, M.,Liu, J.,Biermann, D.H.,Jaen, J.,Walker, N.P.,Learned, R.M.,Chen, J.L.,Li, Y.
INT131: a selective modulator of PPAR gamma.
J.Mol.Biol., 386:1301-1311, 2009
PubMed: 19452630 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2009.01.025
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.3 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.23850 5.0% 6.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report