6UM1
 
 | | Structure of M-6-P/IGFII Receptor at pH 4.5 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cation-independent mannose-6-phosphate receptor, ... | | 著者 | Wang, R, Qi, X, Li, X. | | 登録日 | 2019-10-08 | | 公開日 | 2020-02-26 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (3.46 Å) | | 主引用文献 | Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments
Sci Adv, 6, 2020
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4WVD
 | | Identification of a novel FXR ligand that regulates metabolism | | 分子名称: | (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside, Bile acid receptor, FORMIC ACID, ... | | 著者 | Wang, R, Li, Y. | | 登録日 | 2014-11-05 | | 公開日 | 2015-02-11 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism.
Nat Commun, 4, 2013
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5J5C
 | | Crystal structure of ARL1-GTP and DCB domain of BIG1 complex | | 分子名称: | ADP-ribosylation factor-like protein 1, Brefeldin A-inhibited guanine nucleotide-exchange protein 1, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Wang, R, Wang, Z, Zhang, T, Ding, J. | | 登録日 | 2016-04-02 | | 公開日 | 2016-09-28 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Structural basis for targeting BIG1 to Golgi apparatus through interaction of its DCB domain with Arl1
J Mol Cell Biol, 2016
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5JHG
 | | Crystal structure of the complex between the human RhoA and the DH/PH domain of human ARHGEF11 | | 分子名称: | GLYCEROL, Rho guanine nucleotide exchange factor 11, Transforming protein RhoA | | 著者 | Wang, R, Chen, Q, Zhang, H, Yan, Z, Li, J, Miao, L, Wang, F. | | 登録日 | 2016-04-21 | | 公開日 | 2017-04-26 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystallization and preliminary X-ray crystallographic analysis of a small GTPase RhoA bound with its inhibitor and ARHGEF11
To Be Published
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8Y3M
 | | Cryo-EM structure of DSR2-DSAD1 complex (cross-linked) | | 分子名称: | DSR anti-defence 1, SIR2-like domain-containing protein | | 著者 | Wang, R.W, Xu, Q, Wu, Z.X, Li, J.L, Shi, Z.B, Li, F.X. | | 登録日 | 2024-01-29 | | 公開日 | 2024-09-11 | | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | | 主引用文献 | The structural basis of the activation and inhibition of DSR2 NADase by phage proteins.
Nat Commun, 15, 2024
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8Y3W
 | | The Cryo-EM structure of anti-phage defense associated DSR2 tetramer bound with two DSAD1 inhibitors (same side) | | 分子名称: | DSR anti-defence 1, SIR2-like domain-containing protein | | 著者 | Wang, R.W, Xu, Q, Wu, Z.X, Li, J.L, Shi, Z.B, Li, F.X. | | 登録日 | 2024-01-29 | | 公開日 | 2024-09-11 | | 実験手法 | ELECTRON MICROSCOPY (3.49 Å) | | 主引用文献 | The structural basis of the activation and inhibition of DSR2 NADase by phage proteins.
Nat Commun, 15, 2024
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8Y3Y
 | | The Cryo-EM structure of anti-phage defense associated DSR2 tetramer bound with two DSAD1 inhibitors (opposite side) | | 分子名称: | DSR anti-defence 1, SIR2-like domain-containing protein | | 著者 | Wang, R.W, Xu, Q, Wu, Z.X, Li, J.L, Shi, Z.B, Li, F.X. | | 登録日 | 2024-01-29 | | 公開日 | 2024-09-11 | | 実験手法 | ELECTRON MICROSCOPY (3.33 Å) | | 主引用文献 | The structural basis of the activation and inhibition of DSR2 NADase by phage proteins.
Nat Commun, 15, 2024
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8Y34
 | | Cryo-EM structure of anti-phage defense associated DSR2 (H171A) (map2) | | 分子名称: | SIR2-like domain-containing protein | | 著者 | Wang, R.W, Xu, Q, Wu, Z.X, Li, J.L, Shi, Z.B, Li, F.X. | | 登録日 | 2024-01-28 | | 公開日 | 2024-09-11 | | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | | 主引用文献 | The structural basis of the activation and inhibition of DSR2 NADase by phage proteins.
Nat Commun, 15, 2024
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8ZC9
 | | The Cryo-EM structure of DSR2-Tail tube-NAD+ complex | | 分子名称: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SIR2-like domain-containing protein, tail tube protein | | 著者 | Wang, R, Xu, Q, Wu, Z, Li, J, Yang, R, Shi, Z, Li, F. | | 登録日 | 2024-04-29 | | 公開日 | 2024-09-11 | | 実験手法 | ELECTRON MICROSCOPY (3.14 Å) | | 主引用文献 | The structural basis of the activation and inhibition of DSR2 NADase by phage proteins.
Nat Commun, 15, 2024
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4Y29
 | | Identification of a novel PPARg ligand that regulates metabolism | | 分子名称: | 1,2-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium, Peptide from Nuclear receptor coactivator 1, Peroxisome proliferator-activated receptor gamma | | 著者 | Wang, R, Li, Y. | | 登録日 | 2015-02-09 | | 公開日 | 2015-09-09 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | | 主引用文献 | Selective targeting of PPAR gamma by the natural product chelerythrine with a unique binding mode and improved antidiabetic potency.
Sci Rep, 5, 2015
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5KKN
 | | Crystal structure of human ACC2 BC domain in complex with ND-646, the primary amide of ND-630 | | 分子名称: | 2-[1-[(2~{R})-2-(2-methoxyphenyl)-2-(oxan-4-yloxy)ethyl]-5-methyl-6-(1,3-oxazol-2-yl)-2,4-bis(oxidanylidene)thieno[2,3-d]pyrimidin-3-yl]-2-methyl-propanamide, Acetyl-CoA carboxylase 2 | | 著者 | Wang, R, Paul, D, Tong, L. | | 登録日 | 2016-06-22 | | 公開日 | 2016-07-13 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats.
Proc.Natl.Acad.Sci.USA, 113, 2016
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4U32
 | | Human mesotrypsin complexed with HAI-2 Kunitz domain 1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Kunitz-type protease inhibitor 2, ... | | 著者 | Wang, R, Soares, A.S, Radisky, E.S. | | 登録日 | 2014-07-18 | | 公開日 | 2014-10-15 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Sequence and Conformational Specificity in Substrate Recognition: SEVERAL HUMAN KUNITZ PROTEASE INHIBITOR DOMAINS ARE SPECIFIC SUBSTRATES OF MESOTRYPSIN.
J.Biol.Chem., 289, 2014
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4U30
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6UM2
 | | Structure of M-6-P/IGFII Receptor and IGFII complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cation-independent mannose-6-phosphate receptor, Insulin-like growth factor II | | 著者 | Wang, R, Qi, X, Li, X. | | 登録日 | 2019-10-08 | | 公開日 | 2020-02-26 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (4.32 Å) | | 主引用文献 | Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments
Sci Adv, 6, 2020
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3J9J
 | | Structure of the capsaicin receptor, TRPV1, determined by single particle electron cryo-microscopy | | 分子名称: | Transient receptor potential cation channel subfamily V member 1 | | 著者 | Wang, R.Y.-R, Barad, B.A, Fraser, J.S, DiMaio, F. | | 登録日 | 2015-02-02 | | 公開日 | 2015-09-02 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (3.275 Å) | | 主引用文献 | EMRinger: side chain-directed model and map validation for 3D cryo-electron microscopy.
Nat.Methods, 12, 2015
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3G5B
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6M6L
 | | The crystal structure of glycosidase hydrolyzing Notoginsenoside | | 分子名称: | 1,2-ETHANEDIOL, Beta-glucosidase, GLYCEROL, ... | | 著者 | Wang, R.F. | | 登録日 | 2020-03-15 | | 公開日 | 2021-03-17 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Characterization and Structural Elucidation of Enhanced Catalytic Activity upon Engineering Glycosidase KfGH01 for the Production of Vina-ginsenoside R7
To Be Published
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6M6M
 | | The crystal structure of glycosidase mutant | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Beta-glucosidase | | 著者 | Wang, R.F. | | 登録日 | 2020-03-15 | | 公開日 | 2021-03-17 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | | 主引用文献 | Characterization and Structural Elucidation of Enhanced Catalytic Activity upon Engineering Glycosidase KfGH01 for the Production of Vina-ginsenoside R7
To Be Published
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7SHN
 | | Cryo-EM structure of oleoyl-CoA-bound human peroxisomal fatty acid transporter ABCD1 | | 分子名称: | ATP-binding cassette sub-family D member 1, S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name) | | 著者 | Wang, R, Li, X. | | 登録日 | 2021-10-09 | | 公開日 | 2021-11-03 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural basis of acyl-CoA transport across the peroxisomal membrane by human ABCD1.
Cell Res., 32, 2022
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7SHM
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7KHR
 | | Cryo-EM structure of bafilomycin A1-bound intact V-ATPase from bovine brain | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (5R)-2,4-dideoxy-1-C-{(2S,3R,4S)-3-hydroxy-4-[(2R,3S,4E,6E,9R,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxo-1-oxacyclohexadeca-4,6,12,14-tetraen-2-yl]pentan-2-yl}-4-methyl-5-propan-2-yl-alpha-D-threo-pentopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Wang, R, Li, X. | | 登録日 | 2020-10-21 | | 公開日 | 2021-03-17 | | 最終更新日 | 2021-09-29 | | 実験手法 | ELECTRON MICROSCOPY (3.62 Å) | | 主引用文献 | Molecular basis of V-ATPase inhibition by bafilomycin A1.
Nat Commun, 12, 2021
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8ILB
 | | The complexes of RbcL, AtRaf1 and AtBSD2 (LFB) | | 分子名称: | Protein BUNDLE SHEATH DEFECTIVE 2, chloroplastic, Ribulose bisphosphate carboxylase large chain, ... | | 著者 | Wang, R, Song, H, Zhang, W, Wang, N, Zhang, S, Shao, R. | | 登録日 | 2023-03-03 | | 公開日 | 2023-11-01 | | 最終更新日 | 2023-12-20 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural insights into the functions of Raf1 and Bsd2 in hexadecameric Rubisco assembly.
Mol Plant, 16, 2023
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8ILM
 | | The cryo-EM structure of eight Rubisco large subunits (RbcL), two Arabidopsis thaliana Rubisco accumulation factors 1 (AtRaf1), and seven Arabidopsis thaliana Bundle Sheath Defective 2 (AtBSD2) | | 分子名称: | Protein BUNDLE SHEATH DEFECTIVE 2, chloroplastic, Ribulose bisphosphate carboxylase large chain, ... | | 著者 | Wang, R, Song, H, Zhang, W, Wang, N, Zhang, S, Shao, R. | | 登録日 | 2023-03-03 | | 公開日 | 2023-11-01 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structural insights into the functions of Raf1 and Bsd2 in hexadecameric Rubisco assembly.
Mol Plant, 16, 2023
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3IXS
 | | Ring1B C-terminal domain/RYBP C-terminal domain Complex | | 分子名称: | 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, E3 ubiquitin-protein ligase RING2, ... | | 著者 | Wang, R, Taylor, A.B, Kim, C.A. | | 登録日 | 2009-09-04 | | 公開日 | 2010-08-25 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Polycomb Group Targeting through Different Binding Partners of RING1B C-Terminal Domain.
Structure, 18, 2010
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3GS2
 | | Ring1B C-terminal domain/Cbx7 Cbox Complex | | 分子名称: | Chromobox protein homolog 7, E3 ubiquitin-protein ligase RING2, SULFATE ION, ... | | 著者 | Wang, R, Taylor, A.B, Kim, C.A. | | 登録日 | 2009-03-26 | | 公開日 | 2010-08-25 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.699 Å) | | 主引用文献 | Polycomb Group Targeting through Different Binding Partners of RING1B C-Terminal Domain.
Structure, 18, 2010
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