Identification of a novel PPARg ligand that regulates metabolism

Summary for 4Y29

DescriptorPeroxisome proliferator-activated receptor gamma, Peptide from Nuclear receptor coactivator 1, 1,2-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium, ... (4 entities in total)
Functional Keywordsaf-2 helix, ligand binding pocket, three-layer helical sandwich, transcription regulator pparg, nr1c3, peroxisome proliferator-activated receptor gamma, nhr, nuclear receptor, coactivator, transcription factor, dna binding protein-transcription complex, dna binding protein/transcription
Biological sourceHomo sapiens (Human)
Cellular locationNucleus P37231 Q15788
Total number of polymer chains2
Total molecular weight32226.49
Wang, R.,Li, Y. (deposition date: 2015-02-09, release date: 2015-09-09)
Primary citation
Zheng, W.L.,Qiu, L.,Wang, R.,Feng, X.H.,Han, Y.P.,Zhu, Y.L.,Chen, D.Z.,Liu, Y.J.,Jin, L.H.,Li, Y.
Selective targeting of PPAR gamma by the natural product chelerythrine with a unique binding mode and improved antidiabetic potency.
Sci Rep, 5:12222-12222, 2015
PubMed: 26183621 (PDB entries with the same primary citation)
DOI: 10.1038/srep12222
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.21992.3%2.9%6.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report