2KQT
 
 | | Solid-state NMR structure of the M2 transmembrane peptide of the influenza A virus in DMPC lipid bilayers bound to deuterated amantadine | | Descriptor: | (3S,5S,7S)-tricyclo[3.3.1.1~3,7~]decan-1-amine, M2 protein | | Authors: | Cady, S.D, Schmidt-Rohr, K, Wang, J, Soto, C.S, DeGrado, W.F, Hong, M. | | Deposit date: | 2009-11-18 | | Release date: | 2010-02-09 | | Last modified: | 2024-05-08 | | Method: | SOLID-STATE NMR | | Cite: | Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers
Nature, 463, 2010
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6WGJ
 | | Fab portion of dupilumab with Crystal Kappa design and no interchain disulfide | | Descriptor: | Dupilumab Fab heavy chain, Dupilumab Fab light chain | | Authors: | Druzina, Z, Atwell, S, Pustilnik, A, Antonysamy, S, Ho, C, Lieu, R, Hendle, J, Benach, J, Wang, J. | | Deposit date: | 2020-04-05 | | Release date: | 2020-09-16 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Rapid and robust antibody Fab fragment crystallization utilizing edge-to-edge beta-sheet packing.
Plos One, 15, 2020
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6J94
 | | Crystal structure of CYP97A3 | | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, Protein LUTEIN DEFICIENT 5, chloroplastic | | Authors: | Niu, G, Guo, Q, Wang, J, Zhao, S. | | Deposit date: | 2019-01-22 | | Release date: | 2020-01-22 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.401 Å) | | Cite: | Structural basis for plant lutein biosynthesis from alpha-carotene.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6J95
 | | Crystal structure of CYP97A3 in complex with retinal | | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, Protein LUTEIN DEFICIENT 5, chloroplastic, ... | | Authors: | Niu, G, Guo, Q, Wang, J, Zhao, S. | | Deposit date: | 2019-01-22 | | Release date: | 2020-01-22 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.002 Å) | | Cite: | Structural basis for plant lutein biosynthesis from alpha-carotene.
Proc.Natl.Acad.Sci.USA, 117, 2020
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5YR3
 | | Structure of sfYFP66BPA | | Descriptor: | Yellow fluorescent protein | | Authors: | Kang, F, Wang, L, Wang, J. | | Deposit date: | 2017-11-08 | | Release date: | 2019-01-30 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.901 Å) | | Cite: | sfYFP66BPA
To Be Published
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5YR2
 | | Structure of cpGFP66BPA | | Descriptor: | Green fluorescent protein | | Authors: | Wang, L, Kang, F, Wang, J. | | Deposit date: | 2017-11-08 | | Release date: | 2019-01-30 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.799 Å) | | Cite: | Structure of cpGFP66BPA
To Be Published
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8IA3
 | | Crystal structure of human USF2 bHLHLZ domain in complex with DNA | | Descriptor: | DNA (5'-D(*GP*CP*GP*CP*GP*TP*CP*AP*CP*GP*TP*GP*CP*CP*CP*GP*TP*C)-3'), DNA (5'-D(P*GP*AP*CP*GP*GP*GP*CP*AP*CP*GP*TP*GP*AP*CP*GP*CP*GP*C)-3'), Upstream stimulatory factor 2 | | Authors: | Huang, C, Fang, P, Wang, J. | | Deposit date: | 2023-02-07 | | Release date: | 2023-09-20 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Tetramerization of upstream stimulating factor USF2 requires the elongated bent leucine zipper of the bHLH-LZ domain.
J.Biol.Chem., 299, 2023
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8GTY
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3K2L
 | | Crystal Structure of dual-specificity tyrosine phosphorylation regulated kinase 2 (DYRK2) | | Descriptor: | CHLORIDE ION, Dual specificity tyrosine-phosphorylation-regulated kinase 2, SODIUM ION, ... | | Authors: | Filippakopoulos, P, Myrianthopoulos, V, Soundararajan, M, Krojer, T, Hapka, E, Fedorov, O, Berridge, G, Wang, J, Shrestha, L, Pike, A.C.W, Ugochukwu, E, von Delft, F, Arrowsmith, C.H, Edwards, A, Weigelt, J, Bountra, C, Mikros, E, Knapp, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2009-09-30 | | Release date: | 2009-10-13 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.36 Å) | | Cite: | Structures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate Recognition.
Structure, 21, 2013
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6KHR
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6L02
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6IJZ
 | | Structure of a plant cation channel | | Descriptor: | Calcium permeable stress-gated cation channel 1 | | Authors: | Sun, L, Wang, J, Liu, X. | | Deposit date: | 2018-10-12 | | Release date: | 2018-12-12 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.68 Å) | | Cite: | Structure of the hyperosmolality-gated calcium-permeable channel OSCA1.2.
Nat Commun, 9, 2018
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7CR2
 | | human KCNQ2 in complex with retigabine | | Descriptor: | Potassium voltage-gated channel subfamily KQT member 2, ethyl N-[2-azanyl-4-[(4-fluorophenyl)methylamino]phenyl]carbamate | | Authors: | Li, X, Lv, D, Wang, J, Ye, S, Guo, J. | | Deposit date: | 2020-08-12 | | Release date: | 2020-09-16 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Molecular basis for ligand activation of the human KCNQ2 channel.
Cell Res., 31, 2021
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2K6B
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7CRC
 | | Cryo-EM structure of plant NLR RPP1 tetramer in complex with ATR1 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Avirulence protein ATR1, ... | | Authors: | Ma, S.C, Lapin, D, Liu, L, Sun, Y, Song, W, Zhang, X.X, Logemann, E, Yu, D.L, Wang, J, Jirschitzka, J, Han, Z.F, SchulzeLefert, P, Parker, J.E, Chai, J.J. | | Deposit date: | 2020-08-13 | | Release date: | 2020-12-16 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.02 Å) | | Cite: | Direct pathogen-induced assembly of an NLR immune receptor complex to form a holoenzyme.
Science, 370, 2020
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5Y3R
 | | Cryo-EM structure of Human DNA-PK Holoenzyme | | Descriptor: | DNA (34-MER), DNA (36-MER), DNA-dependent protein kinase catalytic subunit, ... | | Authors: | Yin, X, Liu, M, Tian, Y, Wang, J, Xu, Y. | | Deposit date: | 2017-07-29 | | Release date: | 2017-09-06 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (6.6 Å) | | Cite: | Cryo-EM structure of human DNA-PK holoenzyme
Cell Res., 27, 2017
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2LAC
 | | NMR structure of unmodified_ASL_Tyr | | Descriptor: | RNA (5'-R(*GP*GP*GP*GP*AP*CP*UP*GP*UP*AP*AP*AP*UP*CP*CP*CP*C)-3') | | Authors: | Denmon, A.P, Wang, J, Nikonowicz, E.P. | | Deposit date: | 2011-03-10 | | Release date: | 2011-08-03 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Conformation Effects of Base Modification on the Anticodon Stem-Loop of Bacillus subtilis tRNA(Tyr).
J.Mol.Biol., 412, 2011
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2LBR
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2LBQ
 | | NMR structure of i6A37_tyrASL | | Descriptor: | RNA (5'-R(*GP*GP*GP*GP*AP*CP*UP*GP*UP*AP*(6IA)P*AP*UP*CP*CP*CP*C)-3') | | Authors: | Denmon, A.P, Wang, J, Nikonowicz, E.P. | | Deposit date: | 2011-04-05 | | Release date: | 2011-08-03 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Conformation Effects of Base Modification on the Anticodon Stem-Loop of Bacillus subtilis tRNA(Tyr).
J.Mol.Biol., 412, 2011
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2M00
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2MUV
 | | NOE-based model of the influenza A virus M2 (19-49) bound to drug 11 | | Descriptor: | (3s,5s,7s)-N-[(5-bromothiophen-2-yl)methyl]tricyclo[3.3.1.1~3,7~]decan-1-aminium, Matrix protein 2 | | Authors: | Wu, Y, Wang, J, DeGrado, W. | | Deposit date: | 2014-09-18 | | Release date: | 2014-12-24 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Flipping in the Pore: Discovery of Dual Inhibitors That Bind in Different Orientations to the Wild-Type versus the Amantadine-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel.
J.Am.Chem.Soc., 136, 2014
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2Y7B
 | | Crystal structure of the PH domain of human Actin-binding protein anillin ANLN | | Descriptor: | 1,2-ETHANEDIOL, ACTIN-BINDING PROTEIN ANILLIN | | Authors: | Vollmar, M, Wang, J, Krojer, T, Elkins, J, Filippakopoulos, P, Ugochukwu, E, Cocking, R, von Delft, F, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A, Knapp, S. | | Deposit date: | 2011-01-31 | | Release date: | 2011-03-30 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal Structure of the Ph Domain of Human Actin-Binding Protein Anillin Anln
To be Published
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1X7A
 | | Porcine Factor IXa Complexed to 1-{3-[amino(imino)methyl]phenyl}-N-[4-(1H-benzimidazol-1-yl)-2-fluorophenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide | | Descriptor: | 1-{3-[AMINO(IMINO)METHYL]PHENYL}-N-[4-(1H-BENZIMIDAZOL-1-YL)-2-FLUOROPHENYL]-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-5-CARBOXAMIDE, Coagulation Factor IX, light chain, ... | | Authors: | Alexander, R.S, Smallwood, A.M, Smallheer, J.M, Wang, J, Wang, S, Nakajima, S, Rossi, K.A, Barbera, F, Burdick, D, Luettgen, J.M. | | Deposit date: | 2004-08-13 | | Release date: | 2005-08-16 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | SAR and factor IXa crystal structure of a dual inhibitor of factors IXa and Xa
Bioorg.Med.Chem.Lett., 14, 2004
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2MUW
 | | NOE-based model of the influenza A virus N31S mutant (19-49) bound to drug 11 | | Descriptor: | (3s,5s,7s)-N-[(5-bromothiophen-2-yl)methyl]tricyclo[3.3.1.1~3,7~]decan-1-aminium, Matrix protein 2 | | Authors: | Wu, Y, Wang, J, DeGrado, W. | | Deposit date: | 2014-09-18 | | Release date: | 2014-12-24 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Flipping in the Pore: Discovery of Dual Inhibitors That Bind in Different Orientations to the Wild-Type versus the Amantadine-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel.
J.Am.Chem.Soc., 136, 2014
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6A4I
 | | Crystal Structure of human TDO inhibitor complex | | Descriptor: | 1-(6-chloro-1H-indazol-4-yl)cyclohexan-1-ol, CITRIC ACID, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Fu, G, Wang, J, Luo, G, Wu, G, Qian, K. | | Deposit date: | 2018-06-20 | | Release date: | 2018-07-18 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Crystal Structure of human TDO inhibitor complex
To Be Published
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