2MUW

NOE-based model of the influenza A virus N31S mutant (19-49) bound to drug 11

Summary for 2MUW

• Entry DOI: 10.2210/pdb2muw/pdb
• Related: 2MUV
• NMR Information: BMRB: 25234
• Descriptor: Matrix protein 2, (3s,5s,7s)-N-[(5-bromothiophen-2-yl)methyl]tricyclo[3.3.1.1~3,7~]decan-1-aminium (2 entities in total)
• Functional Keywords: drug design, m2, viral protein
• Biological source: Influenza A virus
• Cellular location: Virion membrane : B0LX40
• Total number of polymer chains: 4
• Total formula weight: 14207.67

Authors

Wu, Y.,Wang, J.,DeGrado, W. (deposition date: 2014-09-18, release date: 2014-12-24, Last modification date: 2023-06-14)

• Primary citation: Wu, Y.,Canturk, B.,Jo, H.,Ma, C.,Gianti, E.,Klein, M.L.,Pinto, L.H.,Lamb, R.A.,Fiorin, G.,Wang, J.,DeGrado, W.F.; Flipping in the Pore: Discovery of Dual Inhibitors That Bind in Different Orientations to the Wild-Type versus the Amantadine-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel.; J.Am.Chem.Soc., 136:17987-17995, 2014; PubMed: 25470189; DOI: 10.1021/ja508461m

Experimental method

SOLUTION NMR