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1X7A

Porcine Factor IXa Complexed to 1-{3-[amino(imino)methyl]phenyl}-N-[4-(1H-benzimidazol-1-yl)-2-fluorophenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Summary for 1X7A
Entry DOI10.2210/pdb1x7a/pdb
Related1PFX
DescriptorCoagulation Factor IXa, Coagulation Factor IX, light chain, 1-{3-[AMINO(IMINO)METHYL]PHENYL}-N-[4-(1H-BENZIMIDAZOL-1-YL)-2-FLUOROPHENYL]-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-5-CARBOXAMIDE (3 entities in total)
Functional Keywordsinhibition; x-ray structure, blood clotting, hydrolase
Biological sourceSus scrofa (pig)
More
Cellular locationSecreted: P16293 P16293
Total number of polymer chains2
Total formula weight43018.47
Authors
Alexander, R.S.,Smallwood, A.M.,Smallheer, J.M.,Wang, J.,Wang, S.,Nakajima, S.,Rossi, K.A.,Barbera, F.,Burdick, D.,Luettgen, J.M. (deposition date: 2004-08-13, release date: 2005-08-16, Last modification date: 2011-07-13)
Primary citationSmallheer, J.M.,Alexander, R.S.,Wang, J.,Wang, S.,Nakajima, S.,Rossi, K.A.,Smallwood, A.,Barbera, F.,Burdick, D.,Luettgen, J.M.,Knabb, R.M.,Wexler, R.R.,Jadhav, P.K.
SAR and factor IXa crystal structure of a dual inhibitor of factors IXa and Xa
Bioorg.Med.Chem.Lett., 14:5263-5267, 2004
Cited by
PubMed: 15454208
DOI: 10.1016/j.bmcl.2004.08.034
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.9 Å)
Structure validation

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