1X7A

Porcine Factor IXa Complexed to 1-{3-[amino(imino)methyl]phenyl}-N-[4-(1H-benzimidazol-1-yl)-2-fluorophenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0004252	molecular_function	serine-type endopeptidase activity
C	0006508	biological_process	proteolysis
L	0005509	molecular_function	calcium ion binding
L	0005576	cellular_component	extracellular region

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE 187 C 298

Chain	Residue
C	ASN97
C	ILE213
C	SER214
C	TRP215
C	GLY216
C	GLU217
C	GLU219
C	CYS220
C	GLY226
C	TYR99
C	ARG143
C	PHE174
C	ASP189
C	SER190
C	CYS191
C	GLN192
C	SER195

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Functional Information from PROSITE/UniProt

site_id	PS01186
Number of Residues	12
Details	EGF_2 EGF-like domain signature 2. CwCqvGFegkn....C

Chain	Residue	Details
L	CYS71-CYS82
L	CYS109-CYS124

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site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VTAAHC

Chain	Residue	Details
C	VAL53-CYS58

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site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPHV

Chain	Residue	Details
C	ASP189-VAL200

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site_id	PS00010
Number of Residues	12
Details	ASX_HYDROXYL Aspartic acid and asparagine hydroxylation site. CkDdinsYeCwC

Chain	Residue	Details
L	CYS62-CYS73

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site_id	PS00011
Number of Residues	26
Details	GLA_1 Vitamin K-dependent carboxylation domain. EciEEkCsfeearEvfentektne.FW

Chain	Residue	Details
L	GLU17-TRP42

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site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CwCqvGfeGKnC

Chain	Residue	Details
L	CYS71-CYS82

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site_id	PS01187
Number of Residues	25
Details	EGF_CA Calcium-binding EGF-like domain signature. DgDQCepnp..........Clnggl..CkDdinsYeC

Chain	Residue	Details
L	ASP47-CYS71

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	BINDING: via 4-carboxyglutamate => ECO:0000250|UniProtKB:P00740

Chain	Residue	Details
L	SER3
L	GLY4
L	GLU7
L	ASN13
L	GLU17

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P00740

Chain	Residue	Details
L	SER24
C	ILE213
L	PHE25
L	GLU27
L	PHE41
L	TRP42
C	VAL203
C	GLY205
C	PHE208
C	THR210

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Cleavage; by factor XIa => ECO:0000250|UniProtKB:P00740

Chain	Residue	Details
L	SER123
C	ARG150

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site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: 4-carboxyglutamate => ECO:0000250|UniProtKB:P00741, ECO:0000255|PROSITE-ProRule:PRU00463

Chain	Residue	Details
L	SER3
L	GLY4
L	GLU7
L	VAL10
L	ASN13
L	GLU17

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: (3R)-3-hydroxyaspartate => ECO:0000250|UniProtKB:P00740

Chain	Residue	Details
L	PHE41
C	THR129

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site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P00740

Chain	Residue	Details
L	TYR45
L	SER136

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site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Sulfotyrosine => ECO:0000250|UniProtKB:P00740

Chain	Residue	Details
L	GLY133

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site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphothreonine; alternate => ECO:0000250|UniProtKB:P00740

Chain	Residue	Details
L	VAL137

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site_id	SWS_FT_FI9
Number of Residues	1
Details	CARBOHYD: O-linked (GalNAc...) threonine; alternate => ECO:0000250|UniProtKB:P00740

Chain	Residue	Details
L	VAL137

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site_id	SWS_FT_FI10
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
C	TRP141
C	TYR228

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