4DST
| Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity | Descriptor: | 1,2-ETHANEDIOL, 2-(4,6-dichloro-2-methyl-1H-indol-3-yl)ethanamine, ACETATE ION, ... | Authors: | Oh, A, Maurer, T, Garrenton, L.S, Pitts, K, Anderson, D.J, Skelton, N.J, Fauber, B.P, Pan, B, Malek, S, Stokoe, D, Ludlam, M, Bowman, K.K, Wu, J, Giannetti, A.M, Starovasnik, M.A, Mellman, I, Jackson, P.K, Ruldolph, J, Fang, G, Wang, W. | Deposit date: | 2012-02-19 | Release date: | 2012-04-04 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity. Proc.Natl.Acad.Sci.USA, 109, 2012
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7YD2
| SulE_P44R_S209A | Descriptor: | 2-[(4-chloranyl-6-methoxy-pyrimidin-2-yl)carbamoylsulfamoyl]benzoic acid, 2-[[[[(4-CHLORO-6-METHOXY-2-PYRIMIDINYL)AMINO]CARBONYL]AMINO]SULFONYL]BENZOIC ACID ETHYL ESTER, Alpha/beta fold hydrolase, ... | Authors: | Liu, B, Ran, T, Wang, W, He, J. | Deposit date: | 2022-07-03 | Release date: | 2023-07-19 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.61 Å) | Cite: | Crystal structures of herbicide-detoxifying esterase reveal a lid loop affecting substrate binding and activity. Nat Commun, 14, 2023
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7Y0L
| SulE-S209A | Descriptor: | Alpha/beta fold hydrolase, GLYCEROL, METHYL 2-[({[(4-METHOXY-6-METHYL-1,3,5-TRIAZIN-2-YL)AMINO]CARBONYL}AMINO)SULFONYL]BENZOATE | Authors: | Liu, B, Ran, T, He, J, Wang, W. | Deposit date: | 2022-06-05 | Release date: | 2023-08-02 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.29 Å) | Cite: | Crystal structures of herbicide-detoxifying esterase reveal a lid loop affecting substrate binding and activity. Nat Commun, 14, 2023
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7KED
| RNA polymerase II elongation complex with unnatural base dTPT3 | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... | Authors: | Oh, J, Wang, W, Wang, D. | Deposit date: | 2020-10-10 | Release date: | 2021-06-23 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Transcriptional processing of an unnatural base pair by eukaryotic RNA polymerase II. Nat.Chem.Biol., 17, 2021
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8HEH
| Crystal structure of GCN5-related N-acetyltransferase 05790 | Descriptor: | COENZYME A, GLYCEROL, GNAT family N-acetyltransferase | Authors: | Xu, M.X, Ran, T.T, Wang, W. | Deposit date: | 2022-11-08 | Release date: | 2022-12-21 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Crystal structure of prodigiosin binding protein PgbP, a GNAT family protein, in Serratia marcescens FS14. Biochem.Biophys.Res.Commun., 640, 2022
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4DSN
| Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity | Descriptor: | 1,2-ETHANEDIOL, GTPase KRas, isoform 2B, ... | Authors: | Oh, A, Maurer, T, Garrenton, L.S, Pitts, K, Anderson, D.J, Skelton, N.J, Fauber, B.P, Pan, B, Malek, S, Stokoe, D, Ludlam, M, Bowman, K.K, Wu, J, Giannetti, A.M, Starovasnik, M.A, Mellman, I, Jackson, P.K, Ruldolph, J, Fang, G, Wang, W. | Deposit date: | 2012-02-19 | Release date: | 2012-04-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity. Proc.Natl.Acad.Sci.USA, 109, 2012
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8H4E
| Blasnase-T13A/P55N with D-asn | Descriptor: | D-ASPARAGINE, FORMIC ACID, L-asparaginase, ... | Authors: | Lu, F, Wang, W, Chi, H, Ran, T. | Deposit date: | 2022-10-10 | Release date: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Structure-based rational design of Bacillus licheniformis L-asparaginase with low/no D-asparaginase activity for a safer enzyme To Be Published
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8H46
| Blasnase-T13A/P55N with L-asn | Descriptor: | ASPARAGINE, FORMIC ACID, GLYCEROL, ... | Authors: | Lu, F, Wang, W, Chi, H, Ran, T. | Deposit date: | 2022-10-10 | Release date: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure-based rational design of Bacillus licheniformis L-asparaginase with low/no D-asparaginase activity for a safer enzyme To Be Published
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8H47
| Blasnase-T13A/P55F | Descriptor: | FORMIC ACID, GLYCEROL, L-asparaginase, ... | Authors: | Lu, F, Wang, W, Chi, H, Ran, T. | Deposit date: | 2022-10-10 | Release date: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure-based rational design of Bacillus licheniformis L-asparaginase with low/no D-asparaginase activity for a safer enzyme To Be Published
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8H4B
| Blasnase-T13A/M57P with L-asn | Descriptor: | ASPARAGINE, FORMIC ACID, L-asparaginase, ... | Authors: | Lu, F, Wang, W, Chi, H, Ran, T. | Deposit date: | 2022-10-10 | Release date: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure-based rational design of Bacillus licheniformis L-asparaginase with low/no D-asparaginase activity for a safer enzyme To Be Published
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8H4D
| Blasnase-T13A/M57N | Descriptor: | FORMIC ACID, GLYCEROL, L-asparaginase, ... | Authors: | Lu, F, Wang, W, Chi, H, Ran, T. | Deposit date: | 2022-10-10 | Release date: | 2023-10-18 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure-based rational design of Bacillus licheniformis L-asparaginase with low/no D-asparaginase activity for a safer enzyme To Be Published
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8H44
| Blasnase-P55N | Descriptor: | FORMIC ACID, L-asparaginase, MAGNESIUM ION | Authors: | Lu, F, Wang, W, Chi, H, Ran, T. | Deposit date: | 2022-10-10 | Release date: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure-based rational design of Bacillus licheniformis L-asparaginase with low/no D-asparaginase activity for a safer enzyme To Be Published
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8H45
| Blasnase-T13A/P55N | Descriptor: | FORMIC ACID, L-asparaginase, MAGNESIUM ION | Authors: | Lu, F, Wang, W, Chi, H, Ran, T. | Deposit date: | 2022-10-10 | Release date: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Structure-based rational design of Bacillus licheniformis L-asparaginase with low/no D-asparaginase activity for a safer enzyme To Be Published
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8H48
| Blasnase-T13A/P55F with L-asn | Descriptor: | ASPARAGINE, FORMIC ACID, L-asparaginase, ... | Authors: | Lu, F, Wang, W, Chi, H, Ran, T. | Deposit date: | 2022-10-10 | Release date: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure-based rational design of Bacillus licheniformis L-asparaginase with low/no D-asparaginase activity for a safer enzyme To Be Published
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8H49
| Blasnase-M57P | Descriptor: | FORMIC ACID, L-asparaginase, MAGNESIUM ION | Authors: | Lu, F, Wang, W, Chi, H, Ran, T. | Deposit date: | 2022-10-10 | Release date: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure-based rational design of Bacillus licheniformis L-asparaginase with low/no D-asparaginase activity for a safer enzyme To Be Published
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8H4A
| Blasnase-T13A/M57P | Descriptor: | FORMIC ACID, L-asparaginase, MAGNESIUM ION | Authors: | Lu, F, Wang, W, Chi, H, Ran, T. | Deposit date: | 2022-10-10 | Release date: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure-based rational design of Bacillus licheniformis L-asparaginase with low/no D-asparaginase activity for a safer enzyme To Be Published
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8H4C
| Blasnase-T13A/M57P | Descriptor: | FORMIC ACID, L-asparaginase, MAGNESIUM ION | Authors: | Lu, F, Wang, W, Chi, H, Ran, T. | Deposit date: | 2022-10-10 | Release date: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure-based rational design of Bacillus licheniformis L-asparaginase with low/no D-asparaginase activity for a safer enzyme To Be Published
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8H4G
| Blasnase-T13A/M57N | Descriptor: | FORMIC ACID, L-asparaginase, MAGNESIUM ION | Authors: | Lu, F, Wang, W, Chi, H, Ran, T. | Deposit date: | 2022-10-10 | Release date: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Structure-based rational design of Bacillus licheniformis L-asparaginase with low/no D-asparaginase activity for a safer enzyme To Be Published
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8H4F
| Blasnase-T13A/P55F with D-asn | Descriptor: | D-ASPARAGINE, FORMIC ACID, L-asparaginase, ... | Authors: | Lu, F, Wang, W, Chi, H, Ran, T. | Deposit date: | 2022-10-10 | Release date: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure-based rational design of Bacillus licheniformis L-asparaginase with low/no D-asparaginase activity for a safer enzyme To Be Published
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8IVM
| crystal structure of SulE mutant | Descriptor: | Alpha/beta fold hydrolase, GLYCEROL, L(+)-TARTARIC ACID, ... | Authors: | Liu, B, He, J, Ran, T, Wang, W. | Deposit date: | 2023-03-28 | Release date: | 2023-08-02 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.32 Å) | Cite: | Crystal structures of herbicide-detoxifying esterase reveal a lid loop affecting substrate binding and activity. Nat Commun, 14, 2023
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4GV6
| Structures of Lassa and Tacaribe viral nucleoproteins with or without 5 triphosphate dsRNA substrate reveal a unique 3 -5 exoribonuclease mechanism to suppress type I interferon production | Descriptor: | MANGANESE (II) ION, Nucleoprotein, RNA (5'-R(*(GTP)P*GP*GP*C)-3'), ... | Authors: | Jiang, X, Huang, Q, Wang, W, Dong, H, Ly, H, Liang, Y, Dong, C. | Deposit date: | 2012-08-30 | Release date: | 2013-05-01 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Structures of Arenaviral Nucleoproteins with Triphosphate dsRNA Reveal a Unique Mechanism of Immune Suppression. J.Biol.Chem., 288, 2013
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7E2P
| The Crystal Structure of Mycoplasma bovis enolase | Descriptor: | Enolase | Authors: | Chen, R, Zhang, S, Gan, R, Wang, W, Ran, T, Shao, G, Xiong, Q, Feng, Z. | Deposit date: | 2021-02-07 | Release date: | 2022-02-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Evidence for the Rapid and Divergent Evolution of Mycoplasmas: Structural and Phylogenetic Analysis of Enolases. Front Mol Biosci, 8, 2022
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8IVS
| crystal structure of SulE mutant | Descriptor: | Alpha/beta fold hydrolase, GLYCEROL, L(+)-TARTARIC ACID, ... | Authors: | Liu, B, He, J, Ran, T, Wang, W. | Deposit date: | 2023-03-28 | Release date: | 2023-08-02 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.52 Å) | Cite: | Crystal structures of herbicide-detoxifying esterase reveal a lid loop affecting substrate binding and activity. Nat Commun, 14, 2023
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8IW6
| crystal structure of SulE mutant | Descriptor: | Alpha/beta fold hydrolase, GLYCEROL, L(+)-TARTARIC ACID, ... | Authors: | Liu, B, He, J, Ran, T, Wang, W. | Deposit date: | 2023-03-29 | Release date: | 2023-08-02 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.44 Å) | Cite: | Crystal structures of herbicide-detoxifying esterase reveal a lid loop affecting substrate binding and activity. Nat Commun, 14, 2023
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4GVE
| Tacaribe nucleoprotein structure | Descriptor: | MAGNESIUM ION, Nucleoprotein, ZINC ION | Authors: | Jiang, X, Huang, Q, Wang, W, Dong, H, Ly, H, Liang, Y, Dong, C. | Deposit date: | 2012-08-30 | Release date: | 2013-05-01 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Structures of Arenaviral Nucleoproteins with Triphosphate dsRNA Reveal a Unique Mechanism of Immune Suppression. J.Biol.Chem., 288, 2013
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