4L4M

Structural Analysis of a Phosphoribosylated Inhibitor in Complex with Human Nicotinamide Phosphoribosyltransferase

Summary for 4L4M

• Entry DOI: 10.2210/pdb4l4m/pdb
• Related: 4L4L
• Descriptor: Nicotinamide phosphoribosyltransferase, N-{4-[(3,5-difluorophenyl)sulfonyl]benzyl}imidazo[1,2-a]pyridine-7-carboxamide, PHOSPHATE ION, ... (5 entities in total)
• Functional Keywords: transferase, inhibitor, active site, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P43490
• Total number of polymer chains: 2
• Total formula weight: 115243.62

Authors

Oh, A.,Ho, Y.,Zak, M.,Liu, Y.,Yuen, P.,Zheng, X.,Dragovich, S.P.,Wang, W. (deposition date: 2013-06-08, release date: 2014-06-11, Last modification date: 2024-02-28)

• Primary citation: Oh, A.,Ho, Y.C.,Zak, M.,Liu, Y.,Chen, X.,Yuen, P.W.,Zheng, X.,Liu, Y.,Dragovich, P.S.,Wang, W.; Structural and biochemical analyses of the catalysis and potency impact of inhibitor phosphoribosylation by human nicotinamide phosphoribosyltransferase.; Chembiochem, 15:1121-1130, 2014; PubMed: 24797455; DOI: 10.1002/cbic.201402023

Experimental method

X-RAY DIFFRACTION (2.445 Å)