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4L4M

Structural Analysis of a Phosphoribosylated Inhibitor in Complex with Human Nicotinamide Phosphoribosyltransferase

Functional Information from GO Data
ChainGOidnamespacecontents
A0005125molecular_functioncytokine activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0007165biological_processsignal transduction
A0007267biological_processcell-cell signaling
A0007623biological_processcircadian rhythm
A0008284biological_processpositive regulation of cell population proliferation
A0008286biological_processinsulin receptor signaling pathway
A0009435biological_processNAD biosynthetic process
A0016607cellular_componentnuclear speck
A0016757molecular_functionglycosyltransferase activity
A0019363biological_processpyridine nucleotide biosynthetic process
A0030054cellular_componentcell junction
A0032922biological_processcircadian regulation of gene expression
A0034356biological_processNAD biosynthesis via nicotinamide riboside salvage pathway
A0042802molecular_functionidentical protein binding
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0047280molecular_functionnicotinamide phosphoribosyltransferase activity
A0048511biological_processrhythmic process
A0051770biological_processpositive regulation of nitric-oxide synthase biosynthetic process
A0060612biological_processadipose tissue development
A0070062cellular_componentextracellular exosome
B0005125molecular_functioncytokine activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0007165biological_processsignal transduction
B0007267biological_processcell-cell signaling
B0007623biological_processcircadian rhythm
B0008284biological_processpositive regulation of cell population proliferation
B0008286biological_processinsulin receptor signaling pathway
B0009435biological_processNAD biosynthetic process
B0016607cellular_componentnuclear speck
B0016757molecular_functionglycosyltransferase activity
B0019363biological_processpyridine nucleotide biosynthetic process
B0030054cellular_componentcell junction
B0032922biological_processcircadian regulation of gene expression
B0034356biological_processNAD biosynthesis via nicotinamide riboside salvage pathway
B0042802molecular_functionidentical protein binding
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0047280molecular_functionnicotinamide phosphoribosyltransferase activity
B0048511biological_processrhythmic process
B0051770biological_processpositive regulation of nitric-oxide synthase biosynthetic process
B0060612biological_processadipose tissue development
B0070062cellular_componentextracellular exosome
Functional Information from PDB Data
site_idAC1
Number of Residues15
DetailsBINDING SITE FOR RESIDUE 1XD A 601
ChainResidue
ATYR188
AARG311
AILE351
APO4602
AHOH796
AHOH826
BTYR18
AHIS191
APHE193
AARG196
AASP219
AVAL242
AALA244
ASER275
AILE309

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE PO4 A 602
ChainResidue
AGLU246
AHIS247
AARG311
A1XD601
AHOH757
BTYR18
BHOH781

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE PO4 A 603
ChainResidue
AARG40
AARG392
ASER398
ALYS400
AHOH780
AHOH836
BHOH786

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO A 604
ChainResidue
AASP313
AASP354
BLYS423
BPO4602

site_idAC5
Number of Residues12
DetailsBINDING SITE FOR RESIDUE 1XD B 601
ChainResidue
ATYR18
BTYR188
BHIS191
BPHE193
BARG196
BASP219
BVAL242
BALA244
BSER275
BILE309
BARG311
BILE351

site_idAC6
Number of Residues7
DetailsBINDING SITE FOR RESIDUE PO4 B 602
ChainResidue
AEDO604
BARG40
BARG392
BSER398
BLYS400
BHOH717
BHOH781

site_idAC7
Number of Residues6
DetailsBINDING SITE FOR RESIDUE PO4 B 603
ChainResidue
ATYR18
BARG196
BGLU246
BHIS247
BARG311
BASP313

site_idAC8
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO B 604
ChainResidue
AHIS247
ASER248
ATHR251
BLYS400
BCYS401
BPHE414

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues14
DetailsBINDING:
ChainResidueDetails
AARG196
BHIS247
BARG311
BGLY353
BGLY384
BARG392
AASP219
AHIS247
AARG311
AGLY353
AGLY384
AARG392
BARG196
BASP219

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22223895
ChainResidueDetails
AMET1
BMET1

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455
ChainResidueDetails
ATYR188
BTYR188

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER472
BSER472

222415

PDB entries from 2024-07-10

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