6D5Y
Crystal structure of ERK2 G169D mutant
Summary for 6D5Y
Entry DOI | 10.2210/pdb6d5y/pdb |
Descriptor | Mitogen-activated protein kinase 1 (1 entity in total) |
Functional Keywords | transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 40533.63 |
Authors | Yin, J.,Jaiswal, B.S.,Wang, W. (deposition date: 2018-04-19, release date: 2019-02-27, Last modification date: 2024-03-13) |
Primary citation | Jaiswal, B.S.,Durinck, S.,Stawiski, E.W.,Yin, J.,Wang, W.,Lin, E.,Moffat, J.,Martin, S.E.,Modrusan, Z.,Seshagiri, S. ERK Mutations and Amplification Confer Resistance to ERK-Inhibitor Therapy. Clin. Cancer Res., 24:4044-4055, 2018 Cited by PubMed: 29760222DOI: 10.1158/1078-0432.CCR-17-3674 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.86 Å) |
Structure validation
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