6PC4
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![BU of 6pc4 by Molmil](/molmil-images/mine/6pc4) | Tubulin-RB3_SLD-TTL in complex with compound ABI-274 | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Kumar, G, Wang, Y, Li, W, White, S.W. | 登録日 | 2019-06-15 | 公開日 | 2020-04-22 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.602 Å) | 主引用文献 | Structure-Activity Relationship Study of Novel 6-Aryl-2-benzoyl-pyridines as Tubulin Polymerization Inhibitors with Potent Antiproliferative Properties. J.Med.Chem., 63, 2020
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3IB3
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![BU of 3ib3 by Molmil](/molmil-images/mine/3ib3) | Crystal Structure of SACOL2612 - CocE/NonD family hydrolase from Staphylococcus aureus | 分子名称: | CHLORIDE ION, CocE/NonD family hydrolase, NICKEL (II) ION, ... | 著者 | Domagalski, M.J, Chruszcz, M, Osinski, T, Skarina, T, Onopriyenko, O, Cymborowski, M, Shumilin, I.A, Savchenko, A, Edwards, A, Anderson, W, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2009-07-15 | 公開日 | 2009-08-11 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Crystal Structure of SACOL2612 - CocE/NonD family hydrolase from Staphylococcus aureus To be Published
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3J7V
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![BU of 3j7v by Molmil](/molmil-images/mine/3j7v) | Capsid Expansion Mechanism Of Bacteriophage T7 Revealed By Multi-State Atomic Models Derived From Cryo-EM Reconstructions | 分子名称: | Major capsid protein 10A | 著者 | Guo, F, Liu, Z, Fang, P.A, Zhang, Q, Wright, E.T, Wu, W, Zhang, C, Vago, F, Ren, Y, Jakata, J, Chiu, W, Serwer, P, Jiang, W. | 登録日 | 2014-08-12 | 公開日 | 2014-10-15 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | 主引用文献 | Capsid expansion mechanism of bacteriophage T7 revealed by multistate atomic models derived from cryo-EM reconstructions. Proc.Natl.Acad.Sci.USA, 111, 2014
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7BZ2
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![BU of 7bz2 by Molmil](/molmil-images/mine/7bz2) | Cryo-EM structure of the formoterol-bound beta2 adrenergic receptor-Gs protein complex. | 分子名称: | Beta2 adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhang, Y.N, Yang, F, Ling, S.L, Lv, P, Zhou, Y.X, Fang, W, Sun, W, Shi, P, Tian, C.L. | 登録日 | 2020-04-26 | 公開日 | 2020-08-05 | 実験手法 | ELECTRON MICROSCOPY (3.82 Å) | 主引用文献 | Single-particle cryo-EM structural studies of the beta2AR-Gs complex bound with a full agonist formoterol. Cell Discov, 6, 2020
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6N9T
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![BU of 6n9t by Molmil](/molmil-images/mine/6n9t) | Structure of a peptide-based photo-affinity cross-linker with Herceptin Fc | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin G1 FC, ... | 著者 | Sadowsky, J, Ultsch, M, Vance, N, Wang, W. | 登録日 | 2018-12-04 | 公開日 | 2019-01-16 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.576 Å) | 主引用文献 | Development, Optimization, and Structural Characterization of an Efficient Peptide-Based Photoaffinity Cross-Linking Reaction for Generation of Homogeneous Conjugates from Wild-Type Antibodies. Bioconjug. Chem., 30, 2019
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4X0R
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![BU of 4x0r by Molmil](/molmil-images/mine/4x0r) | Crystal structure of human MxB stalk domain | 分子名称: | Interferon-induced GTP-binding protein Mx2 | 著者 | Yu, X.-F, Xie, W. | 登録日 | 2014-11-23 | 公開日 | 2014-12-10 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.905 Å) | 主引用文献 | Structural insight into the assembly of human anti-HIV dynamin-like protein MxB/Mx2. Biochem.Biophys.Res.Commun., 456, 2015
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7BV2
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![BU of 7bv2 by Molmil](/molmil-images/mine/7bv2) | The nsp12-nsp7-nsp8 complex bound to the template-primer RNA and triphosphate form of Remdesivir(RTP) | 分子名称: | MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ... | 著者 | Yin, W, Mao, C, Luan, X, Shen, D, Shen, Q, Su, H, Wang, X, Zhou, F, Zhao, W, Gao, M, Chang, S, Xie, Y.C, Tian, G, Jiang, H.W, Tao, S.C, Shen, J, Jiang, Y, Jiang, H, Xu, Y, Zhang, S, Zhang, Y, Xu, H.E. | 登録日 | 2020-04-09 | 公開日 | 2020-04-22 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir. Science, 368, 2020
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7BV1
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![BU of 7bv1 by Molmil](/molmil-images/mine/7bv1) | Cryo-EM structure of the apo nsp12-nsp7-nsp8 complex | 分子名称: | Non-structural protein 7, Non-structural protein 8, RNA-directed RNA polymerase, ... | 著者 | Yin, W, Mao, C, Luan, X, Shen, D, Shen, Q, Su, H, Wang, X, Zhou, F, Zhao, W, Gao, M, Chang, S, Xie, Y.C, Tian, G, Jiang, H.W, Tao, S.C, Shen, J, Jiang, Y, Jiang, H, Xu, Y, Zhang, S, Zhang, Y, Xu, H.E. | 登録日 | 2020-04-09 | 公開日 | 2020-04-22 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir. Science, 368, 2020
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5CQ2
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![BU of 5cq2 by Molmil](/molmil-images/mine/5cq2) | Crystal Structure of tandem WW domains of ITCH in complex with TXNIP peptide | 分子名称: | E3 ubiquitin-protein ligase Itchy homolog, Thioredoxin-interacting protein, UNKNOWN ATOM OR ION | 著者 | Liu, Y, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2015-07-21 | 公開日 | 2015-09-16 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP. Biochem.J., 473, 2016
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5EJC
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![BU of 5ejc by Molmil](/molmil-images/mine/5ejc) | Crystal structural of the TSC1-TBC1D7 complex | 分子名称: | Hamartin, TBC1 domain family member 7 | 著者 | Wang, Z, Qin, J, Gong, W, Xu, W. | 登録日 | 2015-11-01 | 公開日 | 2016-03-02 | 最終更新日 | 2019-11-27 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structural Basis of the Interaction between Tuberous Sclerosis Complex 1 (TSC1) and Tre2-Bub2-Cdc16 Domain Family Member 7 (TBC1D7). J.Biol.Chem., 291, 2016
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2V14
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![BU of 2v14 by Molmil](/molmil-images/mine/2v14) | Kinesin 16B Phox-homology domain (KIF16B) | 分子名称: | KINESIN-LIKE MOTOR PROTEIN C20ORF23 | 著者 | Wilson, M.I, Williams, R.L, Cho, W, Hong, W, Blatner, N.R. | 登録日 | 2007-05-21 | 公開日 | 2007-07-31 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The Structural Basis of Novel Endosome Anchoring Activity of Kif16B Kinesin. Embo J., 26, 2007
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4X36
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![BU of 4x36 by Molmil](/molmil-images/mine/4x36) | Crystal structure of the autolysin LytA from Streptococcus pneumoniae TIGR4 | 分子名称: | Autolysin, CHOLINE ION, GLYCEROL, ... | 著者 | Cheng, W, Li, Q, Zhou, C.Z, Chen, Y.X. | 登録日 | 2014-11-28 | 公開日 | 2015-05-27 | 最終更新日 | 2015-06-24 | 実験手法 | X-RAY DIFFRACTION (2.101 Å) | 主引用文献 | Full-length structure of the major autolysin LytA. Acta Crystallogr.,Sect.D, 71, 2015
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6CUD
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![BU of 6cud by Molmil](/molmil-images/mine/6cud) | Structure of the human TRPC3 in a lipid-occupied, closed state | 分子名称: | (2R)-3-hydroxypropane-1,2-diyl dihexanoate, (2S)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(hexanoyloxy)propyl hexanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Lu, W, Du, J, Fan, C, Choi, W. | 登録日 | 2018-03-25 | 公開日 | 2018-05-16 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure of the human lipid-gated cation channel TRPC3. Elife, 7, 2018
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3D7W
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![BU of 3d7w by Molmil](/molmil-images/mine/3d7w) | Mistletoe Lectin I in Complex with Zeatin | 分子名称: | (2E)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol, (2Z)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Meyer, A, Rypniewski, W, Szymanski, M, Voelter, W, Barciszewski, J, Betzel, C. | 登録日 | 2008-05-22 | 公開日 | 2008-06-17 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | Structure of mistletoe lectin I from Viscum album in complex with the phytohormone zeatin Biochim.Biophys.Acta, 1784, 2008
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6NTS
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![BU of 6nts by Molmil](/molmil-images/mine/6nts) | Protein Phosphatase 2A (Aalpha-B56alpha-Calpha) holoenzyme in complex with a Small Molecule Activator of PP2A (SMAP) | 分子名称: | MANGANESE (II) ION, N-[(1R,2R,3S)-2-hydroxy-3-(10H-phenoxazin-10-yl)cyclohexyl]-4-(trifluoromethoxy)benzene-1-sulfonamide, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform, ... | 著者 | Huang, W, Taylor, D. | 登録日 | 2019-01-30 | 公開日 | 2020-05-06 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.63 Å) | 主引用文献 | Selective PP2A Enhancement through Biased Heterotrimer Stabilization. Cell, 181, 2020
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3AZJ
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![BU of 3azj by Molmil](/molmil-images/mine/3azj) | Crystal Structure of Human Nucleosome Core Particle Containing H4K44Q mutation | 分子名称: | 146-MER DNA, CHLORIDE ION, Histone H2A type 1-B/E, ... | 著者 | Iwasaki, W, Tachiwana, H, Kawaguchi, K, Shibata, T, Kagawa, W, Kurumizaka, H. | 登録日 | 2011-05-25 | 公開日 | 2011-09-21 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | 主引用文献 | Comprehensive Structural Analysis of Mutant Nucleosomes Containing Lysine to Glutamine (KQ) Substitutions in the H3 and H4 Histone-Fold Domains Biochemistry, 50, 2011
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3AZK
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![BU of 3azk by Molmil](/molmil-images/mine/3azk) | Crystal Structure of Human Nucleosome Core Particle Containing H4K59Q mutation | 分子名称: | 146-MER DNA, CHLORIDE ION, Histone H2A type 1-B/E, ... | 著者 | Iwasaki, W, Tachiwana, H, Kawaguchi, K, Shibata, T, Kagawa, W, Kurumizaka, H. | 登録日 | 2011-05-25 | 公開日 | 2011-09-21 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Comprehensive Structural Analysis of Mutant Nucleosomes Containing Lysine to Glutamine (KQ) Substitutions in the H3 and H4 Histone-Fold Domains Biochemistry, 50, 2011
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8Q79
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![BU of 8q79 by Molmil](/molmil-images/mine/8q79) | Structure of mBaoJin at pH 6.5 | 分子名称: | CHLORIDE ION, mBaoJin | 著者 | Samygina, V.R, Subach, O.M, Vlaskina, A.V, Nikolaeva, A.Y, Borshchevsky, V, Qin, W, Subach, F.V. | 登録日 | 2023-08-15 | 公開日 | 2023-12-27 | 最終更新日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Bright and stable monomeric green fluorescent protein derived from StayGold. Nat.Methods, 21, 2024
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3PTN
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![BU of 3ptn by Molmil](/molmil-images/mine/3ptn) | ON THE DISORDERED ACTIVATION DOMAIN IN TRYPSINOGEN. CHEMICAL LABELLING AND LOW-TEMPERATURE CRYSTALLOGRAPHY | 分子名称: | CALCIUM ION, TRYPSIN | 著者 | Walter, J, Steigemann, W, Singh, T.P, Bartunik, H, Bode, W, Huber, R. | 登録日 | 1981-10-26 | 公開日 | 1982-03-04 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | On the Disordered Activation Domain in Trypsinogen. Chemical Labelling and Low-Temperature Crystallography Acta Crystallogr.,Sect.B, 38, 1982
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1S5I
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![BU of 1s5i by Molmil](/molmil-images/mine/1s5i) | Fab (LNKB-2) of monoclonal antibody to Human Interleukin-2, crystal structure | 分子名称: | Fab-fragment of monoclonal antibody | 著者 | Pletnev, V.Z, Goryacheva, E.A, Tsygannik, I.N, Nesmeyanov, V.A, Pletnev, S.V, Pangborn, W, Duax, W. | 登録日 | 2004-01-21 | 公開日 | 2004-05-25 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | [A new crystal form of the Fab fragment of a monoclonal antibody to human interleukin-2: the three-dimensional structure at 2.7 A resolution]. Bioorg. Khim., 30
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6N47
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![BU of 6n47 by Molmil](/molmil-images/mine/6n47) | The structure of SB-2-204-tubulin complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-(2-chloropyrido[3,2-d]pyrimidin-4-yl)-7-methoxy-3,4-dihydroquinoxalin-2(1H)-one, CALCIUM ION, ... | 著者 | Arnst, K, Banerjee, S, Wang, Y, Li, W, Miller, D, Li, W. | 登録日 | 2018-11-17 | 公開日 | 2019-11-13 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | X-ray Crystal Structure Guided Discovery and Antitumor Efficacy of Dihydroquinoxalinone as Potent Tubulin Polymerization Inhibitors. Acs Chem.Biol., 14, 2019
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3HM8
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![BU of 3hm8 by Molmil](/molmil-images/mine/3hm8) | Crystal structure of the C-terminal Hexokinase domain of human HK3 | 分子名称: | 6-O-phosphono-beta-D-glucopyranose, Hexokinase-3, alpha-D-glucopyranose | 著者 | Nedyalkova, L, Tong, Y, Rabeh, W, Tempel, W, Landry, R, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | 登録日 | 2009-05-28 | 公開日 | 2009-08-11 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structure of the C-terminal Hexokinase domain of human HK3 To be Published
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5H0K
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![BU of 5h0k by Molmil](/molmil-images/mine/5h0k) | |
2ANK
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![BU of 2ank by Molmil](/molmil-images/mine/2ank) | orally active thrombin inhibitors in complex with thrombin and an exosite decapeptide | 分子名称: | N-[(1R)-2-[(1-{[({6-[AMINO(IMINO)METHYL]PYRIDIN-3-YL}METHYL)AMINO]CARBONYL}CYCLOPENTYL)AMINO]-1-(CYCLOHEXYLMETHYL)-2-OXOETHYL]GLYCINE, Thrombin heavy chain, Thrombin light chain, ... | 著者 | Lange, U.E.W, Baucke, D, Hornberger, W, Mack, H, Seitz, W, Hoeffken, H.W. | 登録日 | 2005-08-11 | 公開日 | 2006-11-14 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | 主引用文献 | Orally active thrombin inhibitors. Part 2: optimization of the P2-moiety BIOORG.MED.CHEM.LETT., 16, 2006
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5H0J
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![BU of 5h0j by Molmil](/molmil-images/mine/5h0j) | |