2ANK

orally active thrombin inhibitors in complex with thrombin and an exosite decapeptide

Summary for 2ANK

• Entry DOI: 10.2210/pdb2ank/pdb
• Related: 2A2X
• Related PRD ID: PRD_000480
• Descriptor: Thrombin heavy chain, Thrombin light chain, synthetic peptide, ... (5 entities in total)
• Functional Keywords: blood clotting, hydrolase, serine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted, extracellular space: P00734 P00734
• Total number of polymer chains: 3
• Total formula weight: 35615.66

Authors

Lange, U.E.W.,Baucke, D.,Hornberger, W.,Mack, H.,Seitz, W.,Hoeffken, H.W. (deposition date: 2005-08-11, release date: 2006-11-14, Last modification date: 2023-08-23)

• Primary citation: Lange, U.E.W.,Baucke, D.,Hornberger, W.,Mack, H.,Seitz, W.,Hoeffken, H.W.; Orally active thrombin inhibitors. Part 2: optimization of the P2-moiety; BIOORG.MED.CHEM.LETT., 16:2648-2653, 2006; PubMed: 16460939; DOI: 10.1016/j.bmcl.2006.01.046

Experimental method

X-RAY DIFFRACTION (2.46 Å)