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PDB: 12920 results

5L95
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Crystal structure of human UBA5 in complex with UFM1 and AMP
Descriptor: ADENOSINE MONOPHOSPHATE, Ubiquitin-fold modifier 1, Ubiquitin-like modifier-activating enzyme 5, ...
Authors:Oweis, W, Padala, P, Wiener, R.
Deposit date:2016-06-09
Release date:2016-09-21
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Trans-Binding Mechanism of Ubiquitin-like Protein Activation Revealed by a UBA5-UFM1 Complex.
Cell Rep, 16, 2016
8PK4
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Cryo EM structure of the type 5A polymorph of alpha-synuclein.
Descriptor: Alpha-synuclein
Authors:Frey, L, Qureshi, B.M, Kwiatkowski, W, Rhyner, D, Greenwald, J, Riek, R.
Deposit date:2023-06-24
Release date:2024-05-29
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:On the pH-dependence of alpha-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation
Elife, 2023
5AY9
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Crystal structure of Ruminococcus albus 4-O-beta-D-mannosyl-D-glucose phosphorylase (RaMP1)
Descriptor: 4-O-beta-D-mannosyl-D-glucose phosphorylase
Authors:Ye, Y, Saburi, W, Kato, K, Yao, M.
Deposit date:2015-08-11
Release date:2016-03-23
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural insights into the difference in substrate recognition of two mannoside phosphorylases from two GH130 subfamilies
Febs Lett., 590, 2016
1OIH
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Crystal structure of the alkylsulfatase AtsK, a non-heme Fe(II) alphaketoglutarate dependent Dioxygenase
Descriptor: PUTATIVE ALKYLSULFATASE ATSK, SODIUM ION
Authors:Mueller, I, Kahnert, A, Pape, T, Dierks, T, Meyer-Klauke, W, Kertesz, M, Uson, I.
Deposit date:2003-06-18
Release date:2004-03-30
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Crystal Structure of the Alkylsulfatase Atsk: Insights Into the Catalytic Mechanism of the Fe(II) -Ketoglutarate-Dependent Dioxygenase Superfamily
Biochemistry, 42, 2004
8PK2
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Cryo EM structure of the type 1m polymorph of alpha-synuclein
Descriptor: Alpha-synuclein
Authors:Frey, L, Qureshi, B.M, Kwiatkowski, W, Rhyner, D, Greenwald, J, Riek, R.
Deposit date:2023-06-24
Release date:2024-05-29
Method:ELECTRON MICROSCOPY (3.26 Å)
Cite:On the pH-dependence of alpha-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation
Elife, 2023
5BJP
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Crystal structure of the Corn RNA aptamer in complex with DFHO, iridium hexammine soak
Descriptor: (5Z)-5-[(3,5-difluoro-4-hydroxyphenyl)methylidene]-2-[(E)-(hydroxyimino)methyl]-3-methyl-3,5-dihydro-4H-imidazol-4-one, DIMETHYL SULFOXIDE, IRIDIUM ION, ...
Authors:Warner, K.D, Song, W, Filonov, G.S, Jaffrey, S.R, Ferre-D'Amare, A.R.
Deposit date:2016-08-21
Release date:2017-09-27
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:A homodimer interface without base pairs in an RNA mimic of red fluorescent protein.
Nat. Chem. Biol., 13, 2017
2YGQ
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BU of 2ygq by Molmil
WIF domain-epidermal growth factor (EGF)-like domains 1-3 of human Wnt inhibitory factor 1 in complex with 1,2- dipalmitoylphosphatidylcholine
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Malinauskas, T, Aricescu, A.R, Lu, W, Siebold, C, Jones, E.Y.
Deposit date:2011-04-19
Release date:2011-07-13
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.951 Å)
Cite:Modular Mechanism of Wnt Signaling Inhibition by Wnt Inhibitory Factor 1
Nat.Struct.Mol.Biol., 18, 2011
2YQZ
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BU of 2yqz by Molmil
Crystal Structure of Hypothetical Methyltransferase TTHA0223 from Thermus thermophilus HB8 complexed with S-adenosylmethionine
Descriptor: Hypothetical protein TTHA0223, S-ADENOSYLMETHIONINE
Authors:Kagawa, W, Kurumizaka, H, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-04-01
Release date:2007-10-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of Hypothetical Methyltransferase TTHA0223 from Thermus thermophilus HB8 complexed with S-adenosylmethionine
To be published
6JL7
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BU of 6jl7 by Molmil
crystal structure of TBC1D23 N terminal domain
Descriptor: TBC1 domain family member 23
Authors:Sun, Q, Hu, W, Jia, D.
Deposit date:2019-03-04
Release date:2020-03-04
Last modified:2021-09-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of TBC1D23 N-terminus reveals a novel role for rhodanese domain.
Plos Biol., 18, 2020
5KZ5
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BU of 5kz5 by Molmil
Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery: the Complex Formed by the Iron Donor, the Sulfur Donor, and the Scaffold
Descriptor: Cysteine desulfurase, mitochondrial, Frataxin, ...
Authors:Gakh, O, Ranatunga, W, Smith, D.Y, Ahlgren, E.C, Al-Karadaghi, S, Thompson, J.R, Isaya, G.
Deposit date:2016-07-22
Release date:2016-08-31
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (14.3 Å)
Cite:Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery.
J.Biol.Chem., 291, 2016
2YJJ
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Structure of Dps from MICROBACTERIUM ARBORESCENS in the low iron form
Descriptor: AFP, FE (III) ION, Iron(II) oxide
Authors:Zeth, K, Buecheler, R, Boland, W.
Deposit date:2011-05-19
Release date:2011-06-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure and Mechanism of Iron Translocation by a Dps Protein from Microbacterium Arborescens.
J.Biol.Chem., 286, 2011
2YFX
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BU of 2yfx by Molmil
Structure of L1196M Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib
Descriptor: 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine, TYROSINE-PROTEIN KINASE RECEPTOR
Authors:McTigue, M, Deng, Y, Liu, W, Brooun, A.
Deposit date:2011-04-08
Release date:2011-05-04
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Design of Potent and Selective Inhibitors to Overcome Clinical Anaplastic Lymphoma Kinase Mutations Resistant to Crizotinib.
J.Med.Chem., 57, 2014
1JIV
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BU of 1jiv by Molmil
T4 phage BGT in complex with Mg2+ : Form II
Descriptor: DNA BETA-GLUCOSYLTRANSFERASE, MAGNESIUM ION, URIDINE-5'-DIPHOSPHATE
Authors:Morera, S, Lariviere, L, Kurzeck, J, Aschke-Sonnenborn, U, Freemont, P.S, Janin, J, Ruger, W.
Deposit date:2001-07-03
Release date:2001-08-15
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:High resolution crystal structures of T4 phage beta-glucosyltransferase: induced fit and effect of substrate and metal binding.
J.Mol.Biol., 311, 2001
1JJ9
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BU of 1jj9 by Molmil
Crystal Structure of MMP8-Barbiturate Complex Reveals Mechanism for Collagen Substrate Recognition
Descriptor: 2-HYDROXY-5-[4-(2-HYDROXY-ETHYL)-PIPERIDIN-1-YL]-5-PHENYL-1H-PYRIMIDINE-4,6-DIONE, CALCIUM ION, Matrix Metalloproteinase 8, ...
Authors:Brandstetter, H, Grams, F, Glitz, D, Lang, A, Huber, R, Bode, W, Krell, H.-W, Engh, R.A.
Deposit date:2001-07-04
Release date:2001-08-01
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The 1.8-A crystal structure of a matrix metalloproteinase 8-barbiturate inhibitor complex reveals a previously unobserved mechanism for collagenase substrate recognition.
J.Biol.Chem., 276, 2001
2YIZ
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BU of 2yiz by Molmil
X-ray structure of Mycobacterium tuberculosis Dodecin
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, COENZYME A, ...
Authors:Vinzenz, X, Grosse, W, Linne, U, Meissner, B, Essen, L.-O.
Deposit date:2011-05-17
Release date:2011-10-12
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Chemical Engineering of Mycobacterium Tuberculosis Dodecin Hybrids.
Chem.Commun.(Camb.), 47, 2011
2YD9
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BU of 2yd9 by Molmil
Crystal structure of the N-terminal Ig1-3 module of Human Receptor Protein Tyrosine Phosphatase Sigma
Descriptor: 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
Authors:Coles, C.H, Shen, Y, Tenney, A.P, Siebold, C, Sutton, G.C, Lu, W, Gallagher, J.T, Jones, E.Y, Flanagan, J.G, Aricescu, A.R.
Deposit date:2011-03-18
Release date:2011-04-13
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Proteoglycan-Specific Molecular Switch for Rptp Sigma Clustering and Neuronal Extension.
Science, 332, 2011
2YJK
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BU of 2yjk by Molmil
Structure of Dps from MICROBACTERIUM ARBORESCENS in the high iron form
Descriptor: AFP, FE (III) ION, Iron(II) oxide
Authors:Zeth, K, Buecheler, R, Boland, W.
Deposit date:2011-05-19
Release date:2011-06-01
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure and Mechanism of Iron Translocation by a Dps Protein from Microbacterium Arborescens.
J.Biol.Chem., 286, 2011
2YQU
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BU of 2yqu by Molmil
Crystal structures and evolutionary relationship of two different lipoamide dehydrogenase(E3s) from Thermus thermophilus
Descriptor: 2-oxoglutarate dehydrogenase E3 component, CARBONATE ION, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Kondo, H, Hossain, M.T, Adachi, W, Nakai, T, Kamiya, N, Kuramitsu, K.
Deposit date:2007-03-31
Release date:2008-04-01
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structures and evolutionary relationship of two different lipoamide dehydrogenase(E3s) from Thermus thermophilus
To be Published
2L6T
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BU of 2l6t by Molmil
Efficacy of an HIV-1 entry inhibitor targeting the GP41 fusion peptide
Descriptor: VIR-576
Authors:Forssmann, W, The, Y, Stoll, M, Adermann, K, Albrecht, U, Barlos, K, Busmann, A, Can les-Mayordomo, A, Gimenez-Gallego, G, Hirsch, J, Jimenez-Barbero, J, Meyer-Olson, D, Muench, J, Perez-Castells, J, Staendker, L, Kirchhoff, F, Schmidt, R.E.
Deposit date:2010-11-24
Release date:2011-01-19
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Short-term monotherapy in HIV-infected patients with a virus entry inhibitor against the gp41 fusion peptide.
Sci Transl Med, 2, 2010
2YJ8
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BU of 2yj8 by Molmil
CATHEPSIN L WITH A NITRILE INHIBITOR
Descriptor: (2S,4R)-4-(2-chlorophenyl)sulfonyl-N-[1-(iminomethyl)cyclopropyl]-1-[1-(4-iodophenyl)cyclopropyl]carbonyl-pyrrolidine-2-carboxamide, CATHEPSIN L1, GLYCEROL
Authors:Banner, D.W, Benz, J.M, Haap, W.
Deposit date:2011-05-19
Release date:2011-11-23
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Halogen Bonding at the Active Sites of Human Cathepsin L and Mek1 Kinase: Efficient Interactions in Different Environments.
Chemmedchem, 6, 2011
2YRK
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BU of 2yrk by Molmil
Solution structure of the zf-C2H2 domain in zinc finger homeodomain 4
Descriptor: ZINC ION, Zinc finger homeobox protein 4
Authors:Tanabe, W, Suzuki, S, Muto, Y, Inoue, M, Kigawa, T, Shirouzu, M, Tarada, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-04-02
Release date:2007-10-02
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Solution structure of the zf-C2H2 domain in zinc finger homeodomain 4
To be Published
1P6I
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BU of 1p6i by Molmil
Rat neuronal NOS heme domain with (4S)-N-(4-amino-5-[aminoethyl]aminopentyl)-N'-nitroguanidine bound
Descriptor: 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, N-{(4S)-4-AMINO-5-[(2-AMINOETHYL)AMINO]PENTYL}-N'-NITROGUANIDINE, ...
Authors:Flinspach, M.L, Li, H, Jamal, J, Yang, W, Huang, H, Hah, J.-M, Gomez-Vidal, J.A, Litzinger, E.A, Silverman, R.B, Poulos, T.L.
Deposit date:2003-04-29
Release date:2004-01-13
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase.
Nat.Struct.Mol.Biol., 11, 2004
2YGP
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BU of 2ygp by Molmil
WIF domain-EGF-like domain 1 Met77Trp of human Wnt inhibitory factor 1 in complex with 1,2-dipalmitoylphosphatidylcholine
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Malinauskas, T, Aricescu, A.R, Lu, W, Siebold, C, Jones, E.Y.
Deposit date:2011-04-19
Release date:2011-07-13
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.222 Å)
Cite:Modular Mechanism of Wnt Signaling Inhibition by Wnt Inhibitory Factor 1
Nat.Struct.Mol.Biol., 18, 2011
8QF8
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BU of 8qf8 by Molmil
GH146 beta-L-arabinofuranosidase from Bacteroides thetaioatomicron in complex with beta-l-arabinofurano cyclophellitol aziridine
Descriptor: (1~{S},2~{S},3~{S},4~{R})-4-azanyl-3-(hydroxymethyl)cyclopentane-1,2-diol, (1~{S},2~{S},3~{S},4~{S},5~{S})-4-(hydroxymethyl)-6-azabicyclo[3.1.0]hexane-2,3-diol, Glycosyl hydrolase, ...
Authors:Borlandelli, V, Offen, W, Moroz, O.V, Nin-Hill, A, McGregor, N, Binkhorst, L, Armstrong, Z, Ishiwata, A, Artola, M, Rovira, C, Davies, G.J, Overkleeft, H.
Deposit date:2023-09-04
Release date:2023-12-13
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:beta-l- Arabino furano-cyclitol Aziridines Are Covalent Broad-Spectrum Inhibitors and Activity-Based Probes for Retaining beta-l-Arabinofuranosidases.
Acs Chem.Biol., 18, 2023
2YII
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BU of 2yii by Molmil
Manipulating the regioselectivity of phenylalanine aminomutase: new insights into the reaction mechanism of MIO-dependent enzymes from structure-guided directed evolution
Descriptor: BETA-MERCAPTOETHANOL, FORMIC ACID, GLYCEROL, ...
Authors:Wu, B, Szymanski, W, Wybenga, G.G, Heberling, M.M, Bartsch, S, Wildeman, S, Poelarends, G.J, Feringa, B.L, Dijkstra, B.W, Janssen, D.B.
Deposit date:2011-05-13
Release date:2011-11-09
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Mechanism-Inspired Engineering of Phenylalanine Aminomutase for Enhanced Beta-Regioselective Asymmetric Amination of Cinnamates.
Angew.Chem.Int.Ed.Engl., 51, 2012

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