2L6T

Efficacy of an HIV-1 entry inhibitor targeting the GP41 fusion peptide

Summary for 2L6T

• Entry DOI: 10.2210/pdb2l6t/pdb
• Related: 2JNR 2L6S
• Descriptor: VIR-576 (1 entity in total)
• Functional Keywords: anti-viral polypeptide, gp41 fusion peptide, fp1-24, antiviral protein
• Total number of polymer chains: 1
• Total formula weight: 2252.69

Authors

Forssmann, W.,The, Y.,Stoll, M.,Adermann, K.,Albrecht, U.,Barlos, K.,Busmann, A.,Can les-Mayordomo, A.,Gimenez-Gallego, G.,Hirsch, J.,Jimenez-Barbero, J.,Meyer-Olson, D.,Muench, J.,Perez-Castells, J.,Staendker, L.,Kirchhoff, F.,Schmidt, R.E. (deposition date: 2010-11-24, release date: 2011-01-19, Last modification date: 2011-07-13)

• Primary citation: Forssmann, W.G.,The, Y.H.,Stoll, M.,Adermann, K.,Albrecht, U.,Barlos, K.,Busmann, A.,Canales-Mayordomo, A.,Gimenez-Gallego, G.,Hirsch, J.,Jimenez-Barbero, J.,Meyer-Olson, D.,Munch, J.,Perez-Castells, J.,Standker, L.,Kirchhoff, F.,Schmidt, R.E.; Short-term monotherapy in HIV-infected patients with a virus entry inhibitor against the gp41 fusion peptide.; Sci Transl Med, 2:63re3-63re3, 2010; PubMed: 21178138; DOI: 10.1126/scitranslmed.3001697

Experimental method

SOLUTION NMR