2YJ8

CATHEPSIN L WITH A NITRILE INHIBITOR

Summary for 2YJ8

• Entry DOI: 10.2210/pdb2yj8/pdb
• Related: 1CJL 1CS8 1ICF 1MHW 2VHS 2XU1 2XU3 2XU4 2XU5 2YJ2 2YJ9 2YJB 2YJC
• Descriptor: CATHEPSIN L1, (2S,4R)-4-(2-chlorophenyl)sulfonyl-N-[1-(iminomethyl)cyclopropyl]-1-[1-(4-iodophenyl)cyclopropyl]carbonyl-pyrrolidine-2-carboxamide, GLYCEROL, ... (4 entities in total)
• Functional Keywords: hydrolase, drug design, thiol protease
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Lysosome: P07711
• Total number of polymer chains: 1
• Total formula weight: 24909.70

Authors

Banner, D.W.,Benz, J.M.,Haap, W. (deposition date: 2011-05-19, release date: 2011-11-23)

• Primary citation: Hardegger, L.A.,Kuhn, B.,Spinnler, B.,Anselm, L.,Ecabert, R.,Stihle, M.,Gsell, B.,Thoma, R.,Diez, J.,Benz, J.M.,Plancher, J.,Hartmann, G.,Isshiki, Y.,Morikami, K.,Shimma, N.,Haap, W.,Banner, D.W.,Diederich, F.; Halogen Bonding at the Active Sites of Human Cathepsin L and Mek1 Kinase: Efficient Interactions in Different Environments.; Chemmedchem, 6:2048-, 2011; PubMed: 21898833; DOI: 10.1002/CMDC.201100353

Experimental method

X-RAY DIFFRACTION (1.3 Å)