2YJC

CATHEPSIN L WITH A NITRILE INHIBITOR

Summary for 2YJC

Entry DOI	10.2210/pdb2yjc/pdb
Related	1CJL 1CS8 1ICF 1MHW 2VHS 2XU1 2XU3 2XU4 2XU5 2YJ2 2YJ8 2YJB
Descriptor	CATHEPSIN L1, (2S,4R)-1-[1-(4-chlorophenyl)cyclopropyl]carbonyl-4-(2-chlorophenyl)sulfonyl-N-[1-(iminomethyl)cyclopropyl]pyrrolidine-2-carboxamide (3 entities in total)
Functional Keywords	hydrolase, inhibitor, drug design, thiol protease
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Lysosome: P07711
Total number of polymer chains	1
Total formula weight	24726.16
Authors	Banner, D.W.,Benz, J.M.,Haap, W. (deposition date: 2011-05-19, release date: 2011-11-23, Last modification date: 2011-11-30)
Primary citation	Hardegger, L.A.,Kuhn, B.,Spinnler, B.,Anselm, L.,Ecabert, R.,Stihle, M.,Gsell, B.,Thoma, R.,Diez, J.,Benz, J.M.,Plancher, J.,Hartmann, G.,Isshiki, Y.,Morikami, K.,Shimma, N.,Haap, W.,Banner, D.W.,Diederich, F. Halogen Bonding at the Active Sites of Human Cathepsin L and Mek1 Kinase: Efficient Interactions in Different Environments. Chemmedchem, 6:2048-, 2011 Cited by PubMed: 21898833 DOI: 10.1002/CMDC.201100353 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.14 Å)

Structure validation