2YJ2
CATHEPSIN L WITH A NITRILE INHIBITOR
Summary for 2YJ2
Entry DOI | 10.2210/pdb2yj2/pdb |
Related | 1CJL 1CS8 1ICF 1MHW 2VHS 2XU1 2XU3 2XU4 2XU5 2YJ8 2YJ9 2YJB 2YJC |
Descriptor | CATHEPSIN L1, (2S,4R)-1-[1-(4-BROMOPHENYL)CYCLOPROPYL]CARBONYL-4-(2-CHLOROPHENYL)SULFONYL-N-[1-(IMINOMETHYL)CYCLOPROPYL]PYRROLIDINE-2-CARBOXAMIDE, GLYCEROL, ... (4 entities in total) |
Functional Keywords | hydrolase, drug design, thiol protease |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Lysosome: P07711 |
Total number of polymer chains | 1 |
Total formula weight | 24862.70 |
Authors | Banner, D.W.,Benz, J.M.,Haap, W. (deposition date: 2011-05-18, release date: 2011-11-23, Last modification date: 2023-12-20) |
Primary citation | Hardegger, L.A.,Kuhn, B.,Spinnler, B.,Anselm, L.,Ecabert, R.,Stihle, M.,Gsell, B.,Thoma, R.,Diez, J.,Benz, J.M.,Plancher, J.,Hartmann, G.,Isshiki, Y.,Morikami, K.,Shimma, N.,Haap, W.,Banner, D.W.,Diederich, F. Halogen Bonding at the Active Sites of Human Cathepsin L and Mek1 Kinase: Efficient Interactions in Different Environments. Chemmedchem, 6:2048-, 2011 Cited by PubMed: 21898833DOI: 10.1002/CMDC.201100353 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.15 Å) |
Structure validation
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