2YII
Manipulating the regioselectivity of phenylalanine aminomutase: new insights into the reaction mechanism of MIO-dependent enzymes from structure-guided directed evolution
Summary for 2YII
Entry DOI | 10.2210/pdb2yii/pdb |
Descriptor | PHENYLALANINE AMMONIA-LYASE, BETA-MERCAPTOETHANOL, FORMIC ACID, ... (5 entities in total) |
Functional Keywords | lyase |
Biological source | TAXUS WALLICHIANA VAR. CHINENSIS (CHINESE YEW) |
Total number of polymer chains | 4 |
Total formula weight | 311115.79 |
Authors | Wu, B.,Szymanski, W.,Wybenga, G.G.,Heberling, M.M.,Bartsch, S.,Wildeman, S.,Poelarends, G.J.,Feringa, B.L.,Dijkstra, B.W.,Janssen, D.B. (deposition date: 2011-05-13, release date: 2011-11-09, Last modification date: 2023-12-20) |
Primary citation | Wu, B.,Szymanski, W.,Wybenga, G.G.,Heberling, M.M.,Bartsch, S.,De Wildeman, S.,Poelarends, G.J.,Feringa, B.L.,Dijkstra, B.W.,Janssen, D.B. Mechanism-Inspired Engineering of Phenylalanine Aminomutase for Enhanced Beta-Regioselective Asymmetric Amination of Cinnamates. Angew.Chem.Int.Ed.Engl., 51:482-, 2012 Cited by PubMed: 22113970DOI: 10.1002/ANIE.201106372 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.18 Å) |
Structure validation
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