2YII

Manipulating the regioselectivity of phenylalanine aminomutase: new insights into the reaction mechanism of MIO-dependent enzymes from structure-guided directed evolution

Summary for 2YII

Entry DOI	10.2210/pdb2yii/pdb
Descriptor	PHENYLALANINE AMMONIA-LYASE, BETA-MERCAPTOETHANOL, FORMIC ACID, ... (5 entities in total)
Functional Keywords	lyase
Biological source	TAXUS WALLICHIANA VAR. CHINENSIS (CHINESE YEW)
Total number of polymer chains	4
Total formula weight	311115.79
Authors	Wu, B.,Szymanski, W.,Wybenga, G.G.,Heberling, M.M.,Bartsch, S.,Wildeman, S.,Poelarends, G.J.,Feringa, B.L.,Dijkstra, B.W.,Janssen, D.B. (deposition date: 2011-05-13, release date: 2011-11-09, Last modification date: 2023-12-20)
Primary citation	Wu, B.,Szymanski, W.,Wybenga, G.G.,Heberling, M.M.,Bartsch, S.,De Wildeman, S.,Poelarends, G.J.,Feringa, B.L.,Dijkstra, B.W.,Janssen, D.B. Mechanism-Inspired Engineering of Phenylalanine Aminomutase for Enhanced Beta-Regioselective Asymmetric Amination of Cinnamates. Angew.Chem.Int.Ed.Engl., 51:482-, 2012 Cited by PubMed: 22113970 DOI: 10.1002/ANIE.201106372 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.18 Å)

Structure validation